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Investigational use with small case series suggesting frequency reduction in chronic tension headache via reduction of pericranial muscle tension and venous congestion.

Investigational use for symptomatic relief of grade II-III internal/external hemorrhoidal disease; does not address anatomic prolapse.

Investigational adjunctive use in primary open-angle glaucoma; weak case-series evidence. Not a substitute for IOP-lowering eye drops or surgery.

Investigational use for dry eye disease; mechanism via reduction of meibomian gland inflammation. Weak case-series evidence.

Investigational adjunctive use; one small pilot suggests transient improvement in tender-point and quality-of-life scores. Not a primary treatment.

Investigational use for chronic lipodermatosclerosis; small case series suggest softening of fibrotic gaiter-area skin changes.

Investigational use for androgenic alopecia; mechanism via local scalp perfusion improvement. Single-arm series only.

Investigational use for erythematotelangiectatic rosacea; case-series evidence for reduction in facial erythema.

Investigational use for localized stable plaque psoriasis; small case series suggest plaque thinning. Not a primary treatment.

Investigational use for localized refractory atopic dermatitis; very limited case-series evidence.

Investigational use for chronic recurrent (non-acute) cellulitis with underlying lymphedema or venous insufficiency.

Investigational adjunctive use; case-series evidence for limb-volume reduction when combined with complete decongestive therapy.

Investigational use for acute monoarticular gout when NSAIDs and colchicine are contraindicated; small case series.

Investigational use for chronic mid-substance Achilles tendinopathy; case-series evidence for pain and VISA-A score improvement.

Investigational use for non-surgical rotator cuff tendinopathy and chronic shoulder impingement; case-series evidence for pain reduction.

Investigational use for stenosing tenosynovitis of the digital flexor pulleys; small case series.

Investigational use for early-stage Dupuytren's nodules; case-series evidence for nodule softening, not for established contracture.

Investigational use for plantar fascia nodules in early Ledderhose disease; case-series evidence for symptomatic improvement.

Investigational use for category III CP/CPPS; small case series suggest symptom reduction. Multimodal therapy remains standard.

Investigational adjunctive use for chronic endometriosis-related pelvic pain; very limited evidence. Not a substitute for hormonal or surgical management.

Investigational use for primary dysmenorrhea refractory to NSAIDs and hormonal contraception; small case series.

Investigational use for non-specific chronic pelvic pain syndrome; case-series evidence for symptom reduction within multimodal management.

Investigational use for chronic subjective tinnitus; case-series evidence for THI score improvement. Mechanism speculative.

Investigational use for residual symptoms in the post-acute phase of DVT (>6 weeks); contraindicated in acute DVT.

Investigational adjunctive use for Hurley stage I-II hidradenitis suppurativa in quiescent phase between flares.

Investigational use for pulsatile vascular-origin tinnitus distinct from subjective tinnitus; case-report evidence only.

Investigational adjunct for vestibular attack frequency reduction in definite Meniere's disease per AAO-HNS 2015 criteria; case-series evidence.

Investigational adjunct in acute idiopathic facial nerve palsy; case-series suggest faster House-Brackmann recovery as add-on to corticosteroids.

Investigational use for classical trigeminal neuralgia refractory to first-line carbamazepine; anecdotal pain-frequency reduction.

Investigational use for lumbosacral radicular pain without disc herniation (foraminal stenosis, facet hypertrophy, lateral recess); case-series evidence.

Investigational adjunct in stage II frozen shoulder; small case series suggest accelerated range-of-motion recovery as add-on to physiotherapy.

Investigational use for insertional Achilles tendinopathy distinct from mid-substance disease; weaker case-series response.

Investigational use for stenosing tenosynovitis of the first dorsal extensor compartment; small case series.

Investigational use for trigger finger recurrent after corticosteroid injection failure; pre-surgical alternative explored in case series.

Investigational use for symptomatic plantar calcaneal spur; distinguished from plantar fasciitis by radiographic spur with localized pain.

Investigational use for chronic subacromial bursitis distinct from acute infectious bursitis; case-series evidence for pain reduction.

Investigational use for chronic greater trochanteric pain syndrome including bursitis and gluteal tendinopathy; case-series evidence.

Investigational use for chronic costochondritis with persistent chest wall pain after cardiac causes excluded; small case series.

Investigational use for SI joint mechanical pain with positive provocation tests; case-series evidence for pain reduction.

Investigational use for chronic coccyx pain after fall, childbirth, or idiopathic onset; small case series for refractory cases.

Investigational use for isolated piriformis syndrome with positive FAIR test and excluded lumbar pathology; case-series evidence.

Investigational adjunct for chronic migraine (≥15 days/month, ≥8 migrainous) refractory to two preventive classes; distinct from episodic migraine.

Investigational adjunct for chronic tension-type headache (≥15 days/month) with persistent pericranial muscle tenderness; small case series.

Investigational adjunct for cervicogenic headache referred from upper cervical (C1-C3) joints; case-series evidence for pain reduction.

Investigational adjunct for adult recalcitrant atopic dermatitis (EASI >21) refractory to dupilumab or JAK inhibitor; very preliminary data.

Investigational adjunct for chronic plaque psoriasis recalcitrant to biologic therapy; very preliminary case-series evidence.

Investigational adjunct for papulopustular rosacea subtype with persistent inflammatory lesions; small case series.

Investigational adjunct for Hurley stage I localized hidradenitis suppurativa; distinct from Hurley II-III with extensive disease.

Investigational adjunct for keloid scars refractory to intralesional corticosteroid; case series suggest volume reduction as adjunctive therapy.

Investigational adjunct for hypertrophic scars (within original wound boundary) distinct from keloid; case-series evidence for volume reduction.