Умная библиотека
Фасетный поиск по всем 5 реестрам. Фильтр по типу реестра, уровню доказательности или области безопасности.
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Compounds
20Ghilanten
Factor Xa inhibitor with anti-metastatic activity in animal cancer models — translational dual-use compound.
Granulin (leech-derived)
Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
Sylvestin
43-amino-acid contact-kinin pathway inhibitor from forest leech Haemadipsa sylvestris — plasma kallikrein + FXIIa dual blocker; preclinical stroke neuroprotection without bleeding tendency.
RK22
Novel antimicrobial peptide from Hirudinaria manillensis salivary transcriptome — MIC 6.25 µg/mL against MRSA, no thrombogenic effect, in vivo efficacy in mice.
WP-PEP (LRELEDALEQER)
Thrombin exosite-II-binding 12-residue anticoagulant peptide screened from Whitmania pigra hydrolysates (Hua 2025) via computation-guided strategy.
WP Peptide LR
Whitmania pigra-derived anticoagulant peptide showing neuroprotection in rat MCAO ischemia-reperfusion model (Liu 2026) — thrombin modulation + fibrinolysis homeostasis.
Poeciguamerin
Antistasin-domain dual analgesic + antithrombotic serine protease inhibitor from Poecilobdella manillensis — Wang 2023 explains the painless-bleed phenotype.
Poecistasin
48-aa antistasin-type single-domain serine protease inhibitor from Poecilobdella manillensis — anticoagulant + anti-ischemic-stroke preclinical activity (Tang 2018).
Pigrin
Selective PAR1 antagonist from non-hematophagous Whitmania pigra — Ren 2019 demonstrates antithrombotic activity in rat without prolonging bleeding time.
WP-77
20.8 kDa thermostable anticoagulant protein from Whitmania pigra decoction — active across 20-100°C and pH 2-8 (Zhang 2022).
WP-30
30-residue antiplatelet peptide from Whitmania pigra selectively inhibiting thrombin-induced platelet aggregation — Liu 2016 demonstrates rat arterio-venous shunt thrombosis attenuation.
HnSaratin
Hirudo nipponia saratin homolog — Cheng 2023 cloning + recombinant production demonstrates collagen-binding antiplatelet activity.
Hirudin Anti-Pulmonary-Fibrosis (PGC1α / Sirt3)
Preclinical demonstration that hirudin attenuates idiopathic-pulmonary-fibrosis fibroblast senescence via the PGC1α / Sirt3 axis — He 2024 mouse model + primary lung fibroblasts.
Leech Extract >10 kDa Anti-Pulmonary-Fibrosis (TGFβ1 / Smad3)
Molecular-weight-fractionated leech extract (>10 kDa) attenuates pulmonary fibrosis via TGFβ1 / Smad3 / PKM2 / Smad7 — Zhang 2024 bleomycin-induced mouse model.
Shuxuetong (SXT) Injection Active Peptides
Three angiogenic peptides (DSYVGDEAQSKR, YNELRVAPEEHP, IQFLPEGSPVTM) from a leech + earthworm Shuxuetong (SXT) injection — Sun 2022 hindlimb-ischemia model.
Leech / LSE Flap-Survival VEGF Induction (Rat)
Dorsal random skin-flap rat model: medicinal leech application + leech saliva extract injection both increase VEGF, neovascularisation + reduce necrosis vs control — Ünal 2025.
WP-PEP-LRELEDALEQER
Computation-guided 12-mer anticoagulant peptide from Whitmania pigra hydrolysate targeting thrombin Exosite II — Hua 2025 in vivo + SPR validation.
WP-77 Thermostable Anticoagulant (Whitmania pigra)
Thermostable (20–100 °C, pH 2–8) ~20.8 kDa anticoagulant protein from Whitmania pigra decoction — Zhang 2022 in vivo carrageenan thrombosis model.
Leech Saliva Pulmonary-Fibrosis Pharmacology (Composite)
Review of leech extract + saliva pharmacological mechanisms relevant to pulmonary fibrosis and other fibrotic diseases — Sarli 2019 (Iranian Group).
RK22 Antimicrobial Peptide (MRSA-Active)
11-mer antimicrobial peptide RK22 from Hirudinaria manillensis salivary-gland transcriptome — Lu 2023 demonstrates MRSA killing + biofilm eradication.