WP-77
20.8 kDa thermostable anticoagulant protein from Whitmania pigra decoction — active across 20-100°C and pH 2-8 (Zhang 2022).
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- 20.8 kDa thermostable anticoagulant protein from Whitmania pigra decoction — active across 20-100°C and pH 2-8 (Zhang 2022).
- Evidence level
- Preclinical (animal)
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
WP-77's preclinical thermostable anticoagulant activity does NOT establish clinical efficacy. No FDA-approved derivative exists; W. pigra is a non-hematophagous TCM leech, not the FDA-cleared K040187 medicinal leech (H. medicinalis / H. verbana).
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Molecular weight
- 20,800 Da
- Source species
- Whitmania pigra
- Discovered
- 2022 · Zhang Y et al.
Biological Targets
- → aPTT-prolonging mechanism (intrinsic pathway emphasis)
- → thrombin time prolongation
Key Citations
- Zhang Y et al. (2022), J Ethnopharmacol · PMID 35032585
External Resources
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