Библиотека исследований
Курируемые обзоры рецензируемых исследований, имеющих отношение к гирудотерапии
ASH structured research registries
In addition to 10059+ long-form research articles below, ASH curates 5 structured registries with cross-linking:
Editorial transparency & research roadmap
ASH treats this library as a living dataset. Current import baseline: 10059 long-form articles plus 449 metadata-imported PubMed/DOI records, with a public 10,000-article ingestion target. The pages below explain how we grade evidence, what PMIDs are still unverified, and where the corpus is going next.
Последнее обновление: March 18, 2026
Библиотека исследований ASH в настоящее время индексирует 269 рецензируемых публикаций по гирудотерапии, охватывая клинические исследования, исходы микрохирургических вмешательств, геномику и протеомику, разработку лекарственных препаратов, фармакологию секрета слюнных желёз, а также безопасность и инфекционный контроль. К каждой статье прилагается полная библиографическая ссылка и ссылка на первоисточник при наличии. Курируемое подмножество (более 50 записей) полностью аннотировано в Hirudopedia по нозологии, уровню доказательности и дизайну исследования.
Доказательная дисциплина
Категории исследований
Антимикробная резистентность
Антимикробные пептиды, синергия с антибиотиками и новые подходы к лекарственно-устойчивым патогенам.
248 статей
Фармакология секрета слюнных желёз
Биоактивные соединения секрета слюнных желёз пиявки — открытие, характеризация и терапевтический потенциал.
968 статей
Разработка лекарственных препаратов
Трансляция соединений, выделенных из пиявок, от лаборатории к клинической практике.
3 264 статьи
Клинические исследования
Рандомизированные контролируемые исследования и систематические обзоры исходов гирудотерапии.
6 472 статьи
Безопасность и инфекционный контроль
Эпидемиологический надзор Aeromonas, протоколы антибиотикопрофилактики и данные о нежелательных явлениях.
1 000 статей
Геномика и протеомика
Открытие новых белков слюнных желёз пиявок методами омикс-технологий и их функциональная характеризация.
808 статей
Все статьи
Showing the 24 most recently added articles. Search or browse all 10,059 articles in the Smart Library (faceted search by topic, evidence grade, year, and verification status), or by category above.
Function of the waterfowl nests as reproduction and living areas for leeches (Annelida: Hirudinea)
Геномика и протеомикаCeylan et al. (2021) — Animal reproduction science
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Correction to: Bacterial Community of the Digestive Tract of the European Medicinal Leech (Hirudo verbana) from the Danube River
Безопасность и инфекционный контрольNeupane et al. (2019) — Microbial ecology
Peer-reviewed safety and infection-control research relevant to leech therapy and microsurgical wound management. Indexed in PubMed and verified against the NCBI record.
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Draft Genome Sequence of Pedobacter sp. Strain Hv1, an Isolate from Medicinal Leech Mucosal Castings
Геномика и протеомикаOtt et al. (2015) — Genome announcements
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Effect of medicinal leeches' antigens on the proliferative response of human blood mononuclear cells and cytokine production in vitro
Клинические исследованияFrolov et al. (2015) — Annals of parasitology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Complete Genome Sequence of the Novel Leech Symbiont Mucinivorans hirudinis M3T
Геномика и протеомикаNelson et al. (2015) — Genome announcements
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Spatial and temporal population dynamics of a naturally occurring two-species microbial community inside the digestive tract of the medicinal leech
Геномика и протеомикаKikuchi et al. (2007) — Applied and environmental microbiology
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Venous engorged tissue flaps treated with medicinal leeches
Клинические исследованияRodgers et al. (1992) — Ophthalmic plastic and reconstructive surgery
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Leech therapy in the management of acute venous congestion of an infant's lower limb
Клинические исследованияWeinfeld et al. (1998) — Plastic and reconstructive surgery
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Bivalirudin for unsalvageable venous congestion or obstruction in head and neck free flap reconstruction
Разработка лекарственных препаратовHarris et al. (2024) — Oral oncology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Recombinant hirudin and PAR-1 regulate macrophage polarisation status in diffuse large B-cell lymphoma
Разработка лекарственных препаратовPei et al. (2024) — BMC biotechnology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Comment on: Bivalirudin during thrombolysis with catheter-directed tPA in a heparin-refractory patient: A case report
Разработка лекарственных препаратовHan (2024) — Pediatric blood & cancer
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Bivalirudin: The misunderstood alternative to heparin
Разработка лекарственных препаратовFaraoni et al. (2024) — Paediatric anaesthesia
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Unresponsiveness of Activated Partial Thromboplastin Time to Bivalirudin in Adults Receiving Extracorporeal Membrane Oxygenation
Разработка лекарственных препаратовJatis et al. (2024) — ASAIO journal (American Society for Artificial Internal Organs : 1992)
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Protein-Engineered Hirudins with Enhanced Anticoagulant Activities Developed by a Molecular Integrative Approach
Клинические исследованияSun et al. (2024) — Journal of medicinal chemistry
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Use of bivalirudin after initial heparin management among adult patients on long-term venovenous extracorporeal support as a bridge to lung transplant: A case series
Разработка лекарственных препаратовHalawi et al. (2024) — Pharmacotherapy
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Bivalirudin Stability in Citrated Plasma and Citrated Whole Blood
Разработка лекарственных препаратовBruzdoski et al. (2024) — Archives of pathology & laboratory medicine
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Comparison of bleeding and thrombotic outcomes in veno-venous extracorporeal membrane oxygenation: Heparin versus bivalirudin
Разработка лекарственных препаратовKartika et al. (2024) — European journal of haematology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Management of Bivalirudin Dosing and Replacement Fluid During Therapeutic Plasma Exchange in Children on Extracorporeal Membrane Oxygenation
Разработка лекарственных препаратовChomat et al. (2024) — ASAIO journal (American Society for Artificial Internal Organs : 1992)
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Editorial: Bivalirudin versus unfractionated heparin in acute myocardial infarction: Why are we still debating?
Разработка лекарственных препаратовCohen et al. (2024) — Cardiovascular revascularization medicine : including molecular interventions
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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One-year clinical outcomes of bivalirudin versus unfractionated heparin in patients with type 2 diabetes undergoing elective percutaneous coronary intervention
Разработка лекарственных препаратовLi et al. (2023) — Diabetes & metabolic syndrome
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Editorial: Bivalirudin with post-procedural infusion: Should the Guidelines change to keep up with the data?
Разработка лекарственных препаратовLipinski (2023) — Cardiovascular revascularization medicine : including molecular interventions
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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The effect of bivalirudin on coagulation function in male patients with coronary heart disease undergoing percutaneous coronary intervention
Разработка лекарственных препаратовDequan et al. (2023) — Pakistan journal of pharmaceutical sciences
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Anticoagulation strategies in patients with extracorporeal membrane oxygenation: A network meta-analysis and systematic review
Клинические исследованияChen et al. (2023) — Pharmacotherapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Anticoagulation Management in Temporary Mechanical Circulatory Support Devices
Клинические исследованияYin (2023) — Texas Heart Institute journal
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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