Библиотека исследований
Курируемые обзоры рецензируемых исследований, имеющих отношение к гирудотерапии
Последнее обновление: March 14, 2026
Библиотека исследований ASH содержит углублённые обзоры значимых рецензируемых публикаций, имеющих отношение к гирудотерапии. Каждая статья контекстуализирована с точки зрения клинической и трансляционной значимости, с полным цитированием и ссылками на первоисточники.
Дисциплина доказательности
Категории исследований
Antimicrobial Resistance
AMPs, antibiotic synergy, and novel approaches to drug-resistant pathogens.
1 статья
Salivary Pharmacology
Bioactive compounds in leech saliva — discovery, characterization, and therapeutic potential.
3 статьи
Drug Development
Bench-to-bedside translation of leech-derived compounds.
2 статьи
Clinical Trials
Randomized controlled trials and systematic reviews of leech therapy outcomes.
2 статьи
Safety & Infection Control
Aeromonas surveillance, prophylaxis protocols, and adverse event data.
1 статья
Genomics & Proteomics
Omics-based discovery of novel leech salivary proteins and their functions.
2 статьи
Все статьи
Novel Leech Antimicrobial Peptides — Hirunipins
Antimicrobial ResistanceKumar et al. (2025) — Advanced Science (Wiley)
First characterization of hirunipins — novel cysteine-rich antimicrobial peptides from Hirudo medicinalis saliva with activity against multidrug-resistant bacteria, biofilm disruption capability, and synergy with conventional antibiotics.
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Leech Therapy for Knee Osteoarthritis — The Landmark RCT
Clinical TrialsMichalsen et al. (2003) — Annals of Internal Medicine
Landmark randomized controlled trial demonstrating that a single application of 4–6 leeches to the knee provided significant pain reduction (WOMAC −48%) lasting 3–6 months, with outcomes superior to topical diclofenac.
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Leech-Assisted Flap Salvage — Systematic Review of 277 Cases
Clinical TrialsWhitaker et al. (2012) — Microsurgery
Systematic review of 277 cases across 67 publications (1966–2009) establishing the evidence base for the FDA-cleared indication. Overall flap salvage rate 60–83%, with Aeromonas infection reducing salvage from 88.3% to 37.4%.
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434 Salivary Proteins — Integrated Proteomics of Hirudo medicinalis
Genomics & ProteomicsLiu et al. (2019) — Journal of Proteomics
Integrated proteomics and transcriptomics study identifying 434 full-length protein sequences from H. medicinalis salivary glands, including 44 confirmed bioactive proteins and 221 bioactive transcripts across 6 functional categories.
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Medicinal Leech Genome Assembly — Anticoagulant Gene Catalog
Genomics & ProteomicsKvist et al. (2020) — Scientific Reports
First chromosome-level genome assembly for Hirudo medicinalis (176.96 Mbp on 19,929 scaffolds) with annotated catalog of 15 anticoagulation factors and 17 antihemostatic proteins, including novel candidates like Lefaxin.
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