Библиотека исследований
Курируемые обзоры рецензируемых исследований, имеющих отношение к гирудотерапии
ASH structured research registries
In addition to 10051+ long-form research articles below, ASH curates 5 structured registries with cross-linking:
Editorial transparency & research roadmap
ASH treats this library as a living dataset. Current import baseline: 10051 long-form articles plus 449 metadata-imported PubMed/DOI records, with a public 10,000-article ingestion target. The pages below explain how we grade evidence, what PMIDs are still unverified, and where the corpus is going next.
Последнее обновление: June 18, 2026
Библиотека исследований ASH в настоящее время индексирует 269 рецензируемых публикаций по гирудотерапии, охватывая клинические исследования, исходы микрохирургических вмешательств, геномику и протеомику, разработку лекарственных препаратов, фармакологию секрета слюнных желёз, а также безопасность и инфекционный контроль. К каждой статье прилагается полная библиографическая ссылка и ссылка на первоисточник при наличии. Курируемое подмножество (более 50 записей) полностью аннотировано в Hirudopedia по нозологии, уровню доказательности и дизайну исследования.
Доказательная дисциплина
Категории исследований
Антимикробная резистентность
Антимикробные пептиды, синергия с антибиотиками и новые подходы к лекарственно-устойчивым патогенам.
248 статей
Фармакология секрета слюнных желёз
Биоактивные соединения секрета слюнных желёз пиявки — открытие, характеризация и терапевтический потенциал.
967 статей
Разработка лекарственных препаратов
Трансляция соединений, выделенных из пиявок, от лаборатории к клинической практике.
3 263 статьи
Клинические исследования
Рандомизированные контролируемые исследования и систематические обзоры исходов гирудотерапии.
6 465 статей
Безопасность и инфекционный контроль
Эпидемиологический надзор Aeromonas, протоколы антибиотикопрофилактики и данные о нежелательных явлениях.
994 статьи
Геномика и протеомика
Открытие новых белков слюнных желёз пиявок методами омикс-технологий и их функциональная характеризация.
807 статей
Все статьи
Recent research articles carrying original, peer-reviewed ASH analysis. See the full index of all 2,460 analysed articles, or search the complete 10,051-article corpus in the Smart Library (faceted by topic, evidence grade, year, and verification status).
Comparison of bleeding and thrombotic outcomes in veno-venous extracorporeal membrane oxygenation: Heparin versus bivalirudin
Разработка лекарственных препаратовKartika et al. (2024) — European journal of haematology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices
Разработка лекарственных препаратовPappalardo et al. (2012) — Minerva anestesiologica
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Heparin-induced thrombosis with a normal platelet count
Клинические исследованияAlvarez et al. (2007) — Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Effects of Bivalirudin and Unfractionated Heparin on Liver and Renal Function in Chinese Patients with Coronary Artery Disease Undergoing Coronary Angiography with/without Percutaneous Coronary Intervention
Разработка лекарственных препаратовJia et al. (2021) — Journal of clinical and translational hepatology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Association Between Argatroban and Outcomes of Branch Atheromatous Disease: A Propensity-Matched Analysis From MRI-Based Study
Разработка лекарственных препаратовLi et al. (2025) — CNS neuroscience & therapeutics
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Safety and efficacy of argatroban combined with antiplatelet therapy for acute mild-to-moderate ischemic stroke with large artery atherosclerosis
Разработка лекарственных препаратовYan et al. (2025) — Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Delayed-onset eptifibatide-induced thrombocytopenia
Клинические исследованияHuffman et al. (2024) — American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Clinical impact of kidney function in patients with atrial fibrillation receiving oral anticoagulants
Клинические исследованияMatsuoka et al. (2025) — International journal of cardiology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Renal outcomes following oral anticoagulation in non-valvular atrial fibrillation: A multicentre, propensity-matched retrospective analysis in an Asian population
Клинические исследованияKoh et al. (2025) — Asian cardiovascular & thoracic annals
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Effectiveness and Safety in Patients with Non-Valvular Atrial Fibrillation Who Switched from Warfarin to Direct Oral Anticoagulants in Medicare Population
Клинические исследованияAtreja et al. (2025) — Advances in therapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Population pharmacokinetics of unfractionated heparin and multivariable analysis of activated clotting time in patients undergoing radiofrequency ablation of atrial fibrillation
Разработка лекарственных препаратовKonecki et al. (2024) — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Bleeding Associated With Antiarrhythmic Drugs in Patients With Atrial Fibrillation Using Direct Oral Anticoagulants: A Nationwide Population Cohort Study
Клинические исследованияWu et al. (2024) — Journal of the American Heart Association
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Comparing Efficacy and Safety of Different Anticoagulants in Cerebral Venous Thrombosis: A Systematic Review and Network Meta-Analysis
Клинические исследованияWaseem et al. (2026) — Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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PROS1 (Cys228Tyr) missense mutation associated with mesenteric and pulmonary venous thromboembolism during the COVID-19 pandemic: a case report
Клинические исследованияHuang et al. (2025) — Frontiers in cardiovascular medicine
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Comparison of VTE prophylaxis agents on hemoglobin levels after total knee arthroplasty: a hospital information system-based observational study
Безопасность и инфекционный контрольYuan et al. (2025) — Journal of orthopaedic surgery and research
Peer-reviewed safety and infection-control research relevant to leech therapy and microsurgical wound management. Indexed in PubMed and verified against the NCBI record.
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Upper Extremity Deep Vein Thrombosis Secondary to Gastric Cancer: A Case Report
Клинические исследованияTakano et al. (2026) — Cureus
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Treatment of cancer-associated thrombosis: The evolution of anticoagulant choice and clinical insights into practical management
Клинические исследованияRiess et al. (2021) — Critical reviews in oncology/hematology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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An update on the efficacy and safety of novel anticoagulants for cancer associated thrombosis
Клинические исследованияCosmi (2021) — Expert opinion on pharmacotherapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Efficacy and safety of Xa inhibitors for the treatment of cancer-associated venous thromboembolism
Разработка лекарственных препаратовKimpton et al. (2019) — Expert opinion on drug safety
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Peak and Trough Concentration Ranges of Factor Xa Inhibitors for Preventing Thromboembolic Stroke in Korean Patients with Non-valvular Atrial Fibrillation
Разработка лекарственных препаратовPark et al. (2026) — Annals of laboratory medicine
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Real-world evidence comparing oral anticoagulants for NVAF in Europe: a systematic review and network meta-analysis
Клинические исследованияCichewicz et al. (2025) — Future cardiology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Edoxaban-Induced Vanishing Bile Duct Syndrome: A Case Report With Review of the Literature
Разработка лекарственных препаратовBorgonovo et al. (2024) — Cureus
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Optimizing warfarin dosing for patients with atrial fibrillation using machine learning
Разработка лекарственных препаратовPetch et al. (2024) — Scientific reports
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Leech-borne Serratia marcescens infection following complex hand injury.
Безопасность и инфекционный контрольPereira et al. (1998) — British journal of plastic surgery
Leeches are commonly used in the postoperative course of plastic surgical operations where there is venous congestion in a pedicled or free flap. They provide a temporary relief to venous engorgement whilst venous drainage is re-established.
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