Intelligente Bibliothek

The most potent natural thrombin inhibitor — and the molecular template for three FDA-approved direct thrombin inhibitor drugs.

Anti-platelet adhesion protein that blocks von Willebrand factor–collagen binding.

Anti-platelet adhesion protein blocking collagen-mediated platelet activation.

Lysozyme with isopeptidase activity that dissolves stabilized fibrin clots — including aged thrombi resistant to tPA.

Factor Xa inhibitor — prototype molecule that inspired the entire DOAC drug class (rivaroxaban, apixaban).

RGD-containing peptide inhibiting platelet GP IIb/IIIa receptor — eptifibatide ancestor.

RGD-peptide GP IIb/IIIa antagonist — sister molecule to decorsin from a different leech species.

Direct fibrinogenolytic enzyme — degrades fibrinogen independently of plasmin.

Factor Xa inhibitor with anti-metastatic activity in animal cancer models — translational dual-use compound.

Factor Xa inhibitor with anti-inflammatory properties.

Hirudin variant from Hirudinaria manillensis with distinct kinetics.

Synthetic hirudin variant with improved oral pharmacokinetics — preclinical anticoagulant.

Inhibitor of TAFI (thrombin-activatable fibrinolysis inhibitor) — synergizes with hirudin's anticoagulant action.

Synthetic 20-amino-acid hirudin analog — FDA-approved direct thrombin inhibitor for PCI anticoagulation ($636M peak revenue).

First-generation recombinant hirudin — FDA-approved 1998 for heparin-induced thrombocytopenia (HIT). Withdrawn 2012 by Bayer for commercial reasons.

Recombinant hirudin variant — FDA-approved 2003 for prophylaxis of DVT after hip replacement surgery.

Oral direct thrombin inhibitor — FDA approved 2010 for stroke prevention in atrial fibrillation. Conceptual descendant of hirudin pharmacology.

Synthetic small-molecule direct thrombin inhibitor — FDA approved 2000 for HIT and PCI. Designed using hirudin structural insights.

Oral Factor Xa inhibitor — FDA approved 2011. Conceptual descendant of antistasin/leech FXa research.

Oral Factor Xa inhibitor — FDA approved 2012. Part of the DOAC class inspired by leech antistasin discovery.

Oral Factor Xa inhibitor — FDA approved 2015. Latest of the antistasin-inspired DOAC class.

Cyclic heptapeptide GP IIb/IIIa receptor antagonist — FDA approved 1998. Structural inspiration: leech decorsin.

Direct fibrinogenolytic enzyme cleaving fibrinogen alpha-chain at unique sites — independent of plasmin.

Leech-derived inhibitor that potentiates host antithrombin III activity — synergistic anticoagulation.

Factor Xa inhibitor from Theromyzon tessulatum — Kunitz-domain analog with novel selectivity profile.

Picomolar-affinity thrombin inhibitor from Indian buffalo leech — distinct mechanism from hirudin.

Factor XIIIa inhibitor — blocks fibrin cross-linking; novel mechanism distinct from hirudin.

Platelet GP IIb/IIIa antagonist family member — RGD-motif containing.

Isopeptidase domain of destabilase that cleaves cross-linked fibrin — distinct from lysozyme domain.

ADP-degrading enzyme — prevents platelet aggregation by hydrolyzing ADP at bite site.

Inhibitor of tissue factor / Factor VIIa complex — blocks extrinsic coagulation pathway.

Modulates the thrombin-thrombomodulin axis — implications for protein C pathway.

Trypsin and Factor Xa inhibitor with broad-spectrum serine protease activity.

Direct thrombin inhibitor from the Asian buffalo leech — hirudin homolog described in Hirudinaria manillensis secretome.

Anticoagulant peptide described in the terrestrial Asian leech Haemadipsa zeylanica.

Direct thrombin inhibitor homolog cataloged in the Chinese medicinal leech Whitmania pigra secretome.

Small direct thrombin inhibitor described in the fish leech Piscicola geometra secretome.

Anticoagulant peptide described in the North American medicinal leech Macrobdella decora.

Isoform of saratin — collagen-binding anti-platelet protein from Hirudo medicinalis.

Fibrinogenolytic / anti-platelet protein homologous to hementin — disrupts platelet aggregation.

Isoform of LAPP — collagen-binding inhibitor of platelet adhesion.

Salivary protein blocking platelet adhesion to extracellular matrix components.

Second isoform of destabilase — lysozyme / isopeptidase activity targeting cross-linked fibrin.

Alternate fibrin-cleaving enzyme reported in Hirudo medicinalis salivary secretions.

Dual-function protease degrading both fibrin clot scaffolds and collagen extracellular matrix.

Non-hirudin thrombin inhibitor from the rhynchobdellid leech Theromyzon tessulatum — highest-affinity natural inhibitor identified in a non-Hirudo species.

Collagen-binding antiplatelet variant from the Hirudo medicinalis sialotranscriptome — paralog of saratin and saratin-2.

Small thrombin-inhibitor peptide identified in the Hirudo medicinalis salivary transcriptome — truncated hirudin-family analog.

Antiplatelet peptide identified in leech salivary transcriptome — inhibits platelet aggregation in vitro.

Paralog of gelin identified in the Hirudo medicinalis sialotranscriptome — putative antiplatelet variant.