Piscicolin
Small direct thrombin inhibitor described in the fish leech Piscicola geometra secretome.
Praeklinisch / mechanistischLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Small direct thrombin inhibitor described in the fish leech Piscicola geometra secretome.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
Piscicolin is documented mechanistically only; no human evidence. Piscicola geometra is not used clinically on humans, and piscicolin has no FDA-approved derivative.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Molecular weight
- 5,500 Da
- Source species
- Piscicola geometra
- Discovered
- 2015
Biological Targets
- → thrombin (Factor IIa)
External Resources
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