Forschungsbibliothek
Kuratierte Übersichten peer-reviewter Forschung mit Relevanz für die Hirudotherapie
ASH structured research registries
In addition to 10059+ long-form research articles below, ASH curates 5 structured registries with cross-linking:
Editorial transparency & research roadmap
ASH treats this library as a living dataset. Current import baseline: 10059 long-form articles plus 449 metadata-imported PubMed/DOI records, with a public 10,000-article ingestion target. The pages below explain how we grade evidence, what PMIDs are still unverified, and where the corpus is going next.
Letzte Aktualisierung: June 18, 2026
Die ASH-Forschungsbibliothek indexiert derzeit 269 peer-reviewte Publikationen mit Relevanz für die Hirudotherapie und umfasst klinische Studien, mikrochirurgische Ergebnisse, Genomik & Proteomik, Arzneimittelentwicklung, Speichel-Pharmakologie sowie Sicherheit & Infektionskontrolle. Jeder Artikel enthält eine vollständige Zitation sowie – sofern verfügbar – einen Link zur Primärquelle. Eine kuratierte Auswahl (50+ Einträge) ist in Hirudopedia nach Indikation, Evidenzgrad und Studiendesign vollständig annotiert.
Evidenz-Disziplin
Forschungskategorien
Antimikrobielle Resistenz
AMPs, Antibiotika-Synergie und neuartige Ansätze gegen arzneimittelresistente Pathogene.
248 Artikel
Speichel-Pharmakologie
Bioaktive Verbindungen im Blutegelspeichel – Entdeckung, Charakterisierung und therapeutisches Potenzial.
968 Artikel
Arzneimittelentwicklung
Translation blutegelabgeleiteter Verbindungen vom Labor in die klinische Anwendung.
3.264 Artikel
Klinische Studien
Randomisierte kontrollierte Studien und systematische Übersichtsarbeiten zu Ergebnissen der Blutegeltherapie.
6.472 Artikel
Sicherheit & Infektionskontrolle
Aeromonas-Überwachung, Prophylaxe-Protokolle und Daten zu unerwünschten Ereignissen.
1.000 Artikel
Genomik & Proteomik
Omics-basierte Entdeckung neuartiger Speichelproteine des Blutegels und ihrer Funktionen.
808 Artikel
Alle Artikel
Showing the 24 most recently added articles. Search or browse all 10,059 articles in the Smart Library (faceted search by topic, evidence grade, year, and verification status), or by category above.
Function of the waterfowl nests as reproduction and living areas for leeches (Annelida: Hirudinea)
Genomik & ProteomikCeylan et al. (2021) — Animal reproduction science
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Correction to: Bacterial Community of the Digestive Tract of the European Medicinal Leech (Hirudo verbana) from the Danube River
Sicherheit & InfektionskontrolleNeupane et al. (2019) — Microbial ecology
Peer-reviewed safety and infection-control research relevant to leech therapy and microsurgical wound management. Indexed in PubMed and verified against the NCBI record.
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Draft Genome Sequence of Pedobacter sp. Strain Hv1, an Isolate from Medicinal Leech Mucosal Castings
Genomik & ProteomikOtt et al. (2015) — Genome announcements
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Effect of medicinal leeches' antigens on the proliferative response of human blood mononuclear cells and cytokine production in vitro
Klinische StudienFrolov et al. (2015) — Annals of parasitology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Complete Genome Sequence of the Novel Leech Symbiont Mucinivorans hirudinis M3T
Genomik & ProteomikNelson et al. (2015) — Genome announcements
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Spatial and temporal population dynamics of a naturally occurring two-species microbial community inside the digestive tract of the medicinal leech
Genomik & ProteomikKikuchi et al. (2007) — Applied and environmental microbiology
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
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Venous engorged tissue flaps treated with medicinal leeches
Klinische StudienRodgers et al. (1992) — Ophthalmic plastic and reconstructive surgery
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Leech therapy in the management of acute venous congestion of an infant's lower limb
Klinische StudienWeinfeld et al. (1998) — Plastic and reconstructive surgery
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Bivalirudin for unsalvageable venous congestion or obstruction in head and neck free flap reconstruction
ArzneimittelentwicklungHarris et al. (2024) — Oral oncology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Recombinant hirudin and PAR-1 regulate macrophage polarisation status in diffuse large B-cell lymphoma
ArzneimittelentwicklungPei et al. (2024) — BMC biotechnology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Comment on: Bivalirudin during thrombolysis with catheter-directed tPA in a heparin-refractory patient: A case report
ArzneimittelentwicklungHan (2024) — Pediatric blood & cancer
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Bivalirudin: The misunderstood alternative to heparin
ArzneimittelentwicklungFaraoni et al. (2024) — Paediatric anaesthesia
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Unresponsiveness of Activated Partial Thromboplastin Time to Bivalirudin in Adults Receiving Extracorporeal Membrane Oxygenation
ArzneimittelentwicklungJatis et al. (2024) — ASAIO journal (American Society for Artificial Internal Organs : 1992)
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Protein-Engineered Hirudins with Enhanced Anticoagulant Activities Developed by a Molecular Integrative Approach
Klinische StudienSun et al. (2024) — Journal of medicinal chemistry
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Use of bivalirudin after initial heparin management among adult patients on long-term venovenous extracorporeal support as a bridge to lung transplant: A case series
ArzneimittelentwicklungHalawi et al. (2024) — Pharmacotherapy
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Bivalirudin Stability in Citrated Plasma and Citrated Whole Blood
ArzneimittelentwicklungBruzdoski et al. (2024) — Archives of pathology & laboratory medicine
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Comparison of bleeding and thrombotic outcomes in veno-venous extracorporeal membrane oxygenation: Heparin versus bivalirudin
ArzneimittelentwicklungKartika et al. (2024) — European journal of haematology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Management of Bivalirudin Dosing and Replacement Fluid During Therapeutic Plasma Exchange in Children on Extracorporeal Membrane Oxygenation
ArzneimittelentwicklungChomat et al. (2024) — ASAIO journal (American Society for Artificial Internal Organs : 1992)
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Editorial: Bivalirudin versus unfractionated heparin in acute myocardial infarction: Why are we still debating?
ArzneimittelentwicklungCohen et al. (2024) — Cardiovascular revascularization medicine : including molecular interventions
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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One-year clinical outcomes of bivalirudin versus unfractionated heparin in patients with type 2 diabetes undergoing elective percutaneous coronary intervention
ArzneimittelentwicklungLi et al. (2023) — Diabetes & metabolic syndrome
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Editorial: Bivalirudin with post-procedural infusion: Should the Guidelines change to keep up with the data?
ArzneimittelentwicklungLipinski (2023) — Cardiovascular revascularization medicine : including molecular interventions
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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The effect of bivalirudin on coagulation function in male patients with coronary heart disease undergoing percutaneous coronary intervention
ArzneimittelentwicklungDequan et al. (2023) — Pakistan journal of pharmaceutical sciences
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Anticoagulation strategies in patients with extracorporeal membrane oxygenation: A network meta-analysis and systematic review
Klinische StudienChen et al. (2023) — Pharmacotherapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Anticoagulation Management in Temporary Mechanical Circulatory Support Devices
Klinische StudienYin (2023) — Texas Heart Institute journal
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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