Forschungsbibliothek
Kuratierte Übersichten peer-reviewter Forschung mit Relevanz für die Hirudotherapie
ASH structured research registries
In addition to 10051+ long-form research articles below, ASH curates 5 structured registries with cross-linking:
Editorial transparency & research roadmap
ASH treats this library as a living dataset. Current import baseline: 10051 long-form articles plus 449 metadata-imported PubMed/DOI records, with a public 10,000-article ingestion target. The pages below explain how we grade evidence, what PMIDs are still unverified, and where the corpus is going next.
Die ASH-Forschungsbibliothek indexiert derzeit 269 peer-reviewte Publikationen mit Relevanz für die Hirudotherapie und umfasst klinische Studien, mikrochirurgische Ergebnisse, Genomik & Proteomik, Arzneimittelentwicklung, Speichel-Pharmakologie sowie Sicherheit & Infektionskontrolle. Jeder Artikel enthält eine vollständige Zitation sowie – sofern verfügbar – einen Link zur Primärquelle. Eine kuratierte Auswahl (50+ Einträge) ist in Hirudopedia nach Indikation, Evidenzgrad und Studiendesign vollständig annotiert.
Evidenz-Disziplin
Forschungskategorien
Antimikrobielle Resistenz
AMPs, Antibiotika-Synergie und neuartige Ansätze gegen arzneimittelresistente Pathogene.
248 Artikel
Speichel-Pharmakologie
Bioaktive Verbindungen im Blutegelspeichel – Entdeckung, Charakterisierung und therapeutisches Potenzial.
967 Artikel
Arzneimittelentwicklung
Translation blutegelabgeleiteter Verbindungen vom Labor in die klinische Anwendung.
3.263 Artikel
Klinische Studien
Randomisierte kontrollierte Studien und systematische Übersichtsarbeiten zu Ergebnissen der Blutegeltherapie.
6.465 Artikel
Sicherheit & Infektionskontrolle
Aeromonas-Überwachung, Prophylaxe-Protokolle und Daten zu unerwünschten Ereignissen.
994 Artikel
Genomik & Proteomik
Omics-basierte Entdeckung neuartiger Speichelproteine des Blutegels und ihrer Funktionen.
807 Artikel
Alle Artikel
Recent research articles carrying original, peer-reviewed ASH analysis. See the full index of all 2,552 analysed articles, or search the complete 10,051-article corpus in the Smart Library (faceted by topic, evidence grade, year, and verification status).
Comparison of bleeding and thrombotic outcomes in veno-venous extracorporeal membrane oxygenation: Heparin versus bivalirudin
ArzneimittelentwicklungKartika et al. (2024) — European journal of haematology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices
ArzneimittelentwicklungPappalardo et al. (2012) — Minerva anestesiologica
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Heparin-induced thrombosis with a normal platelet count
Klinische StudienAlvarez et al. (2007) — Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Effects of Bivalirudin and Unfractionated Heparin on Liver and Renal Function in Chinese Patients with Coronary Artery Disease Undergoing Coronary Angiography with/without Percutaneous Coronary Intervention
ArzneimittelentwicklungJia et al. (2021) — Journal of clinical and translational hepatology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Association Between Argatroban and Outcomes of Branch Atheromatous Disease: A Propensity-Matched Analysis From MRI-Based Study
ArzneimittelentwicklungLi et al. (2025) — CNS neuroscience & therapeutics
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Safety and efficacy of argatroban combined with antiplatelet therapy for acute mild-to-moderate ischemic stroke with large artery atherosclerosis
ArzneimittelentwicklungYan et al. (2025) — Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Delayed-onset eptifibatide-induced thrombocytopenia
Klinische StudienHuffman et al. (2024) — American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Clinical impact of kidney function in patients with atrial fibrillation receiving oral anticoagulants
Klinische StudienMatsuoka et al. (2025) — International journal of cardiology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Renal outcomes following oral anticoagulation in non-valvular atrial fibrillation: A multicentre, propensity-matched retrospective analysis in an Asian population
Klinische StudienKoh et al. (2025) — Asian cardiovascular & thoracic annals
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Effectiveness and Safety in Patients with Non-Valvular Atrial Fibrillation Who Switched from Warfarin to Direct Oral Anticoagulants in Medicare Population
Klinische StudienAtreja et al. (2025) — Advances in therapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Population pharmacokinetics of unfractionated heparin and multivariable analysis of activated clotting time in patients undergoing radiofrequency ablation of atrial fibrillation
ArzneimittelentwicklungKonecki et al. (2024) — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Bleeding Associated With Antiarrhythmic Drugs in Patients With Atrial Fibrillation Using Direct Oral Anticoagulants: A Nationwide Population Cohort Study
Klinische StudienWu et al. (2024) — Journal of the American Heart Association
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Comparing Efficacy and Safety of Different Anticoagulants in Cerebral Venous Thrombosis: A Systematic Review and Network Meta-Analysis
Klinische StudienWaseem et al. (2026) — Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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PROS1 (Cys228Tyr) missense mutation associated with mesenteric and pulmonary venous thromboembolism during the COVID-19 pandemic: a case report
Klinische StudienHuang et al. (2025) — Frontiers in cardiovascular medicine
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Comparison of VTE prophylaxis agents on hemoglobin levels after total knee arthroplasty: a hospital information system-based observational study
Sicherheit & InfektionskontrolleYuan et al. (2025) — Journal of orthopaedic surgery and research
Peer-reviewed safety and infection-control research relevant to leech therapy and microsurgical wound management. Indexed in PubMed and verified against the NCBI record.
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Upper Extremity Deep Vein Thrombosis Secondary to Gastric Cancer: A Case Report
Klinische StudienTakano et al. (2026) — Cureus
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Treatment of cancer-associated thrombosis: The evolution of anticoagulant choice and clinical insights into practical management
Klinische StudienRiess et al. (2021) — Critical reviews in oncology/hematology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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An update on the efficacy and safety of novel anticoagulants for cancer associated thrombosis
Klinische StudienCosmi (2021) — Expert opinion on pharmacotherapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Efficacy and safety of Xa inhibitors for the treatment of cancer-associated venous thromboembolism
ArzneimittelentwicklungKimpton et al. (2019) — Expert opinion on drug safety
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Peak and Trough Concentration Ranges of Factor Xa Inhibitors for Preventing Thromboembolic Stroke in Korean Patients with Non-valvular Atrial Fibrillation
ArzneimittelentwicklungPark et al. (2026) — Annals of laboratory medicine
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Real-world evidence comparing oral anticoagulants for NVAF in Europe: a systematic review and network meta-analysis
Klinische StudienCichewicz et al. (2025) — Future cardiology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Edoxaban-Induced Vanishing Bile Duct Syndrome: A Case Report With Review of the Literature
ArzneimittelentwicklungBorgonovo et al. (2024) — Cureus
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Optimizing warfarin dosing for patients with atrial fibrillation using machine learning
ArzneimittelentwicklungPetch et al. (2024) — Scientific reports
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Leech-borne Serratia marcescens infection following complex hand injury.
Sicherheit & InfektionskontrollePereira et al. (1998) — British journal of plastic surgery
Leeches are commonly used in the postoperative course of plastic surgical operations where there is venous congestion in a pedicled or free flap. They provide a temporary relief to venous engorgement whilst venous drainage is re-established.
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