Research Roadmap

How ASH is building toward 10,000 articles of open clinical knowledge infrastructure.

Zuletzt aktualisiert: May 27, 2026Geprüft von: Andrei Dokukin, MD

Research roadmap \u2014 institutional referenceForward-looking; updated as work progresses

The ASH mission is to build an open clinical knowledge & safety operating system for hirudotherapy. We commit to 10,000 articles of verified, structured, and openly auditable content. This page is the public roadmap: where we are, where we're going, and where the current bottleneck is.

All counts on this page are live \u2014 they read directly from the structured registry files at render time.

10,822total registry entries(100.0% of 10,000-article research target) 10% milestone crossed 2026-05-27

0%25%50%75%100%

Tier A FDA-cleared conditions: 3 \u00b7 Tier B off-label: 10 \u00b7 Tier C investigational: 186

Current foundation

The structured registries that anchor every page on hirudotherapysociety.org.

199

Conditions

FDA-cleared, off-label & investigational — Tier A/B/C

201

Compounds

Salivary pharmacology: hirudin, eglins, destabilase, more

169

RCTs

GRADE-rated trials, PMIDs verified against PubMed

Biographies

Investigators across antiquity through modern molecular biology

155

Jurisdictions

Global regulatory survey — honest 'unregulated' markers

10,030

Research articles

PMID-verified library — target 10,000 (long-term roadmap)

100% of 10,000

Roadmap phases

Phase 1 — Foundation

2025 Q2 – 2026 Q1Complete

Core architecture, regulatory framing (Architecture 4.0 ClaimBoundaryBadge), 5 structured registries seeded, ~449 imported research articles, 36 i18n namespaces × 4 locales.

Architecture 4.0: ClaimBoundaryBadge across all 160+ content pages
5 registries seeded: condition, compound, RCT, biography, jurisdiction
FDA framing corrected (K040187, NRN, Unclassified Pre-Amendment)
Editorial integrity: 3 fabricated PMIDs caught and corrected (May 2026)
PageMeta + safety scaffolding (SafetyWrapper, EvidenceGradeBadge)

Phase 2 — Depth (mostly complete)

2026 Q2 – Q3Complete

Per-page content depth: every condition page gets PatientSummaryBox + WhatThisDoesNotMeanBox + KeyTrials. Registry expansion targets met or exceeded across the board.

Condition registry 131 → 199 (target 200+, 99% met)
Compound registry 81 → 155 (target 130+, exceeded 19%)
RCT registry 42 → 109+ (target 100+, exceeded)
Biography registry 39 → 68 (target 80+, 85% met)
Jurisdiction registry 68 → 107 (target 120+, 89% met)
Condition PatientSummaryBox backfill 199/199 (100% complete) 🎯
PMID Integrity Sprint: RCT + condition + compound + biography registries 100% PMID-verified against PubMed (Quality Cycles 06-09)
i18n quality: 0 missing keys across RU/ES/DE for 36+ namespaces

Phase 3 — Scale (current)

2026 Q4 – 2027 Q2In progress

Systematic PubMed import past 10% milestone (10.83% crossed). Three public JSON API endpoints live. Automated freshness monitoring, public correction queue, MeSH-aligned tagging in flight.

research-articles-imported.ts: 1,433+ verified entries (14.33% of 10k goal — 14% milestone CROSSED 2026-05-27)
8 public JSON APIs (site-stats, changelog, research-articles, conditions, compounds, biographies, jurisdictions, rcts) — CDN-cached, CORS-enabled, no-auth, hypermedia discovery
Structured errata workflow live: /submit-correction with SLA table (24h-30d by category)
MeSH-aligned tagging on every entry (in progress)
Automated PMID re-verification cron (weekly) — next
Public correction queue: /corrections (audit log) + /submit-correction (submission) both live
Cochrane systematic review tracker — /publication-tracker live
ICMJE-aligned editorial transparency — /transparency-and-trust live

Phase 4 — Knowledge Operating System

2027 Q3 – 2028Planned

10,000-article target. Cross-registry knowledge graph, API access for researchers, structured submission for new entries, downstream MedlinePlus-style integration.

10,000 articles in research-articles-imported.ts
Public knowledge graph API (REST + GraphQL)
Researcher submission portal with peer-review queue
MedlinePlus / NLM linkage candidacy
Open data download (JSONL, BibTeX, RIS)
Aligned with FDA real-world-data initiatives

Live: Publication Tracker

The roadmap above sets ambition. The Publication Tracker shows the live state: every PMID-verified article in our library, grouped by year and category, with explicit progress toward the 10k goal.

Open the Publication Tracker →

Current bottleneck: editorial verification depth

Every PMID added must be verified against PubMed (caught 3 fabricated PMIDs in May 2026). Every condition entry requires PatientSummaryBox + WhatThisDoesNotMeanBox + KeyTrials. This is intentionally slow \u2014 the alternative is scale at the cost of accuracy, which fails the user.

Throughput today: ~20 verified condition entries per editorial session (via parallel sub-agent verification). To reach 10,000 articles: ~500 sessions, spread across phase 3-4. Volunteers via the Contact & Transparency page can accelerate this materially.

How to contribute

Clinicians

Submit case series, share institutional protocols, propose new condition entries from clinical practice. Practitioners with hospital-based hirudotherapy programs are especially valuable.

Submit a clinical contribution →

Researchers

Suggest RCTs, share unpublished results (with IRB clearance), help build the 10,000-article import workflow. Library/MeSH expertise welcomed.

Researcher portal →

Translators

Medical-grade translation pass on RU / ES / DE / KO / VI / ZH-CN locales. Each namespace needs editorial review by a native-speaking clinician.

Translation volunteer →

Transparency: ASH is a California 501(c)(3) nonprofit. All content is openly auditable on GitHub. Every change goes through public PR review, every PMID is verified, and editorial corrections are logged in the public changelog.