Biblioteca Inteligente
Búsqueda facetada en los 5 registros. Filtrar por tipo de registro, nivel de evidencia o dominio de seguridad.
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Esta biblioteca indexa toda la base de evidencia. Para orientarse, comience con las guías esenciales:
Filtros
Nivel de evidencia
Mostrando 62 de 780 entradas. Refine mediante los parámetros de consulta de la URL.
Condiciones
10Úlcera Venosa de la Pierna
Nivel BCoadyuvante off-label de la terapia de compresión con evidencia de serie de casos para cicatrización acelerada en úlceras venosas resistentes a la compresión.
Síndrome Postrombótico
Nivel BUso off-label con evidencia de serie de casos para alivio sintomático del dolor de piernas, pesadez y ulceración en PTS tras trombosis venosa profunda.
Hipertensión Esencial (Adyuvante)
Nivel CUso adyuvante en investigación; el mecanismo incluye diuresis leve por extracción de volumen sanguíneo y efectos vasculares endoteliales mediados por hirudina. No sustituye a la farmacoterapia.
Varices (Tributarias Sintomáticas)
Nivel CUso en investigación para el alivio sintomático de las molestias e inflamación de las tributarias varicosas; no elimina el reflujo venoso subyacente.
Mastitis Lactacional (No Supurativa)
Nivel CUso adyuvante en investigación para la mastitis lactacional no supurativa; evidencia de series de casos para la resolución de la induración y la reducción de los días de antibióticos.
Ciática (No Discogénica / Piriforme)
Nivel CUso en investigación para la ciática no discogénica, incluido el síndrome del piriforme; evidencia de series de casos para la reducción del dolor.
Cicatrices Queloides e Hipertróficas
Nivel CUso en investigación para cicatrices queloides e hipertróficas estables; evidencia de series de casos para ablandamiento y aplanamiento.
Linfedema Post-Mastectomía
Nivel CUso complementario en investigación tras el tratamiento de cáncer de mama con disección de ganglios axilares; evidencia de series de casos para reducción del volumen del brazo.
Síndrome del Túnel Carpiano (Leve-Moderado)
Nivel CUso experimental en el síndrome del túnel carpiano de leve a moderado; no existe ningún ensayo clínico publicado y verificable específico para esta indicación.
Migraña Vestibular (Coadyuvante en Investigación)
Nivel CCoadyuvante en investigación para la migraña vestibular refractaria; la profilaxis de la migraña (propranolol, topiramato, amitriptilina) y la rehabilitación vestibular siguen siendo el tratamiento principal.
RCTs
52Leech therapy for symptomatic treatment of knee osteoarthritis: results and implications of a pilot study
GRADE bajoAndereya S, Stanzel S, Maus U, Mueller-Rath R, Mumme T, Miltner O (2006) · Alternative Therapies in Health and Medicine
Effectiveness of leech therapy in osteoarthritis of the thumb carpometacarpal joint: a randomized controlled trial
GRADE bajoMichalsen A, Lüdtke R, Cesur Ö, Afra D, Musial F, Baecker M, Dobos GJ (2008) · Pain
Leech therapy versus topical diclofenac for thumb carpometacarpal osteoarthritis: a randomized pilot study
GRADE bajoAndereya S, Stanzel S, Maus U, Mueller-Rath R (2008) · Zeitschrift für Orthopädie und Unfallchirurgie
Leech therapy for chronic non-specific low back pain: a randomized controlled trial
GRADE bajoHohmann CD, Stange R, Steckhan N, Robens S, Ostermann T, Paetow A, Michalsen A (2018) · Deutsches Ärzteblatt International
Leech therapy versus compression stockings for symptomatic varicose veins: open-label randomized controlled trial
GRADE bajoKalender ME, Comez G, Sevinc A, Dirier A, Camci C (2014) · Phlebology
Medicinal leech therapy on head and neck patients: a review and case series of finger and digit replantation salvage
GRADE bajoElyassi AR, Terres J, Rowshan HH (2014) · Journal of Oral and Maxillofacial Surgery
Effects of leech therapy on knee osteoarthritis: a randomized clinical trial in an Iranian population
GRADE bajoKhoshnevisan A, Sahebkar A, Mohammadpour AH, Mosaffa-Jahromi M (2022) · Journal of Traditional and Complementary Medicine
Leech therapy in chronic shoulder pain: a randomized pilot study
GRADE bajoMüller IM, Stange R, Heider U, Uehleke B, Cesur Ö, Michalsen A (2010) · Forschende Komplementärmedizin
Leech therapy for postherpetic neuralgia: a single-blind pilot trial
GRADE bajoMueller IM, Stange R, Michalsen A (2012) · Schmerz (Berlin, Germany)
Leech therapy in chronic myofascial temporomandibular disorder: a randomized pilot trial
GRADE bajoCesur Ö, Stange R, Michalsen A, Lüdtke R (2019) · Journal of Oral Rehabilitation
Leech therapy for postoperative pain and swelling after knee arthroscopy: a randomized controlled trial
GRADE bajoBishaw AM, El-Sayed M, Hassan H, Ibrahim M (2020) · Egyptian Rheumatology and Rehabilitation
Effectiveness of leech therapy in chronic lateral epicondylitis: a randomized controlled trial
GRADE bajoBäcker M, Lüdtke R, Afra D, Cesur Ö, Langhorst J, Fink M, Bachmann J, Dobos GJ, Michalsen A (2011) · The Clinical Journal of Pain
Randomised controlled trial with medical leeches for osteoarthritis of the knee
GRADE bajoStange R, Moser C, Hopfenmueller W, Mansmann U, Buehring M, Uehleke B (2012) · Complementary Therapies in Medicine
Medicinal leeches and the microsurgeon: a four-year study, clinical series and risk benefit review
GRADE bajoWhitaker IS, Josty IC, Hawkins S, Azzopardi E, Naderi N, Graf J, Damaris L, Lineaweaver WC, Kon M (2011) · Microsurgery
Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study
GRADE bajoStamenova PK, Marchetti T, Simeonov I (2001) · European Review for Medical and Pharmacological Sciences
Comparisons of medicinal leech therapy with venous catheterization in the treatment of venous congestion of the sural flap
GRADE bajoMozafari N, Ghazisaidi MR, Hosseini SN, Abdolzadeh M (2010) · Microsurgery
Chemical and mechanical alternatives to leech therapy: a systematic review and critical appraisal
GRADE bajoAzzopardi EA, Whitaker IS, Rozen WM, Naderi N, Kon M (2011) · Journal of Reconstructive Microsurgery
Conservative treatment of thumb base osteoarthritis: a systematic review
GRADE bajoSpaans AJ, van Minnen LP, Kon M, Schuurman AH, Schreuders AR, Vermeulen GM (2015) · The Journal of Hand Surgery
Prophylactic versus reactive leech therapy for venous congestion after fingertip replantation: A retrospective comparative study and literature review
GRADE bajoKameda Y, Motomiya M, Watanabe N, Ota M, Iwasaki N (2025) · JPRAS Open
Standardized protocol for artery-only fingertip replantation
GRADE bajoBuntic RF, Brooks D (2010) · The Journal of Hand Surgery
Determining the appropriate number and duration of leech therapy in congested tissues using tissue spectrophotometry and laser Doppler flowmetry
GRADE bajoRothenberger J, Petersen W, Schaller HE, Held M (2016) · Wound Repair and Regeneration
Comparison of the effectiveness of medicinal leech and TENS therapy in the treatment of primary osteoarthritis of the knee: a randomized controlled trial
GRADE bajoIsik M, Ugur M, Yakisan RS, Sari T, Yilmaz N (2017) · Zeitschrift für Rheumatologie
Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial
GRADE bajoAbtahi-Forooshani MS, Roozbehani S, Fatemi M, Noori A (2026) · Health Science Reports
Antimicrobial prophylaxis during Hirudo medicinalis therapy: a multicenter study
GRADE bajoKruer RM, Barton CA, Roberti G, Gilbert B, McMillian WD (2014) · Journal of Reconstructive Microsurgery
Management of complications and compromised free flaps following major head and neck surgery
GRADE bajoKucur C, Durmus K, Uysal IO, Old M, Agrawal A, Arshad H, Teknos TN, Ozer E (2015) · European Archives of Oto-Rhino-Laryngology
Current concepts in salvage procedures for failing microvascular flaps: is there a superior technique? Insights from a systematic review of the literature
GRADE bajoTroeltzsch M, Troeltzsch M, Probst FA, Ristow O, Ehrenfeld M, Otto S (2016) · International Journal of Oral and Maxillofacial Surgery
The Use of Medicinal Leeches for the Treatment of Venous Congestion in Replanted or Revascularized Digits
GRADE bajoArami A, Gurevitz S, Palti R, Menachem S, Berelowitz M, Yaffe B (2018) · Journal of Hand Surgery (American Volume)
The efficacy of arterial only microsurgical nasal replantation: a systematic review
GRADE bajoSecanho MS, Rajaram R, de Menezes Neto BF, Cavale N, Ng SK, Neto AAP (2024) · ANZ Journal of Surgery
Microbiota Dynamics: A Key Factor in Hirudotherapy-Related Infections?
GRADE bajoKarasartova D, Arslan-Akveran G, Sensoz S, Mumcuoglu KY, Taylan-Ozkan A (2025) · Microorganisms
Effects of hirudotherapy on liver functions, lipid profile, and insulin sensitivity in rats with metabolic syndrome
GRADE bajoBilden A, Kocak S, Yildiz HT, Cakir F, Kahraman M, Cicek M (2026) · BMC Complementary Medicine and Therapies
Investigation of the therapeutic effects of medicinal leech treatment on lower extremity ischemia-reperfusion injury
GRADE bajoUnal K, Samur B, Sharif A, Ibrahimkhanli L, Yumusak N (2026) · Journal of Complementary & Integrative Medicine
Leeches and hand surgery: history, physiology, and a scoping review
GRADE bajoChabridon AI, Coquerel-Beghin D, Leger M, Baamir A, Bazeli A, Auquit-Auckbur I (2026) · Hand Surgery and Rehabilitation
Analysis of antibiotic resistant infections associated with hirudotherapy
GRADE bajoBrauer PR, Saadah M, Fritz MA, Wu SS, Lamarre ED (2024) · American Journal of Otolaryngology
Applications of leech therapy in medicine: a systematic review
GRADE bajoHosseini M, Jadidi A, Derakhshan Barjoei MM, Salehi M (2024) · Frontiers in Medicine
The Use of Medicinal Leeching in Breast Surgery: A Systematic Review
GRADE bajoRajaram R, Cevik J, Bhindi N, Seth I, Rozen WM (2024) · Journal of Clinical Medicine
A Systematic Review of Complementary and Alternative Veterinary Medicine: Miscellaneous Therapies
GRADE bajoBergh A, Lund I, Boström A, Hyytiäinen H, Asplund K (2021) · Animals
Impact of Bivalirudin on Ischemia/Reperfusion Injury in Patients with Reperfused STEMI Assessed by Cardiac Magnetic Resonance
GRADE bajoZhang Y, Zou Z, Xu B, Chen B, Ge H, Ding S, Pu J (2024) · Pharmaceuticals
Safety of Bivalirudin Combined with Ticagrelor in the Emergency PCI in Patients with Acute ST-Segment Elevation Myocardial Infarction
GRADE bajoWang ZD, Chen YX, Liu M, Li P, Liang XW, Zhu XZ, Xie WC, Liao W (2022) · Clinical and Applied Thrombosis/Hemostasis
Effect of Perioperative Antithrombotics on Head and Neck Microvascular Free Flap Survival After Anastomotic Revision
GRADE bajoBishop JL, Vasudev M, Garcia N, Heslop G, Pham TT, Hicks MD, Chowdhury F, Grayson JW, Goddard JA, Tjoa T, Haidar Y, Thomas CM (2023) · Otolaryngology — Head and Neck Surgery (American Academy of Otolaryngology)
Prospective Randomized Pilot Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric Extracorporeal Membrane Oxygenation
GRADE bajoMcMichael A, Weller J, Li X, Hatton L, Zia A, Raman L (2024) · Pediatric Critical Care Medicine
Efficacy of Bivalirudin for Therapeutic Anticoagulation in COVID-19 Patients Requiring ECMO Support
GRADE bajoTrigonis R, Smith N, Porter S, Anderson E, Jennings M, Kapoor R, Hage C, Moiz S, Garcia J, Rahman O (2021) · Journal of Cardiothoracic and Vascular Anesthesia
Bivalirudin versus heparin anticoagulation in patients receiving extracorporeal membrane oxygenation
GRADE bajoHuang D, Guan Q, Qin J, Shan R, Wu J, Zhang C (2022) · Perfusion
Heparin-based versus bivalirudin-based anticoagulation in pediatric extracorporeal membrane oxygenation: A systematic review
GRADE bajoValdes CA, Sharaf OM, Bleiweis MS, Jacobs JP, Mumtaz M, Sharaf RM, Jeng EI, Peek GJ (2023) · Frontiers in Medicine
Comparison of Bivalirudin Versus Heparin for Anticoagulation During Extracorporeal Membrane Oxygenation
GRADE bajoHasegawa D, Sato R, Prasitlumkum N, Nishida K, Keaton B, Acquah SO, Im Lee Y (2022) · ASAIO Journal
Heparin Versus Bivalirudin for Anticoagulation in Adult Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis
GRADE bajoWieruszewski PM, Macielak SA, Nei SD, Moman RN, Seelhammer TG, Nabzdyk CGS, Gerberi DJ, Mara KC, Hooten WM, Wittwer ED (2022) · ASAIO Journal
Bivalirudin or heparin for systemic anticoagulation during pediatric extracorporeal membrane oxygenation: Multicenter retrospective study
GRADE bajoHamzah M, Seelhammer TG, Beshish AG, Byrnes J, Yabrodi M, Szadkowski A, Lutfi R, Andrijasevic N, Hock K, Worley S, Macrae DJ (2023) · Thrombosis Research
Is bivalirudin an alternative anticoagulant for extracorporeal membrane oxygenation (ECMO) patients? A systematic review and meta-analysis
GRADE bajoLi DH, Sun MW, Zhang JC, Zhang C, Deng L, Jiang H (2021) · Thrombosis Research
Bivalirudin Monitoring in Pediatric Ventricular Assist Device and Extracorporeal Membrane Oxygenation: Analysis of Single-Center Retrospective Cohort Data 2018-2022
GRADE bajoEngel ER, Perry T, Block M, Palumbo JS, Lorts A, Luchtman-Jones L (2024) · Pediatric Critical Care Medicine
Improved outcomes with pulsatile paracorporeal ventricular assist device support in children: A single-center experience
GRADE bajoIaprintsev V, Fricke TA, Buratto E, Zubritskiy A, Perrier S, Eastaugh L, Barnes C, Sheridan B, Naimo PS, Brizard CP, Mathew J, Konstantinov IE (2025) · JTCVS Open
Burden of illness of non-hematopoietic stem cell transplant-related hepatic sinusoidal obstruction syndrome: A systematic review
GRADE bajoFan L, Stewart F, Ruiz K, Devani D, Fusco N, Gill M, Amber V, Su W, Gangi A, Hanvesakul R (2024) · Heliyon
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