Effect of taleeq (leech therapy) in dawali (varicose veins)
Nigar Z, Alam MA (2011) · Ancient Science of Life · n=50
Perfil del estudio
- Diseño
- single-center, open-label, randomized controlled clinical trial (National Institute of Unani Medicine Hospital, Bangalore, India)
- Tamaño de la muestra (n)
- 50
- Intervención
- Leech therapy (taleeq) applied on alternate days for 2 months (test group, n=30)
- Comparador
- Grade 2 compression stockings plus limb elevation for 2 months (control group, n=20)
- Punto final primario
- Composite of pain/leg discomfort, limb girth at calf/ankle/feet, pigmentation area and colour, assessed every 15 days; hemoglobin monitoring for anaemia; venous anatomy by colour-flow Doppler
- Resultado primario
- Test group: significant reduction in pain, limb girth, pigmentation, and number of perforators (within-group p-values significant); control group: significant reduction in pain and limb girth only with no pigmentation improvement; neither group showed significant change in saphenofemoral or saphenopopliteal junction incompetency
- Duración del seguimiento
- 60 days
- PMID
- 22557433
Hallazgos clave
- First randomized clinical trial of leech therapy (taleeq) for varicose veins (dawali) in the Unani medicine tradition
- Multi-endpoint improvement in pain, limb girth, pigmentation, and perforator count favored leech arm over compression stockings
- Neither modality altered underlying saphenofemoral or saphenopopliteal junction incompetency - effect is symptomatic only
- Authors recommended leech therapy be combined with compression and lifestyle modification for optimal varicose vein management
- Conducted within a Unani regimental therapy framework with conceptual basis in humoural theory (saudavi madda, balgham ghaleez)
Limitaciones
- Unequal group sizes (n=30 test vs n=20 control) raise selection-bias risk
- Open-label design with unblinded outcome assessment
- Composite endpoints not statistically pre-specified or hierarchically tested
- Single Indian Unani institution - generalizability to Western venous-disease populations untested
- No quantitative reflux velocity, venous filling index, or CEAP classification reported
Implicaciones clínicas
Nigar 2011 is the most-cited Indian Unani RCT on leech therapy for chronic venous insufficiency. Its primary value is documentation of a symptom-based regimental therapy framework that integrates leeching with compression and lifestyle modification. The trial does not support leech therapy as a primary treatment for advanced venous disease (no effect on junction incompetency) but does support symptomatic-relief use in patients seeking traditional-medicine approaches. For Western clinicians, Nigar 2011 illustrates how leech therapy is positioned within the wider Unani treatment philosophy rather than as a standalone intervention, and should be interpreted in that conceptual context.
Estudios relacionados
Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study
Stamenova PK, Marchetti T, Simeonov I (2001)
Hirulog in the treatment of unstable angina. Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial
Fuchs J, Cannon CP (1995)
Medicinal leech therapy in venous congestion and various ulcer forms: Perspectives of Western, Persian and Indian medicine
Koeppen D, Aurich M, Pasalar M, Rampp T (2020)