Biblioteca de investigación
Revisiones curadas de investigación revisada por pares relevante para hirudoterapia
ASH structured research registries
In addition to 10059+ long-form research articles below, ASH curates 5 structured registries with cross-linking:
Editorial transparency & research roadmap
ASH treats this library as a living dataset. Current import baseline: 10059 long-form articles plus 449 metadata-imported PubMed/DOI records, with a public 10,000-article ingestion target. The pages below explain how we grade evidence, what PMIDs are still unverified, and where the corpus is going next.
Última actualización: March 18, 2026
La ASH Research Library indexa actualmente 1.400+ publicaciones revisadas por pares relevantes para la hirudoterapia, abarcando ensayos clínicos, microcirugía, genómica y proteómica, desarrollo de fármacos, farmacología salival, y seguridad y control de infecciones. Cada artículo lleva una cita completa y un enlace a la fuente primaria cuando es posible. Un subconjunto curado (50+ entradas) está totalmente anotado en Hirudopedia por condición, grado de evidencia y diseño de estudio.
Disciplina de evidencia
Categorías de investigación
Resistencia antimicrobiana
Péptidos antimicrobianos, sinergia con antibióticos y nuevos enfoques contra patógenos resistentes.
248 artículos
Farmacología salival
Compuestos bioactivos en la saliva de sanguijuela — descubrimiento, caracterización y potencial terapéutico.
968 artículos
Desarrollo de fármacos
Traducción de compuestos derivados de sanguijuelas del laboratorio a la práctica clínica.
3264 artículos
Ensayos clínicos
Ensayos controlados aleatorizados y revisiones sistemáticas de los resultados de la hirudoterapia.
6472 artículos
Seguridad y control de infecciones
Vigilancia de Aeromonas, protocolos de profilaxis y datos de eventos adversos.
1000 artículos
Genómica y proteómica
Descubrimiento basado en ómicas de nuevas proteínas salivales de sanguijuelas y sus funciones.
808 artículos
Todos los artículos
Showing the 24 most recently added articles. Search or browse all 10,059 articles in the Smart Library (faceted search by topic, evidence grade, year, and verification status), or by category above.
Function of the waterfowl nests as reproduction and living areas for leeches (Annelida: Hirudinea)
Genómica y proteómicaCeylan et al. (2021) — Animal reproduction science
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Correction to: Bacterial Community of the Digestive Tract of the European Medicinal Leech (Hirudo verbana) from the Danube River
Seguridad y control de infeccionesNeupane et al. (2019) — Microbial ecology
Peer-reviewed safety and infection-control research relevant to leech therapy and microsurgical wound management. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Draft Genome Sequence of Pedobacter sp. Strain Hv1, an Isolate from Medicinal Leech Mucosal Castings
Genómica y proteómicaOtt et al. (2015) — Genome announcements
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Effect of medicinal leeches' antigens on the proliferative response of human blood mononuclear cells and cytokine production in vitro
Ensayos clínicosFrolov et al. (2015) — Annals of parasitology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Complete Genome Sequence of the Novel Leech Symbiont Mucinivorans hirudinis M3T
Genómica y proteómicaNelson et al. (2015) — Genome announcements
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Spatial and temporal population dynamics of a naturally occurring two-species microbial community inside the digestive tract of the medicinal leech
Genómica y proteómicaKikuchi et al. (2007) — Applied and environmental microbiology
Peer-reviewed genomics, proteomics, and molecular research relevant to leech biology and salivary compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Venous engorged tissue flaps treated with medicinal leeches
Ensayos clínicosRodgers et al. (1992) — Ophthalmic plastic and reconstructive surgery
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Leech therapy in the management of acute venous congestion of an infant's lower limb
Ensayos clínicosWeinfeld et al. (1998) — Plastic and reconstructive surgery
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Bivalirudin for unsalvageable venous congestion or obstruction in head and neck free flap reconstruction
Desarrollo de fármacosHarris et al. (2024) — Oral oncology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Recombinant hirudin and PAR-1 regulate macrophage polarisation status in diffuse large B-cell lymphoma
Desarrollo de fármacosPei et al. (2024) — BMC biotechnology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Comment on: Bivalirudin during thrombolysis with catheter-directed tPA in a heparin-refractory patient: A case report
Desarrollo de fármacosHan (2024) — Pediatric blood & cancer
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Bivalirudin: The misunderstood alternative to heparin
Desarrollo de fármacosFaraoni et al. (2024) — Paediatric anaesthesia
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Unresponsiveness of Activated Partial Thromboplastin Time to Bivalirudin in Adults Receiving Extracorporeal Membrane Oxygenation
Desarrollo de fármacosJatis et al. (2024) — ASAIO journal (American Society for Artificial Internal Organs : 1992)
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Protein-Engineered Hirudins with Enhanced Anticoagulant Activities Developed by a Molecular Integrative Approach
Ensayos clínicosSun et al. (2024) — Journal of medicinal chemistry
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Use of bivalirudin after initial heparin management among adult patients on long-term venovenous extracorporeal support as a bridge to lung transplant: A case series
Desarrollo de fármacosHalawi et al. (2024) — Pharmacotherapy
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Bivalirudin Stability in Citrated Plasma and Citrated Whole Blood
Desarrollo de fármacosBruzdoski et al. (2024) — Archives of pathology & laboratory medicine
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Comparison of bleeding and thrombotic outcomes in veno-venous extracorporeal membrane oxygenation: Heparin versus bivalirudin
Desarrollo de fármacosKartika et al. (2024) — European journal of haematology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Management of Bivalirudin Dosing and Replacement Fluid During Therapeutic Plasma Exchange in Children on Extracorporeal Membrane Oxygenation
Desarrollo de fármacosChomat et al. (2024) — ASAIO journal (American Society for Artificial Internal Organs : 1992)
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Editorial: Bivalirudin versus unfractionated heparin in acute myocardial infarction: Why are we still debating?
Desarrollo de fármacosCohen et al. (2024) — Cardiovascular revascularization medicine : including molecular interventions
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
One-year clinical outcomes of bivalirudin versus unfractionated heparin in patients with type 2 diabetes undergoing elective percutaneous coronary intervention
Desarrollo de fármacosLi et al. (2023) — Diabetes & metabolic syndrome
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Editorial: Bivalirudin with post-procedural infusion: Should the Guidelines change to keep up with the data?
Desarrollo de fármacosLipinski (2023) — Cardiovascular revascularization medicine : including molecular interventions
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
The effect of bivalirudin on coagulation function in male patients with coronary heart disease undergoing percutaneous coronary intervention
Desarrollo de fármacosDequan et al. (2023) — Pakistan journal of pharmaceutical sciences
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Anticoagulation strategies in patients with extracorporeal membrane oxygenation: A network meta-analysis and systematic review
Ensayos clínicosChen et al. (2023) — Pharmacotherapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Anticoagulation Management in Temporary Mechanical Circulatory Support Devices
Ensayos clínicosYin (2023) — Texas Heart Institute journal
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
Leer análisis →
Sugiera un artículo para revisión
¿Conoce una publicación significativa relevante para la hirudoterapia? Agradecemos sugerencias para nuestra biblioteca de investigación.
Contáctenos →