Biblioteca de investigación
Revisiones curadas de investigación revisada por pares relevante para hirudoterapia
ASH structured research registries
In addition to 10051+ long-form research articles below, ASH curates 5 structured registries with cross-linking:
Editorial transparency & research roadmap
ASH treats this library as a living dataset. Current import baseline: 10051 long-form articles plus 449 metadata-imported PubMed/DOI records, with a public 10,000-article ingestion target. The pages below explain how we grade evidence, what PMIDs are still unverified, and where the corpus is going next.
Última actualización: June 18, 2026
La ASH Research Library indexa actualmente 1.400+ publicaciones revisadas por pares relevantes para la hirudoterapia, abarcando ensayos clínicos, microcirugía, genómica y proteómica, desarrollo de fármacos, farmacología salival, y seguridad y control de infecciones. Cada artículo lleva una cita completa y un enlace a la fuente primaria cuando es posible. Un subconjunto curado (50+ entradas) está totalmente anotado en Hirudopedia por condición, grado de evidencia y diseño de estudio.
Disciplina de evidencia
Categorías de investigación
Resistencia antimicrobiana
Péptidos antimicrobianos, sinergia con antibióticos y nuevos enfoques contra patógenos resistentes.
248 artículos
Farmacología salival
Compuestos bioactivos en la saliva de sanguijuela — descubrimiento, caracterización y potencial terapéutico.
967 artículos
Desarrollo de fármacos
Traducción de compuestos derivados de sanguijuelas del laboratorio a la práctica clínica.
3263 artículos
Ensayos clínicos
Ensayos controlados aleatorizados y revisiones sistemáticas de los resultados de la hirudoterapia.
6465 artículos
Seguridad y control de infecciones
Vigilancia de Aeromonas, protocolos de profilaxis y datos de eventos adversos.
994 artículos
Genómica y proteómica
Descubrimiento basado en ómicas de nuevas proteínas salivales de sanguijuelas y sus funciones.
807 artículos
Todos los artículos
Recent research articles carrying original, peer-reviewed ASH analysis. See the full index of all 2,460 analysed articles, or search the complete 10,051-article corpus in the Smart Library (faceted by topic, evidence grade, year, and verification status).
Comparison of bleeding and thrombotic outcomes in veno-venous extracorporeal membrane oxygenation: Heparin versus bivalirudin
Desarrollo de fármacosKartika et al. (2024) — European journal of haematology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices
Desarrollo de fármacosPappalardo et al. (2012) — Minerva anestesiologica
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Heparin-induced thrombosis with a normal platelet count
Ensayos clínicosAlvarez et al. (2007) — Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Effects of Bivalirudin and Unfractionated Heparin on Liver and Renal Function in Chinese Patients with Coronary Artery Disease Undergoing Coronary Angiography with/without Percutaneous Coronary Intervention
Desarrollo de fármacosJia et al. (2021) — Journal of clinical and translational hepatology
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Association Between Argatroban and Outcomes of Branch Atheromatous Disease: A Propensity-Matched Analysis From MRI-Based Study
Desarrollo de fármacosLi et al. (2025) — CNS neuroscience & therapeutics
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Safety and efficacy of argatroban combined with antiplatelet therapy for acute mild-to-moderate ischemic stroke with large artery atherosclerosis
Desarrollo de fármacosYan et al. (2025) — Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Delayed-onset eptifibatide-induced thrombocytopenia
Ensayos clínicosHuffman et al. (2024) — American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Clinical impact of kidney function in patients with atrial fibrillation receiving oral anticoagulants
Ensayos clínicosMatsuoka et al. (2025) — International journal of cardiology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Renal outcomes following oral anticoagulation in non-valvular atrial fibrillation: A multicentre, propensity-matched retrospective analysis in an Asian population
Ensayos clínicosKoh et al. (2025) — Asian cardiovascular & thoracic annals
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Effectiveness and Safety in Patients with Non-Valvular Atrial Fibrillation Who Switched from Warfarin to Direct Oral Anticoagulants in Medicare Population
Ensayos clínicosAtreja et al. (2025) — Advances in therapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Population pharmacokinetics of unfractionated heparin and multivariable analysis of activated clotting time in patients undergoing radiofrequency ablation of atrial fibrillation
Desarrollo de fármacosKonecki et al. (2024) — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Bleeding Associated With Antiarrhythmic Drugs in Patients With Atrial Fibrillation Using Direct Oral Anticoagulants: A Nationwide Population Cohort Study
Ensayos clínicosWu et al. (2024) — Journal of the American Heart Association
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Comparing Efficacy and Safety of Different Anticoagulants in Cerebral Venous Thrombosis: A Systematic Review and Network Meta-Analysis
Ensayos clínicosWaseem et al. (2026) — Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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PROS1 (Cys228Tyr) missense mutation associated with mesenteric and pulmonary venous thromboembolism during the COVID-19 pandemic: a case report
Ensayos clínicosHuang et al. (2025) — Frontiers in cardiovascular medicine
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Comparison of VTE prophylaxis agents on hemoglobin levels after total knee arthroplasty: a hospital information system-based observational study
Seguridad y control de infeccionesYuan et al. (2025) — Journal of orthopaedic surgery and research
Peer-reviewed safety and infection-control research relevant to leech therapy and microsurgical wound management. Indexed in PubMed and verified against the NCBI record.
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Upper Extremity Deep Vein Thrombosis Secondary to Gastric Cancer: A Case Report
Ensayos clínicosTakano et al. (2026) — Cureus
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Treatment of cancer-associated thrombosis: The evolution of anticoagulant choice and clinical insights into practical management
Ensayos clínicosRiess et al. (2021) — Critical reviews in oncology/hematology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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An update on the efficacy and safety of novel anticoagulants for cancer associated thrombosis
Ensayos clínicosCosmi (2021) — Expert opinion on pharmacotherapy
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Efficacy and safety of Xa inhibitors for the treatment of cancer-associated venous thromboembolism
Desarrollo de fármacosKimpton et al. (2019) — Expert opinion on drug safety
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Peak and Trough Concentration Ranges of Factor Xa Inhibitors for Preventing Thromboembolic Stroke in Korean Patients with Non-valvular Atrial Fibrillation
Desarrollo de fármacosPark et al. (2026) — Annals of laboratory medicine
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Real-world evidence comparing oral anticoagulants for NVAF in Europe: a systematic review and network meta-analysis
Ensayos clínicosCichewicz et al. (2025) — Future cardiology
Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.
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Edoxaban-Induced Vanishing Bile Duct Syndrome: A Case Report With Review of the Literature
Desarrollo de fármacosBorgonovo et al. (2024) — Cureus
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Optimizing warfarin dosing for patients with atrial fibrillation using machine learning
Desarrollo de fármacosPetch et al. (2024) — Scientific reports
Peer-reviewed pharmacology and drug-development research relevant to anticoagulants and leech-derived compounds. Indexed in PubMed and verified against the NCBI record.
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Leech-borne Serratia marcescens infection following complex hand injury.
Seguridad y control de infeccionesPereira et al. (1998) — British journal of plastic surgery
Leeches are commonly used in the postoperative course of plastic surgical operations where there is venous congestion in a pedicled or free flap. They provide a temporary relief to venous engorgement whilst venous drainage is re-established.
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