Knowledge Coverage Map
What ASH covers — and what remains open — across organ systems and evidence tiers.
ASH organizes its clinical knowledge into structured registries. This page is a live map: as new conditions, compounds, and trials are added, the counts and category distribution update automatically. There are no hand-maintained numbers.
Live registry counts
Auto-pulled from lib/*-registry.ts at render time.
199
Conditions
FDA-cleared, off-label & investigational — Tier A/B/C
201
Compounds
Salivary pharmacology: hirudin, eglins, destabilase, more
169
RCTs
GRADE-rated trials, PMIDs verified against PubMed
68
Biographies
Investigators across antiquity through modern molecular biology
155
Jurisdictions
Global regulatory survey — honest 'unregulated' markers
10,030
Research articles
PMID-verified library — target 10,000 (long-term roadmap)
100% of 10,000
Conditions by evidence tier
199 total conditions across three tiers. Honest framing: most off-label uses are Tier C investigational.
FDA-cleared
K040187: venous congestion in surgical flaps. The only formally FDA-cleared use of medicinal leech therapy.
Off-label with RCT support
Off-label uses with at least one RCT or systematic review. Common candidates: knee OA, chronic venous insufficiency, certain dermatology.
- Knee Osteoarthritis
- Thumb Carpometacarpal (CMC-1) Osteoarthritis
- Lateral Epicondylitis (Tennis Elbow)
- Plantar Fasciitis
- Chronic Venous Insufficiency (CEAP C3-C5)
+ 5 more
Investigational
Mechanistic rationale, case series, small pilots. Includes many conditions that mainstream medicine has not researched.
- Migraine
- Tension-Type Headache
- Essential Hypertension (Adjunctive)
- Varicose Veins (Symptomatic Tributaries)
- Hemorrhoids (Grade II-III, Symptomatic)
+ 181 more
Coverage by organ system
Cross-walk to clinical-specialties pages. Numbers reflect the conditions registry.
Surgical Reconstruction
3Tier A: 3 · Tier B: 0 · Tier C: 0
Vascular
19Tier A: 0 · Tier B: 3 · Tier C: 16
- Chronic Venous Insufficiency (CEAP C3-C5)
- Venous Leg Ulcer
- Post-Thrombotic Syndrome
- Varicose Veins (Symptomatic Tributaries)
+ 15 more in this category
Musculoskeletal
35Tier A: 0 · Tier B: 4 · Tier C: 31
- Knee Osteoarthritis
- Thumb Carpometacarpal (CMC-1) Osteoarthritis
- Lateral Epicondylitis (Tennis Elbow)
- Plantar Fasciitis
+ 31 more in this category
Dermatological
41Tier A: 0 · Tier B: 0 · Tier C: 41
+ 37 more in this category
Neurological
37Tier A: 0 · Tier B: 2 · Tier C: 35
+ 33 more in this category
Cardiovascular
4Tier A: 0 · Tier B: 0 · Tier C: 4
Ophthalmologic
3Tier A: 0 · Tier B: 0 · Tier C: 3
ENT
17Tier A: 0 · Tier B: 1 · Tier C: 16
- Chronic Rhinosinusitis
- Subjective Tinnitus
- Ménière's Disease (Adjunctive)
- Pulsatile Tinnitus (Vascular-Origin Subtype)
+ 13 more in this category
Gastrointestinal
10Tier A: 0 · Tier B: 0 · Tier C: 10
- Hemorrhoids (Grade II-III, Symptomatic)
- External Thrombosed Hemorrhoid (Acute, <72h)
- Chronic Anal Fissure (>8 Weeks)
- Non-Alcoholic Fatty Liver Disease (Investigational Adjunct)
+ 6 more in this category
Urogenital
11Tier A: 0 · Tier B: 0 · Tier C: 11
- Peyronie's Disease (Stable Phase)
- Chronic Prostatitis / Chronic Pelvic Pain Syndrome (CP/CPPS)
- Chronic Prostatitis / Chronic Pelvic Pain Syndrome (Extended Protocol)
- Interstitial Cystitis / Bladder Pain Syndrome (Investigational)
+ 7 more in this category
Gynecologic
12Tier A: 0 · Tier B: 0 · Tier C: 12
- Lactational Mastitis (Non-Suppurative)
- Endometriosis-Related Pelvic Pain
- Primary Dysmenorrhea
- Chronic Pelvic Pain Syndrome (Non-Specific)
+ 8 more in this category
Other
7Tier A: 0 · Tier B: 0 · Tier C: 7
- Metabolic Syndrome (Investigational Adjunct)
- Hashimoto's Thyroiditis (Investigational Cervical Adjunct)
- Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (Investigational Adjunct)
- Stage III Postsurgical Lymphedema (Highly Investigational Adjunct)
+ 3 more in this category
What's still open
The 10,000-article target means current coverage is the foundation, not the destination. Major gaps actively being prioritized:
- Translational pipeline depth: Each compound entry needs detailed drug-development trajectory (preclinical → FDA pathway → clinical context).
- Pediatric protocols: Limited registry coverage; weight-based dosing absent in current literature.
- Geographic regulatory survey: Many African, Oceanian, and Caribbean jurisdictions remain "unregulated" — honest marker, but needs ground-truth verification.
- Recent RCT digestion (2024-2026): Continuous PubMed surveillance for new trials in OA, microsurgery, integrative pain medicine.
- Translation parity: RU/ES/DE locales need ongoing medical-grade editorial pass across all 36 namespaces.
Researchers and clinicians can contribute via the Contact & Transparency page.