Biomimetic platelet nanomotors for site-specific thrombolysis and ischemic injury alleviation
Nanomedicine study published in ACS Applied Materials & Interfaces (2023)
Abstract
Due to the mortality associated with thrombosis and its high recurrence rate, there is a need to investigate antithrombotic approaches. Noninvasive site-specific thrombolysis is a current approach being used; however, its usage is characterized by the following limitations: low targeting efficiency, poor ability to penetrate clots, rapid half-life, lack of vascular restoration mechanisms, and risk of thrombus recurrence that is comparable to that of traditional pharmacological thrombolysis agents. Therefore, it is vital to develop an alternative technique that can overcome the aforementioned limitations. To this end, a cotton-ball-shaped platelet (PLT)-mimetic self-assembly framework engineered with a phototherapeutic poly(3,4-ethylenedioxythiophene) (PEDOT) platform has been developed. This platform is capable of delivering a synthetic peptide derived from hirudin P6 (P6) to thrombus lesions, forming P6@PEDOT@PLT nanomotors for noninvasive site-specific thrombolysis, effective anticoagulation, and vascular restoration. Regulated by P-selectin mediation, the P6@PEDOT@PLT nanomotors target the thrombus site and subsequently rupture under near-infrared (NIR) irradiation, achieving desirable sequential drug delivery. Furthermore, the movement ability of the P6@PEDOT@PLT nanomotors under NIR irradiation enables effective penetration deep into thrombus lesions, enhancing bioavailability. Biodistribution analyses have shown that the administered P6@PEDOT@PLT nanomotors exhibit extended circulation time and metabolic capabilities. In addition, the photothermal therapy/photoelectric therapy combination can significantly augment the effectiveness (ca. 72%) of thrombolysis. Consequently, the precisely delivered drug and the resultant phototherapeutic-driven heat-shock protein, immunomodulatory, anti-inflammatory, and inhibitory plasminogen activator inhibitor-1 (PAI-1) activities can restore vessels and effectively prevent rethrombosis. The described biomimetic P6@PEDOT@PLT nanomotors represent a promising option for improving the efficacy of antithrombotic therapy in thrombus-related illnesses.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Platelet-membrane-coated nanomotors loaded with hirudin variant 2 demonstrating site-specific thrombolysis at clot site and ischemic injury alleviation in murine stroke models.
Por qué esto importa para la hirudoterapia
Este estudio describe el desarrollo de nanomotores P6@PEDOT@PLT, autoensamblajes biomiméticos de tipo plaquetario que vehiculizan un péptido sintético derivado de la hirudina P6 combinado con una plataforma fototerapéutica PEDOT, para la trombólisis dirigida al sitio, la anticoagulación y la restauración vascular. Los nanomotores se dirigen a los sitios de trombo mediante la mediación de la P-selectina, se rompen bajo irradiación en el infrarrojo cercano para liberar el fármaco de forma secuencial, y su desplazamiento permite una penetración más profunda del coágulo, logrando una eficacia de trombólisis de aproximadamente el 72 %, al tiempo que proporcionan efectos antiinflamatorios y antirretrombóticos. El trabajo es relevante para el ámbito de ASH porque reutiliza un péptido anticoagulante derivado de la hirudina dentro de un sistema novedoso de administración nanoterapéutica. Advertencia: en el resumen no se especifican el tipo de estudio ni los detalles del modelo in vivo más allá de la biodistribución, y la relevancia para la hirudoterapia viva o el secretoma intacto de la sanguijuela es indirecta, al estar centrada en un fragmento sintético de hirudina.
Citación
Biomimetic platelet nanomotors for site-specific thrombolysis and ischemic injury alleviation.
Chen YT et al. · ACS applied materials & interfaces, 2023
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026