BRIGHT-4 Trial — Bivalirudin vs Heparin by BMI

Post-hoc analysis of the BRIGHT-4 randomized trial examining bivalirudin (a synthetic analog of leech-derived hirudin) versus heparin in patients with acute myocardial infarction, stratified by body mass index. Demonstrated consistent benefit of bivalirudin across BMI categories.

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More peer-reviewed studies in Arzneimittelentwicklung.

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• Novel CRA Protein from Hirudo medicinalis — Complement Regulation — Research team (2025) (2025)
• Hirunipin-2 — Second-Generation Leech Antimicrobial Peptide — Kumar et al. (2025)
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• Hirudotherapy in Medicine and Dentistry — Jha K et al. (2015)
• Medicinal leech therapy (hirudotherapy): a brief overview — Singh A (2010)
• HIRUDOTHERAPY IN PRESBYACUZIS PRAECOX IN CLEAN-UP WORKERS AFTER THE CHORNOBYL ACCIDENT DURING THE POST-CATASTROPHE YEARS — Zabolotnyi D, Mishchanchuk N (2019)