Nitric oxide in the ECMO circuit as a treatment option for heparin-induced thrombocytopenia: A case report

IntroductionExtracorporeal membrane oxygenation (ECMO) involves the use of a synthetic circuit, which initiates a complex interplay of inflammatory and pro-coagulant responses. This intricate, self-reinforcing process results in a prothrombotic state, predisposing patients to arterial, venous, or oxygenator thrombosis. Unfractionated heparin is the standard anticoagulant chosen in ECMO patients to prevent such complications.Case ReportIn this case report our patient presented heparin-induced thrombocytopenia (HIT), a possible complication.DiscussionAlternative strategies such as bivalirudin and argatroban are possible options but due the unavailability of those medications at our institution, nitric oxide (NO) via sweep-gas flow was deemed a reasonable alternative considering it's anti-aggregant effect.ConclusionThis case report details the use of NO as a possible alternative anticoagulant strategy in a patient with ECMO complicated by HIT.

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Reports use of sweep-gas nitric oxide as an unconventional anti-aggregant alternative on the ECMO circuit when bivalirudin and argatroban were unavailable to manage HIT during ECMO.

Leech-derived molecules this paper discusses, each with a full profile in the ASH compound registry:

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