Utility of Routine Laboratory Biomarkers to Detect COVID-19: A Systematic Review and Meta-Analysis
Meta-analysis published in Viruses (2021)
Abstract
No routine laboratory biomarkers perform well enough in diagnosing COVID-19 in isolation for them to be used as a standalone diagnostic test or to help clinicians prioritize patients for treatment. Instead, other diagnostic tests are needed. The aim of this work was to statistically summarise routine laboratory biomarker measurements in COVID-19-positive and -negative patients to inform future work. A systematic literature review and meta-analysis were performed. The search included names of commonly used, routine laboratory tests in the UK NHS, and focused on research papers reporting laboratory results of patients diagnosed with COVID-19. A random effects meta-analysis of the standardized mean difference between COVID-19-positive and -negative groups was conducted for each biomarker. When comparing reported laboratory biomarker results, we identified decreased white blood cell, neutrophil, lymphocyte, eosinophil, and platelet counts; while lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase were elevated in COVID-19-positive compared to COVID-19-negative patients. Differences were identified across a number of routine laboratory biomarkers between COVID-19-positive and -negative patients. Further research is required to identify whether routine laboratory biomarkers can be used in the development of a clinical scoring system to aid with triage of patients.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Zusammenfassung
No routine laboratory biomarkers perform well enough in diagnosing COVID-19 in isolation for them to be used as a standalone diagnostic test or to help clinicians prioritize patients for treatment.
Warum dies für die Hirudotherapie relevant ist
Diese systematische Übersichtsarbeit und Metaanalyse evaluierte routinemäßige Laborbiomarker zur Unterscheidung von COVID-19-positiven und COVID-19-negativen Patienten und analysierte standardisierte Mittelwertdifferenzen über mehrere häufige, im britischen NHS verwendete Blutuntersuchungen hinweg. Die Studie ergab, dass COVID-19-positive Patienten im Vergleich zu negativen Patienten verringerte Leukozyten-, Neutrophilen-, Lymphozyten-, Eosinophilen- und Thrombozytenzahlen sowie erhöhte Werte für Laktatdehydrogenase, Aspartat-Aminotransferase und Alanin-Aminotransferase aufwiesen. Diese Studie hat keine Relevanz für die Hirudotherapie, das Blutegelsekretom oder aus Blutegeln gewonnene Therapeutika. Sie betrifft die Leistung diagnostischer Biomarker bei Infektionskrankheiten und behandelt keine blutegelbezogene Intervention, keinen Antikoagulationsmechanismus und keine Wundheilungsanwendung.
Zitation
Utility of Routine Laboratory Biomarkers to Detect COVID-19: A Systematic Review and Meta-Analysis
Suklan J et al. · Viruses, 2021
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