Intelligente Bibliothek

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Curated knowledge libraryReference collection

Filters

Registry

All Compounds Conditions RCTs Biographies Jurisdictions

Evidence level

All fda cleared context systematic review rct cohort case series case report preclinical in vitro mechanistic

Safety domain

All infection aeromonas bleeding anemia transfusion allergy anaphylaxis tissue failure ocular risk biohazard disposal

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Conditions

Knee Osteoarthritis

Tier B

Off-label use with three RCTs showing pain and function improvement comparable to NSAID gel at 3 months in mild-to-moderate symptomatic knee OA.

Studied off-labelSystematic review

Compounds

Hirudin Novel Drug Delivery Systems (NDDS)

Systematic review of hirudin novel drug delivery systems addressing the bioavailability + protease-degradation bottleneck — Mo 2024.

Preclinical / mechanisticSystematic review

RCTs

Bivalirudin in patients undergoing primary angioplasty for acute myocardial infarction (HORIZONS-AMI): 1-year results of a randomised controlled trial

GRADE high

Mehran R, Lansky AJ, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Gersh BJ, Pocock SJ, Wong SC, Nikolsky E, Gambone L, Vandertie L, Parise H, Dangas GD, Stone GW (2009) · The Lancet

Systematic review