Thrombosis and Coagulopathy

Effective anticoagulation management is crucial for balancing thromboembolism and hemorrhage risks in patients with traumatic brain injury (TBI) and spinal cord injury (SCI). A systematic review from January 1984 to August 2024 highlights a growing preference for prothrombin complex concentrate (PCC) as the primary reversal agent, with limited evidence on idarucizumab for dabigatran. Most studies show that 4F-PCC improves mortality and hemostatic efficacy, facilitating faster surgical interventions. The lack of large clinical trials remains a significant gap, limiting the development of standardized protocols. Increasing use of viscoelastic assays for assessing residual anticoagulant activity offers potential for more personalized treatment strategies.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Effective anticoagulation management is crucial for balancing thromboembolism and hemorrhage risks in patients with traumatic brain injury (TBI) and spinal cord injury (SCI).

Leech-derived molecules this paper discusses, each with a full profile in the ASH compound registry:

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