Successful Thrombolytic Therapy forMechanical Mitral Valve ThrombosisUsing Bivalirudin-Based Thrombolytic Regimen

Distinguishing the cause of a mechanical valve obstruction as a thrombus or a pannus can be difficult but is critical because pannus can be treated only with surgical valve replacement and thrombus can be treated with surgery or fibrinolytic therapy. This case report describes a patient with a mechanical valve thrombosis and reported allergy to porcine products who was treated by an unusual regimen: ultraslow-infusion, low-dose fibrinolytic therapy with administration of bivalirudin as a bridging anticoagulant.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Distinguishing the cause of a mechanical valve obstruction as a thrombus or a pannus can be difficult but is critical because pannus can be treated only with surgical valve replacement and thrombus can be treated with surgery or fibrinolytic therapy.

Leech-derived molecules this paper discusses, each with a full profile in the ASH compound registry:

Узнайте, как это исследование связано с клинической практикой

More peer-reviewed studies in Клинические исследования.

• Leech Therapy for Knee Osteoarthritis — The Landmark RCT — Michalsen et al. (2003)
• Leech-Assisted Flap Salvage — Systematic Review of 277 Cases — Whitaker et al. (2012)
• Effects of hirudotherapy on liver functions, lipid profile, and insulin sensitivity in rats with metabolic syndrome — Bilden A et al. (2026)
• Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial — Abtahi-Forooshani M et al. (2026)
• Reverse Sural Flap Venous Congestion Successfully Managed With Enoxaparin in a Male Patient With a Traumatic Foot Crush Injury: A Case Report — Velasco-Bustamante J et al. (2026)
• Investigation of the therapeutic effects of medicinal leech treatment on lower extremity ischemia-reperfusion injury — Ünal K et al. (2026)
• Efficacy of Medicinal Leech Therapy in Diverse Clinical Applications: A Comprehensive Study from Azerbaijan — Farzali S et al. (2025)
• HIRUDOTHERAPY IN RECONSTRUCTIVE SURGERY: CASE-REPORTS AND REVIEW — Heinz P et al. (2020)
• Hirudotherapy Efficacy and Complications in the Management of Microsurgical Breast Reconstruction: A Systematic Review — Foppiani J et al. (2024)
• Hirudotherapy in Wound Healing — Nair H et al. (2022)

Browse all ASH-analysed research →