Умная библиотека
Фасетный поиск по всем 5 реестрам. Фильтр по типу реестра, уровню доказательности или области безопасности.
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Compounds
5Hirudin
The most potent natural thrombin inhibitor — and the molecular template for three FDA-approved direct thrombin inhibitor drugs.
Preclinical / mechanisticIn vitro
Antistasin
Factor Xa inhibitor — prototype molecule that inspired the entire DOAC drug class (rivaroxaban, apixaban).
Preclinical / mechanisticIn vitro
Lepirudin
First-generation recombinant hirudin — FDA-approved 1998 for heparin-induced thrombocytopenia (HIT). Withdrawn 2012 by Bayer for commercial reasons.
Studied off-labelFDA-cleared regulatory context
Desirudin
Recombinant hirudin variant — FDA-approved 2003 for prophylaxis of DVT after hip replacement surgery.
Studied off-labelFDA-cleared regulatory context
Leech Histamine-like Vasodilator
Histamine-receptor-acting compound — contributes to local vasodilation at feeding site.
Preclinical / mechanisticMechanistic