Bivalirudin as an anticoagulation strategy for acute hemodialysis in children: Two cases with a summary of recent literature
Research article published in Hemodialysis international (2024)
Abstract
Unfractionated heparin is the most used anticoagulative agent for extracorporeal settings in children, including acute hemodialysis modalities. In certain situations, such as heparin-induced thrombocytopenia, alternatives must be applied. The direct thrombin inhibitor bivalirudin has come forth as an attractive substitute. Bivalirudin is currently only approved for adult use in specific percutaneous coronary intervention settings. However, it has a growing off-label popularity in different contexts for both adult and pediatric patients. Experience with bivalirudin in children is mainly limited to extracorporeal membrane oxygenation, ventricular assist devices and during cardiopulmonary bypass surgery. Literature about its use as anticoagulation strategy for pediatric hemodialysis is very scarce. Here, we present two pediatric cases where bivalirudin was used during acute hemodialysis, followed by a short summary of recent literature.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Bivalirudin as an anticoagulation strategy for acute hemodialysis in children: Two cases with a summary of recent literature.
Por qué esto importa para la hirudoterapia
Este artículo presenta dos informes de casos pediátricos en los que se utiliza bivalirudina, descrita en el resumen como un inhibidor directo de la trombina, como anticoagulante alternativo para la hemodiálisis aguda cuando la heparina no fraccionada está contraindicada, como en la trombocitopenia inducida por heparina, acompañado de un resumen de la literatura reciente. El resumen no hace ninguna mención de hirudina, sanguijuelas ni relación alguna con la hirudoterapia. Por lo tanto, no puede establecerse ninguna conexión defendible con las sanguijuelas ni con ASH únicamente a partir de este resumen. Los datos clínicos se limitan a dos casos más un breve resumen bibliográfico, y constituyen un informe anecdótico de uso fuera de indicación más que evidencia sólida sobre seguridad o eficacia.
Citación
Bivalirudin as an anticoagulation strategy for acute hemodialysis in children: Two cases with a summary of recent literature
Viaene LV et al. · Hemodialysis international, 2024
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026