Anticoagulación basada en bivalirudina frente a anticoagulación convencional con heparina para la oxigenación por membrana extracorpórea poscardiotomía

INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) after cardiac operations (postcardiotomy) is commonly used for the treatment of acute heart failure refractory to drug treatment. Bleeding and thromboembolic events are the most common complications of postcardiotomy ECMO. The present study is a retrospective comparison of the conventional heparin-based anticoagulation protocol with a bivalirudin-based, heparin-free protocol. Endpoints of this study are blood loss, allogeneic blood product use, and costs during the ECMO procedure. METHODS: A retrospective study was undertaken in the setting of cardiac surgery, anesthesia, and intensive care departments of a university research hospital. Twenty-one patients (12 adults and nine children) who underwent postcardiotomy ECMO from 2008 through 2011 were retrospectively analyzed. The first consecutive eight patients were treated with heparin-based anticoagulation (H-group) and the next 13 consecutive patients with bivalirudin-based anticoagulation (B-group). The following parameters were analyzed: standard coagulation profile, thromboelastographic parameters, blood loss, allogeneic blood products use, thromboembolic complications, and costs during the ECMO treatment. RESULTS: Patients in the B-group had significantly longer activated clotting times, activated partial thromboplastin times, and reaction times at thromboelastography. The platelet count and antithrombin activity were not significantly different, but in the H-group a significantly higher amount of platelet concentrates, fresh frozen plasma, and purified antithrombin were administered. Blood loss was significantly lower in the B-group, and the daily cost of ECMO was significantly lower in pediatric patients treated with bivalirudin. Thromboembolic complications did not differ between groups. CONCLUSIONS: Bivalirudin as the sole anticoagulant can be safely used for postcardiotomy ECMO, with a better coagulation profile, less bleeding, and allogeneic transfusions. No safety issues were raised by this study, and costs are reduced in bivalirudin-treated patients.

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En un hospital universitario se compararon retrospectivamente 21 pacientes (12 adultos y 9 niños) en ECMO poscardiotomía: 8 consecutivos con heparina y 13 con bivalirudina. Con bivalirudina hubo tiempos de coagulación activada, TTPa y reacción tromboelastográfica significativamente más largos, significativamente menor pérdida de sangre y menos transfusiones alogénicas; las complicaciones tromboembólicas no difirieron. El coste diario de la ECMO fue significativamente menor en los niños con bivalirudina. Según los autores, la bivalirudina como único anticoagulante puede usarse con seguridad.

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