Bivalirudin for cardiopulmonary bypass in a patient with heparin allergy
Case report published in J Cardiothorac Surg (2023)
Abstract
BACKGROUND: Hypersensitivity reactions to heparin are uncommon conditions but pose a serious clinical problem for patients requiring cardiopulmonary bypass. Bivalirudin is a reversible direct thrombin inhibitor that can be used instead of heparin. CASE REPORT: A 49-year-old male patient was admitted to our hospital for coronary artery bypass graft operation with mitral insufficiency and tricuspid valve insufficiency. Heparin allergy was confirmed by skin biopsy and skin tests. Due to this allergy, we used bivalirudin (Bivacard VEM drug, Turkey) during the surgery. A loading dose of 1.0 mg/kg (100 mg) bivalirudin was administered through the central line and a continuous infusion of 2.5 mg/kg/h of the anticoagulant was initiated following the approved protocol. Serial ACTs were obtained at 15-minute intervals during the procedure and the measurements were 330s, 320s, 350s, 360s, and 340s consecutively. Additional boluses of 0.5 mg/kg (50 mg) were administered for each measurement. Left anterior descending, obtuse marginal arteries and the right coronary artery were grafted with the left internal mammary and saphenous veins. Also, mitral valve replacement with St Jude mechanical heart valve and tricuspid ring annuloplasty was performed with Medtronic Duran ring. After the surgery, the patient had an uneventful period in the postoperative intensive care unit with a total of 600ml and 300ml chest tube drainage for two days and was discharged on the 7th day. CONCLUSION: Alternative anticoagulation strategies are needed for cardiopulmonary bypass in patients unable to use heparin. Bivalirudin may be recommended as a viable alternative anticoagulant in patients with heparin allergy during cardiopulmonary bypass. However, each patient should be evaluated individually and it should not be forgotten that more than recommended doses may be needed.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Zusammenfassung
Hypersensitivity reactions to heparin are uncommon conditions but pose a serious clinical problem for patients requiring cardiopulmonary bypass.
Warum dies für die Hirudotherapie relevant ist
Dieser Fallbericht beschreibt den Einsatz von Bivalirudin – im Abstract als reversibler direkter Thrombininhibitor charakterisiert – als Alternative zu Heparin zur Antikoagulation während eines kardiopulmonalen Bypasses bei einem 49-jährigen Mann mit durch Hautbiopsie und Hauttests bestätigter Heparinallergie. Eine Aufsättigungsdosis von 1,0 mg/kg gefolgt von einer kontinuierlichen Infusion von 2,5 mg/kg/h wurde verabreicht, mit serieller Activated-Clotting-Time-Überwachung in 15-Minuten-Intervallen und zusätzlichen Boli; der Patient erholte sich komplikationslos und wurde am siebten postoperativen Tag entlassen. Das Abstract erwähnt weder Blutegel noch Hirudin oder Hirudotherapie und liefert keine Informationen, die Bivalirudin mit dem Blutegel-Sekretom oder einer leechstämmigen Verbindung in Verbindung bringen. Einschränkung: Es handelt sich um einen einzelnen Fallbericht zu einem pharmazeutischen Antikoagulans; basierend allein auf dem Abstract besteht keine direkte Relevanz für Hirudotherapie oder ASHs Fachgebiet.
Zitation
Bivalirudin for cardiopulmonary bypass in a patient with heparin allergy.
Boysan E et al. · J Cardiothorac Surg, 2023
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