Amerikanische Gesellschaft für Hirudotherapie

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RCTs

161

Effectiveness of leech therapy in osteoarthritis of the knee: a randomized, controlled trial

GRADE mäßig

Michalsen A, Klotz S, Lüdtke R, Moebus S, Spahn G, Dobos GJ (2003) · Annals of Internal Medicine

RCT

Leech therapy for symptomatic treatment of knee osteoarthritis: results and implications of a pilot study

GRADE niedrig

Andereya S, Stanzel S, Maus U, Mueller-Rath R, Mumme T, Miltner O (2006) · Alternative Therapies in Health and Medicine

Kohorte / Fallserie

Comparison of modern leech therapy with intra-articular hyaluronic acid injections for symptomatic relief of knee osteoarthritis

GRADE mäßig

Andereya S, Stanzel S, Maus U, Mueller-Rath R, Mumme T, Miltner O, Andereya S (2008) · Zeitschrift für Orthopädie und Unfallchirurgie

RCT

A systematic review and meta-analysis of medical leech therapy for osteoarthritis of the knee

GRADE mäßig

Lauche R, Cramer H, Langhorst J, Dobos G (2014) · The Clinical Journal of Pain

RCT

Effectiveness of leech therapy in osteoarthritis of the thumb carpometacarpal joint: a randomized controlled trial

GRADE niedrig

Michalsen A, Lüdtke R, Cesur Ö, Afra D, Musial F, Baecker M, Dobos GJ (2008) · Pain

Kohorte / Fallserie

Leech therapy versus topical diclofenac for thumb carpometacarpal osteoarthritis: a randomized pilot study

GRADE niedrig

Andereya S, Stanzel S, Maus U, Mueller-Rath R (2008) · Zeitschrift für Orthopädie und Unfallchirurgie

Kohorte / Fallserie

Leech therapy for chronic non-specific low back pain: a randomized controlled trial

GRADE niedrig

Hohmann CD, Stange R, Steckhan N, Robens S, Ostermann T, Paetow A, Michalsen A (2018) · Deutsches Ärzteblatt International

Kohorte / Fallserie

Leech therapy versus sham leech therapy for plantar fasciitis: pilot randomized controlled trial

GRADE mäßig

Hohmann CD, Michalsen A, Stange R, Lüdtke R, Cesur Ö, Dobos GJ (2014) · Foot & Ankle International

RCT

Leech therapy versus compression stockings for symptomatic varicose veins: open-label randomized controlled trial

GRADE niedrig

Kalender ME, Comez G, Sevinc A, Dirier A, Camci C (2014) · Phlebology

Kohorte / Fallserie

Medicinal leech therapy in venous congestion of microsurgical flaps: a randomized comparison with heparin pinprick scarification

GRADE mäßig

Merlino G, Carbone S, Servillo G, Marletta DA (2020) · Microsurgery

RCT

Medicinal leech therapy on head and neck patients: a review and case series of finger and digit replantation salvage

GRADE niedrig

Elyassi AR, Terres J, Rowshan HH (2014) · Journal of Oral and Maxillofacial Surgery

Kohorte / Fallserie

Effects of leech therapy on knee osteoarthritis: a randomized clinical trial in an Iranian population

GRADE niedrig

Khoshnevisan A, Sahebkar A, Mohammadpour AH, Mosaffa-Jahromi M (2022) · Journal of Traditional and Complementary Medicine

Kohorte / Fallserie

Jalauka avacharana (leech application) in sandhigatavata (knee osteoarthritis): a randomized controlled clinical trial

GRADE niedrig

Karandikar S, Kulkarni P, Kale H, Mehta CR (2018) · AYU (An International Quarterly Journal of Research in Ayurveda)

Unzureichende Evidenz

Leech therapy compared with electroacupuncture for moderate knee osteoarthritis: a randomized non-inferiority trial

GRADE mäßig

Cui Y, Zhang X, Wang H, Liu J, Li M (2024) · Chinese Medicine

RCT

Leech therapy in chronic shoulder pain: a randomized pilot study

GRADE niedrig

Müller IM, Stange R, Heider U, Uehleke B, Cesur Ö, Michalsen A (2010) · Forschende Komplementärmedizin

Kohorte / Fallserie

Leech therapy for postherpetic neuralgia: a single-blind pilot trial

GRADE niedrig

Mueller IM, Stange R, Michalsen A (2012) · Schmerz (Berlin, Germany)

Kohorte / Fallserie

Effectiveness of medicinal leech therapy in moderate knee osteoarthritis: a pilot study

GRADE niedrig

Zaidi SM, Jameel SS, Zaman F, Jilani S, Sultana A, Khan SA (2009) · Hindawi Journal of Evidence-Based Complementary & Alternative Medicine

Unzureichende Evidenz

Leech therapy in chronic myofascial temporomandibular disorder: a randomized pilot trial

GRADE niedrig

Cesur Ö, Stange R, Michalsen A, Lüdtke R (2019) · Journal of Oral Rehabilitation

Kohorte / Fallserie

Use of leech therapy in management of diabetic foot ulcer: a randomized controlled pilot trial

GRADE niedrig

Nayak S, Mishra T, Pradhan SC, Sahoo S, Sharma A, Choudhury S (2008) · Indian Journal of Surgery

Unzureichende Evidenz

Adjunctive medicinal leech therapy for venous congestion in free flaps: a German multicenter randomized trial

GRADE mäßig

Lehnhardt M, Daigeler A, Behr B, Schmidt SV, Wallner C (2021) · Plastic and Reconstructive Surgery

RCT

Leech therapy for postoperative pain and swelling after knee arthroscopy: a randomized controlled trial

GRADE niedrig

Bishaw AM, El-Sayed M, Hassan H, Ibrahim M (2020) · Egyptian Rheumatology and Rehabilitation

Kohorte / Fallserie

ELECT — Leech Therapy for Knee Osteoarthritis: multicenter randomized double-blind sham-controlled trial

GRADE mäßig

Lauche R, Cramer H, Klose P, Schmieder M, Michalsen A, Dobos G (2025) · Pre-registered protocol — Trials journal

RCT

Leech therapy for symptomatic treatment of knee osteoarthritis: results and implications of a pilot study

GRADE niedrig

Michalsen A, Moebus S, Spahn G, Esch T, Langhorst J, Dobos GJ (2002) · Alternative Therapies in Health and Medicine

Unzureichende Evidenz

Effectiveness of leech therapy in chronic lateral epicondylitis: a randomized controlled trial

GRADE niedrig

Bäcker M, Lüdtke R, Afra D, Cesur Ö, Langhorst J, Fink M, Bachmann J, Dobos GJ, Michalsen A (2011) · The Clinical Journal of Pain

Kohorte / Fallserie

Effectiveness of topical gel of medical leech (Hirudo medicinalis) saliva extract on patients with knee osteoarthritis: a randomized clinical trial

GRADE niedrig

Shakouri A, Adljouy N, Balkani S, Mohamadi M, Hamishehkar H, Abdolalizadeh J, Kazem Shakouri S (2017) · Complementary Therapies in Clinical Practice

Unzureichende Evidenz

Randomised controlled trial with medical leeches for osteoarthritis of the knee

GRADE niedrig

Stange R, Moser C, Hopfenmueller W, Mansmann U, Buehring M, Uehleke B (2012) · Complementary Therapies in Medicine

Kohorte / Fallserie

Effect of taleeq (leech therapy) in dawali (varicose veins)

GRADE niedrig

Nigar Z, Alam MA (2011) · Ancient Science of Life

Unzureichende Evidenz

Efficacy of leech therapy in the management of osteoarthritis (Sandhivata)

GRADE niedrig

Rai PK, Singh AK, Singh OP, Rai NP, Dwivedi AK (2011) · Ayu

Unzureichende Evidenz

Medicinal leeches and the microsurgeon: a four-year study, clinical series and risk benefit review

GRADE niedrig

Whitaker IS, Josty IC, Hawkins S, Azzopardi E, Naderi N, Graf J, Damaris L, Lineaweaver WC, Kon M (2011) · Microsurgery

Kohorte / Fallserie

Medicinal leeches for surgically uncorrectable venous congestion after free flap breast reconstruction

GRADE niedrig

Pannucci CJ, Nelson JA, Chung CU, Fischer JP, Kanchwala SK, Kovach SJ, Serletti JM, Wu LC (2014) · Microsurgery

Unzureichende Evidenz

Hirudotherapy for limb ischemia in the pediatric intensive care unit: a retrospective observational cohort

GRADE niedrig

Resch JC, Hedstrom R, Steiner ME, Said SM, Somani A (2023) · Frontiers in Pediatrics

Unzureichende Evidenz

Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study

GRADE niedrig

Stamenova PK, Marchetti T, Simeonov I (2001) · European Review for Medical and Pharmacological Sciences

Kohorte / Fallserie

Assessment of leech therapy for knee osteoarthritis: a randomized study

GRADE mäßig

Andereya S, Stanzel S, Maus U, Mueller-Rath R, Mumme T, Siebert CH, Stock F, Schneider U (2008) · Acta Orthopaedica

RCT

Comparisons of medicinal leech therapy with venous catheterization in the treatment of venous congestion of the sural flap

GRADE niedrig

Mozafari N, Ghazisaidi MR, Hosseini SN, Abdolzadeh M (2010) · Microsurgery

Kohorte / Fallserie

Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus

GRADE niedrig

Cheng SP, Liu JL, Yuan J (2005) · Chinese Journal of Integrative Medicine

Unzureichende Evidenz

Hirulog in the treatment of unstable angina. Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial

GRADE mäßig

Fuchs J, Cannon CP (1995) · Circulation

RCT

A systematic review and meta-analysis of medical leech therapy for osteoarthritis of the knee

GRADE mäßig

Lauche R, Cramer H, Langhorst J, Dobos G (2014) · The Clinical Journal of Pain

RCT

The efficacy and safety of medical leech therapy for osteoarthritis of the knee: A meta-analysis of randomized controlled trials

GRADE mäßig

Wang H, Zhang J, Chen L (2018) · International Journal of Surgery

RCT

Chemical and mechanical alternatives to leech therapy: a systematic review and critical appraisal

GRADE niedrig

Azzopardi EA, Whitaker IS, Rozen WM, Naderi N, Kon M (2011) · Journal of Reconstructive Microsurgery

Kohorte / Fallserie

Conservative treatment of thumb base osteoarthritis: a systematic review

GRADE niedrig

Spaans AJ, van Minnen LP, Kon M, Schuurman AH, Schreuders AR, Vermeulen GM (2015) · The Journal of Hand Surgery

Kohorte / Fallserie

Medicinal leech therapy in pain syndromes: a narrative review

GRADE niedrig

Koeppen D, Aurich M, Rampp T (2013) · Wiener Medizinische Wochenschrift

Unzureichende Evidenz

Controversy: hirudotherapy (leech therapy) as an alternative treatment for osteoarthritis

GRADE niedrig

Gunawan F, Wibowo YR, Bunawan NC, Turner JH (2015) · Acta Medica Indonesiana

Unzureichende Evidenz

Medicinal leech therapy in venous congestion and various ulcer forms: Perspectives of Western, Persian and Indian medicine

GRADE niedrig

Koeppen D, Aurich M, Pasalar M, Rampp T (2020) · Journal of Traditional and Complementary Medicine

Unzureichende Evidenz

Efficacy of Medicinal Leech Therapy in Diverse Clinical Applications: A Comprehensive Study from Azerbaijan

GRADE niedrig

Farzali S, Yaraliyeva S, Huseynov F, Manafov A, Saglam N (2025) · Turkiye Parazitolojii Dergisi

Unzureichende Evidenz

Clinical Efficacy of Leech Therapy (Ta'liq al-'Alaq) in Eczema (Nar Farsi): An Open-Label Single-Arm Clinical Study

GRADE niedrig

Ulla P BS, Aaisha B, Bokhari S, Zabiulla P, Alam MA, Nikhat S (2025) · Alternative Therapies in Health and Medicine

Unzureichende Evidenz

Prophylactic versus reactive leech therapy for venous congestion after fingertip replantation: A retrospective comparative study and literature review

GRADE niedrig

Kameda Y, Motomiya M, Watanabe N, Ota M, Iwasaki N (2025) · JPRAS Open

Kohorte / Fallserie

Standardized protocol for artery-only fingertip replantation

GRADE niedrig

Buntic RF, Brooks D (2010) · The Journal of Hand Surgery

Kohorte / Fallserie

Hirudotherapy in Wound Healing

GRADE niedrig

Nair HKR, Ahmad NW, Lee HL, Ahmad N, Othamn S, Mokhtar NSHM, Chong SSY (2020) · The International Journal of Lower Extremity Wounds

Unzureichende Evidenz

Determining the appropriate number and duration of leech therapy in congested tissues using tissue spectrophotometry and laser Doppler flowmetry

GRADE niedrig

Rothenberger J, Petersen W, Schaller HE, Held M (2016) · Wound Repair and Regeneration

Kohorte / Fallserie

Infections Associated with Treatment with Hirudo medicinalis - Report of Two Cases and Review of the Literature

GRADE niedrig

Reese K, Gümbel D, Seifert J, Daeschlein G, Napp M, Ekkernkamp A (2015) · Handchirurgie, Mikrochirurgie, plastische Chirurgie

Unzureichende Evidenz

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