Novel CRA Protein from Hirudo medicinalis — Complement Regulation

Identification and characterization of a novel complement-regulatory activity (CRA) protein from Hirudo medicinalis salivary gland secretion. The protein modulates complement cascade activation, adding a new immunomodulatory mechanism to the leech’s multi-compound therapeutic arsenal.

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More peer-reviewed studies in Фармакология секрета слюнных желёз.

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• Draft Genome of Hirudo medicinalis — BMC Genomics — Kvist S et al. (2020)
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• Comparative Transcriptomics of Three Hirudo Species — Babenko VV et al. (2020)
• Effects of hirudotherapy on liver functions, lipid profile, and insulin sensitivity in rats with metabolic syndrome — Bilden A et al. (2026)
• Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial — Abtahi-Forooshani M et al. (2026)
• [Medicinal leeches and hirudotherapy] — Gödekmerdan A et al. (2011)