Metabolomics-based study reveals the effect of lead (Pb) in the culture environment on Whitmania pigra
Research article published in Scientific reports (2020)
Abstract
Whitmania pigra, called Mahuang (MH) in Chinese, has been used as a traditional Chinese medicine for many years and is susceptible to Pb exposure in aquaculture environments. To understand the impact of Pb in the culture environment on MHs, we carried out a 50-day culture of MHs in environments with different levels of Pb pollution. Then, tissue samples of MHs reared in the different Pb-polluted environments were collected and analysed by UPLC-Q/TOF-MS. The results showed that the Pb residue in MHs increased with increasing Pb in the culture environment. There was no significant difference in MH Pb content (P < 0.05) between the low-Pb residue group (PbL) and the blank control group (BC), and those of the middle-Pb residue group (PbM) and the high-Pb residue group (PbH) were significantly different from that of the BC group. Metabolomics results showed significant changes in 24 metabolites in the PbL, PbM and PbH groups, some of which were dose-dependent. These metabolites were mainly lipids, nucleotides, and dipeptides, which are involved in metabolic pathways such as glycerophospholipid metabolism, sphingolipid metabolism, and nucleotide metabolism. Overall, the results proved that metabolomics can be an effective tool to understand the effects of Pb on the metabolic responses of MHs.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Резюме
Whitmania pigra, called Mahuang (MH) in Chinese, has been used as a traditional Chinese medicine for many years and is susceptible to Pb exposure in aquaculture environments.
Почему это важно для гирудотерапии
Данное исследование изучало влияние накопления свинца (Pb) в условиях аквакультуры на метаболический профиль пиявки Whitmania pigra (используемой в традиционной китайской медицине) в течение 50-дневного периода культивирования, продемонстрировав дозозависимое накопление остаточного Pb и значительные изменения 24 метаболитов, затрагивающих метаболизм глицерофосфолипидов, сфинголипидов и нуклеотидов. Пиявка Whitmania pigra является единственной связью со сферой ASH; в аннотации она охарактеризована как средство традиционной китайской медицины, но не обсуждаются гирудотерапия, клинические применения или секретом пиявки. Исследование ограничено химическим/метаболомным анализом тканей пиявок, подвергшихся воздействию Pb, и не затрагивает терапевтические исходы или клиническое применение.
Цитирование
Metabolomics-based study reveals the effect of lead (Pb) in the culture environment on Whitmania pigra
Luo X et al. · Scientific reports, 2020
Связанный клинический контекст
Узнайте, как это исследование связано с клинической практикой
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