Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities.
Review published in Frontiers in bioscience : a journal and virtual library (2006)
Abstract
The anticoagulant protein C system is a dual function cofactor-dependent system. On one hand, it is designed to regulate coagulation, maintain the fluidity of the vasculature and prevent thrombosis. On the other hand, the protein C pathway provides anti-inflammatory and cytoprotective activities. Protein C, a vitamin K-dependent serine protease zymogen that circulates in plasma, is converted by limited proteolysis to activated protein C (APC) by the thrombin-thrombomodulin-endothelial protein C receptor complex on endothelial surfaces. APC and the cofactors of the protein C pathway exert two major distinct types of activities, namely a well-studied anticoagulant activity and a more recently revealed cytoprotective activity due to direct effects on cells. Because of these pleiotropic properties, APC and the protein C pathway components have important roles in the body's host-defense system and provide opportunities for therapeutic treatment of complex and challenging medical disorders, including thrombosis, severe sepsis and stroke.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
The anticoagulant protein C system is a dual function cofactor-dependent system. On one hand, it is designed to regulate coagulation, maintain the fluidity of the vasculature and prevent thrombosis.
Por qué esto importa para la hirudoterapia
Esta revisión examina la doble funcionalidad de la vía de la proteína C activada (APC), detallando sus propiedades anticoagulantes bien establecidas junto con sus actividades antiinflamatorias y citoprotectoras reconocidas más recientemente. Se analiza cómo la naturaleza pleiotrópica de la APC y sus cofactores ofrece oportunidades terapéuticas para trastornos médicos complejos como la trombosis, la sepsis grave y el accidente cerebrovascular. Este artículo no tiene relevancia directa para la American Society of Hirudotherapy: el resumen se enfoca estrictamente en la vía endógena de la proteína C humana y no menciona sanguijuelas, hirudina, hirudoterapia ni ningún producto derivado de sanguijuelas. No se puede establecer ninguna conexión con el secretoma de la sanguijuela a partir de la información proporcionada.
Citación
Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities.
Mosnier et al. · Frontiers in bioscience : a journal and virtual library, 2006
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 28, 2026 · Última actualización del sitio: 18 de junio de 2026