The beneficial roles of metformin on the brain with cerebral ischaemia/reperfusion injury
Review published in Pharmacological research (2019)
Abstract
Cerebral ischaemia/reperfusion (I/R) injury is the transient loss, followed by rapid return, of blood flow to the brain. This condition is often caused by strokes and heart attacks. The underlying mechanisms resulting in brain damage during cerebral I/R injury include mitochondrial dysregulation, increased oxidative stress/reactive oxygen species, blood-brain-barrier breakdown, inflammation of the brain, and increased neuronal apoptosis. Metformin is the first-line antidiabetic drug which has recently been shown to be capable of acting through the aforementioned pathways to improve recovery following cerebral I/R injury. However, some studies have suggested that metformin therapy may have no effect or even worsen recovery following cerebral I/R injury. The present review will compile and examine the available in vivo, in vitro, and clinical data concerning the neuroprotective effects of metformin following cerebral I/R injury. Any contradictory evidence will also be assessed and presented to determine the actual effectiveness of metformin treatment in stroke recovery.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Cerebral ischaemia/reperfusion (I/R) injury is the transient loss, followed by rapid return, of blood flow to the brain.
Por qué esto importa para la hirudoterapia
Esta revisión recopiló y examinó los datos in vivo, in vitro y clínicos disponibles sobre los efectos neuroprotectores de la metformina tras la lesión por isquemia/reperfusión cerebral, incluyendo mecanismos que involucran la desregulación mitocondrial, el estrés oxidativo, la ruptura de la barrera hematoencefálica, la inflamación y la apoptosis. La revisión también señaló evidencia contradictoria que sugiere que la metformina podría no tener efecto o empeorar los desenlaces. Advertencia: esta revisión no menciona sanguijuelas, hirudina, terapia con sanguijuelas ni el secretoma de la sanguijuela; no tiene una relevancia identificable para la hirudoterapia ni para el dominio de ASH.
Citación
The beneficial roles of metformin on the brain with cerebral ischaemia/reperfusion injury
Leech T et al. · Pharmacological research, 2019
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026