Icaridin-Loading Nitrocellulose As a New Repellent Against Aquatic Leech with Waterproof and Long-Acting Properties
Basic science / preclinical published in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2022)
Abstract
Leech attachment is a common nuisance to outdoor recreationists and farmers in aquatic environments. Consequences include bleeding, infection, and, rarely, death. Methods to prevent leech attachment are anecdotal and individual; effective repellent formulations with universal applicability are needed. In this study, icaridin is demonstrated to be repellent and toxic to aquatic leech, and formulation of icaridin loading nitrocellulose (Icar-Nitr) is proposed as a new leech repellent. The nitrocellulose provided sustained drug release and waterproof properties. One optimal formulation, 10-Icar-Nitr, proved effective for leech repelling in aquatic environment. Using a rat model, the same formulation also showed removal and killing after leech attachment. The nitrocellulose reduced percutaneous absorption of icaridin, and 10-Icar-Nitr showed good biocompatibility. This study provides a potential new and practicable strategy for prevention and removal against leech attachment and bites.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Leech attachment is a common nuisance to outdoor recreationists and farmers in aquatic environments. Consequences include bleeding, infection, and, rarely, death.
Por qué esto importa para la hirudoterapia
Este estudio examinó una formulación de nitrocelulosa cargada con icaridina (Icar-Nitr) diseñada para repeler, retirar y matar sanguijuelas acuáticas, evaluando sus propiedades de liberación sostenida, impermeabilidad y biocompatibilidad mediante un modelo en rata. Para el dominio de ASH, la conexión es limitada e inversa: el trabajo se refiere a la prevención y eliminación de la fijación de sanguijuelas como molestia, más que a cualquier aplicación terapéutica de las sanguijuelas o de su secretoma salival. Si bien aborda las interacciones entre la sanguijuela y la piel del huésped, no involucra la terapia con sanguijuelas medicinales, y el contexto de sanguijuelas acuáticas y la finalidad profiláctica difieren sustancialmente de la hirudoterapia controlada. Los hallazgos son preclínicos, se basan en un modelo animal y están orientados a la repelencia anti-sanguijuela, lo que hace que su relevancia directa para la aplicación terapéutica de sanguijuelas sea esencialmente insignificante.
Citación
Icaridin-Loading Nitrocellulose As a New Repellent Against Aquatic Leech with Waterproof and Long-Acting Properties.
Zeng W et al. · Vector borne and zoonotic diseases (Larchmont, N.Y.), 2022
Contexto clínico relacionado
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Añadido a la biblioteca ASH: March 18, 2026 · Última actualización del sitio: June 18, 2026