Titration of Bivalirudin Infusion in the Pediatric Cardiac Catheterization Laboratory: A Case Report

Case report published in A&A Pract (2019)

Última actualización: June 18, 2026Revisado por: ASH Editorial Board

Research article — evidence reviewArticle reference

Evidence: Case reportDesarrollo de fármacosEnsayos clínicosStreiff A et al. · A&A practice, 2019

Abstract

Bivalirudin is a direct thrombin inhibitor that is used as a procedural anticoagulant during percutaneous coronary interventions and cardiac surgery for patients with heparin-resistant thrombosis or heparin-induced thrombocytopenia. There is a robust literature describing its safety and efficacy in adults; however, its use in the pediatric population is relatively rare, with dosing extrapolated from adult data. In this case report, we describe a 4-year-old with complex congenital heart disease and history of heparin-induced thrombocytopenia who required bivalirudin dose uptitration during cardiac catheterization.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeCase ReportsJournal Article

Indexed MeSH termsAntithrombinsCardiac CatheterizationChild, PreschoolHeart DiseasesHirudinsHumansMalePeptide FragmentsRecombinant ProteinsTreatment Outcome

Resumen

Case report of 4-year-old with complex congenital heart disease and HIT requiring bivalirudin uptitration during cardiac catheterization with successful procedural completion.

Por qué esto importa para la hirudoterapia

This case report describes a 4-year-old patient with complex congenital heart disease and a history of heparin-induced thrombocytopenia who required bivalirudin dose uptitration during cardiac catheterization. The abstract notes the paucity of pediatric literature and that dosing is largely extrapolated from adult data. The abstract describes bivalirudin as a direct thrombin inhibitor but does not mention hirudin, leeches, or any leech-derived compound, so no defensible hirudotherapy link exists. This is a single case report involving one patient, does not involve leeches or hirudotherapy, and provides no generalizable dosing conclusions.

Citación

Titration of Bivalirudin Infusion in the Pediatric Cardiac Catheterization Laboratory: A Case Report.

Streiff A et al. · A&A practice, 2019

DOI

Contexto clínico relacionado

Explore cómo esta investigación se conecta con la práctica clínica

Drug Pipeline Drug Development Direct Thrombin Inhibitors Clinical Evidence Clinical Applications Bivalirudin Cardiovascular Cardiology Pediatrics

Aviso legal — investigación y educación

La información en esta página se proporciona únicamente con fines educativos e informativos y no constituye asesoramiento médico, diagnóstico o recomendaciones de tratamiento. Los resúmenes de evidencia clínica reflejan la literatura publicada revisada por pares y no implican eficacia terapéutica fuera de los contextos autorizados por la FDA.

La autorización FDA 510(k) para sanguijuelas medicinales se limita a indicaciones específicas. Las aplicaciones en investigación y fuera de indicación se identifican como tales. Los profesionales deben consultar las directrices vigentes de la FDA, los protocolos institucionales y las normativas estatales aplicables antes del uso clínico.

ASH apoya la evaluación rigurosa basada en evidencia de todas las aplicaciones de hirudoterapia mediante ensayos clínicos controlados e investigación revisada por pares.

Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: June 18, 2026