The Use of Bivalirudin in Pediatric Cardiac Surgery and in the Interventional Cardiology Suite

Anticoagulation is an essential component for patients undergoing cardiopulmonary bypass or extracorporeal membrane oxygenation and for those with ventricular assist devices. However, thrombosis and bleeding are common complications. Heparin continues to be the agent of choice for most patients, likely owing to practitioners' comfort and experience and the ease with which the drug's effects can be reversed. However, especially in pediatric cardiac surgery, there is increasing interest in using bivalirudin as the primary anticoagulant. This drug circumvents certain problems with heparin administration, such as heparin resistance and heparin-induced thrombocytopenia, but it comes with additional challenges. In this manuscript, the authors review the literature on the emerging role of bivalirudin in pediatric cardiac surgery, including its use with cardiopulmonary bypass surgery, extracorporeal membrane oxygenation, ventricular assist devices, and interventional cardiology. Moreover, they provide an overview of bivalirudin's pharmacodynamics and monitoring methods.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Review of bivalirudin pharmacodynamics and use in pediatric cardiac surgery including CPB, ECMO, VAD and interventional cardiology, particularly for heparin resistance and HIT.

Leech-derived molecules this paper discusses, each with a full profile in the ASH compound registry:

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