Management options for pediatric venous thromboembolic disease: Beyond anticoagulation with endovascular therapies.
Review published in Thrombosis research (2024)
Abstract
Venous thromboembolism (VTE) in pediatric patients is an uncommon but serious diagnosis that has an array of therapeutic options and challenges. An assessment of the existing literature on management of pediatric patients with VTE was conducted. The interventions reviewed include anticoagulation, thrombolysis, thrombectomy, inferior vena cava (IVC) filters, and venous stenting. For each intervention, a discussion of mechanism of action, indications, contraindications, and potential complications was performed. While anticoagulants are considered the first-line pediatric VTE treatment, many drugs remain investigational in this patient population and treatment recommendations are extrapolated from adult practice. Thrombolysis may be indicated in cases of acute thrombosis requiring more rapid clot resolution but presents a greater bleeding risk than anticoagulation. Similarly, thrombectomy also provides rapid clot resolution and offers a larger therapeutic window and usage in more mature thrombi than thrombolysis. In select patient groups, IVC filters may be indicated in the prevention of PE but present with inherent thrombogenicity and risk of migration. The data regarding pediatric VTE treatment options, monitoring, and long term outcomes is limited compared to the adult population. The relatively few clinical trials including pediatric patients have a relatively small sample size and are heterogenous with regards to predisposing factors that further exacerbate generalizability. Additional research is needed to help construct and evaluate a robust treatment algorithm for pediatric patients with VTE.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Venous thromboembolism (VTE) in pediatric patients is an uncommon but serious diagnosis that has an array of therapeutic options and challenges. An assessment of the existing literature on management of pediatric patients with VTE was conducted.
Por qué esto importa para la hirudoterapia
Esta revisión evalúa la literatura existente sobre el manejo de la enfermedad tromboembólica venosa pediátrica, incluyendo la anticoagulación, la trombólisis, la trombectomía, los filtros de vena cava inferior y la colocación de stents venosos, con una discusión de los mecanismos, indicaciones, contraindicaciones y complicaciones para cada uno. Los autores señalan que, si bien los anticoagulantes son el tratamiento de primera línea, muchos fármacos siguen en investigación en poblaciones pediátricas y los datos sobre la monitorización y los resultados a largo plazo son limitados. El resumen no contiene ninguna mención de sanguijuelas, hirudoterapia, compuestos derivados de sanguijuelas ni del secretoma de la sanguijuela. No existe una conexión defendible con el ámbito de la ASH, ya que la revisión evalúa exclusivamente terapias endovasculares convencionales y agentes farmacéuticos.
Citación
Management options for pediatric venous thromboembolic disease: Beyond anticoagulation with endovascular therapies.
Mitta et al. · Thrombosis research, 2024
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Añadido a la biblioteca ASH: May 28, 2026 · Última actualización del sitio: 18 de junio de 2026