Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis
Meta-analysis published in Acta Pharmacol Sin (2015)
Abstract
AIM: To conduct a systematic review and meta-analysis to assess the current evidence available regarding the promoting blood circulation and removing blood stasis (PBCRBS) therapy for Chinese patients with acute intracerebral hemorrhage (ICH). METHODS: Six databases were searched from their inception to November 2013. The studies assessed in ≥ 4 domains with 'yes' were selected for detailed assessment and meta-analysis. The herbal compositions for PBCRBS therapy for acute ICH patients were also assessed. RESULTS: From the 6 databases, 292 studies claimed randomized-controlled clinical trials (RCTs). Nine studies with 798 individuals were assessed in ≥ 4 domains with 'yes' by using the Cochrane RoB tool. Meta-analysis showed that PBCRBS monotherapy and adjuvant therapy for acute ICH could improve the neurological function deficit, reduce the volume of hematoma and perihematomal edema, and lower the mortality rate and dependency. Moreover, there were fewer adverse effects when compared with Western conventional medication controls. Xueshuantong Injection and Fufang Danshen Injection, Buyang Huanwu Decoction and Liangxue Tongyu formula, and three herbs (danshen root, sanqi and leech) were the most commonly used Chinese herbal patent injections, herbal prescriptions and single herbs, respectively. CONCLUSION: Despite the apparently positive findings, it is premature to conclude that there is sufficient efficacy and safety of PBCRBS for ICH because of the high clinical heterogeneity of the included studies and small number of trials in the meta-analysis. Further large sample-sizes and rigorously designed RCTs are needed.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Nine RCTs (n=798) of PBCRBS therapy including leech for acute intracerebral hemorrhage; meta-analysis showed improvement in neurological deficit and lower mortality vs Western controls.
Por qué esto importa para la hirudoterapia
Esta revisión sistemática y metaanálisis evaluó la terapia promotora de la circulación sanguínea y eliminadora de estasis sanguínea (PBCRBS) para la hemorragia intracerebral aguda en pacientes chinos, evaluando nueve estudios con 798 individuos. El metaanálisis sugirió que la monoterapia y la terapia adyuvante con PBCRBS mejoraron el déficit neurológico, redujeron el hematoma y el volumen del edema perihematomal, y disminuyeron la mortalidad y la dependencia frente a controles convencionales occidentales. Entre las hierbas únicas más utilizadas se encontraban la raíz de danshen, sanqi y la sanguijuela. Esto aporta relevancia indirecta al dominio de ASH al documentar el uso medicinal tradicional de las sanguijuelas dentro de formulaciones herbales chinas para la resolución del hematoma. Sin embargo, la sanguijuela es solo uno de varios componentes en preparaciones multiherbales, los estudios exhibieron alta heterogeneidad clínica y tamaños muestrales pequeños, y los autores concluyen que la evidencia es insuficiente para establecer la eficacia y la seguridad. No se puede atribuir ningún efecto aislado de la sanguijuela.
Citación
Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis.
Li HQ et al. · Acta Pharmacol Sin, 2015
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Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026