Anticoagulation management of patients with long-term warfarin therapy after valve replacement during the perioperative period of pacemaker implantation.
Research article published in International journal of clinical and experimental medicine (2013)
Abstract
BACKGROUND: To explore an optimal management of perioperative anticoagulation for patients with long-term warfarin therapy after valve replacement during the perioperative of pacemaker implantation. METHODS: We retrospectively reviewed consecutive patients undergoing pacemaker implantation who received long-term warfarin therapy after valve replacements at our hospital. They were divided into 3 groups: discontinued group, bridging group and continued group. We analyzed the relationship between different anticoagulation methods during the peri-procedure period and hemorrhage and embolism events. RESULTS: 132 patients were enrolled. There was no significant difference concerning the mean age, sex, concomitant diseases, atrial fibrillation and whether performed pacemaker replacement among 3 groups. The incidence of hematomas was irrespective of the perioperative anticoagulation strategy used (P = 0.125). A strategy involving bridging anticoagulation with therapeutic-dose heparin was associated with an incidence of wound errhysis (P = 0.008). There was no thromboembolism event in these three groups. CONCLUSION: The results showed that there was no significant difference in hematoma rate among continued group, discontinued group, and bridging group, but there was much more wound errhysis in the bridging group. Also, the study shows that if warfarin is continued, it will not increase the risk of bleeding when the International Normalized Ratio (INR) is around 1.7 during the procedure.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Anticoagulation management of patients with long-term warfarin therapy after valve replacement during the perioperative period of pacemaker implantation.
Por qué esto importa para la hirudoterapia
Este estudio retrospectivo comparó tres estrategias de anticoagulación perioperatoria (interrumpida, puente con heparina y mantenimiento de warfarina) en 132 pacientes en tratamiento crónico con warfarina sometidos a implantación de marcapasos tras reemplazo valvular, sin encontrar diferencias significativas en las tasas de hematoma pero observando mayor errisis de la herida en el grupo con puente de heparina y ausencia de eventos tromboembólicos. El resumen aborda el manejo farmacológico anticoagulante alrededor de la implantación de dispositivos y no contiene ninguna referencia a sanguijuelas, hirudoterapia, hirudina ni a ninguna sustancia derivada de sanguijuela. No existe una relevancia defendible con el ámbito de ASH.
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Añadido a la biblioteca ASH: May 28, 2026 · Última actualización del sitio: June 18, 2026