GILZ: a new link between the hypothalamic pituitary adrenal axis and rheumatoid arthritis?
Review published in Immunology and cell biology (2014)
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis is an important regulator of the stress response. In healthy individuals, the HPA axis maintains an equilibrium, ensuring that endogenous glucocorticoid (GC) levels remain within the normal range. However, hypofunction of the HPA axis may have a role in the development of inflammatory diseases, such as rheumatoid arthritis (RA). Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory protein, the expression of which is upregulated by GC. Although GILZ mediates the anti-inflammatory effects of GC, it may not be associated with the adverse effects that are frequently caused by exogenous GC administration. This has raised interest in GILZ potentiation as a therapeutic approach in diseases such as RA, which may mimic the anti-inflammatory effects of GC without causing harmful side effects. This review will outline the involvement of the HPA axis in RA, as a prelude to highlighting emerging evidence regarding the role of GILZ in inflammation control and RA.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
The hypothalamic-pituitary-adrenal (HPA) axis is an important regulator of the stress response.
Por qué esto importa para la hirudoterapia
Esta revisión explora el papel del eje hipotálamo-hipófisis-suprarrenal y la proteína antiinflamatoria cremallera de leucina inducida por glucocorticoides (GILZ) en la artritis reumatoide, discutiendo la potenciación de GILZ como estrategia para imitar los efectos antiinflamatorios de los glucocorticoides sin los efectos adversos nocivos. El artículo analiza las vías endocrinas, la regulación de la expresión de GILZ por glucocorticoides y a GILZ como diana emergente para el control de la inflamación en la AR. El resumen no hace ninguna referencia a sanguijuelas, hirudoterapia o moléculas derivadas de sanguijuelas. En consecuencia, su relevancia para la American Society of Hirudotherapy es completamente indirecta, limitada al contexto clínico compartido de identificar nuevas estrategias de tratamiento antiinflamatorio.
Citación
GILZ: a new link between the hypothalamic pituitary adrenal axis and rheumatoid arthritis?
Eades LE et al. · Immunology and cell biology, 2014
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026