Trombosis venosa cerebral con afectación de la vena de Labbé y del seno sigmoideo izquierdo en una paciente con trombocitopenia inmune tratada con romiplostim: caso clínico y revisión de la literatura

Cerebral venous thrombosis is an uncommon but potentially serious condition primarily affecting young women. Thrombosis of the vein of Labbé is a rare site of thrombosis linked to hemorrhagic venous infarction. Thrombotic events have been reported in patients with chronic primary immune thrombocytopenia (ITP) treated with thrombopoietin receptor agonists (TPO-RAs). A 33-year-old woman with chronic ITP, treated with romiplostim for five years, presented with a progressively worsening occipital headache and a generalized seizure. Computed tomography showed a left parietotemporal intraparenchymal hemorrhage. Magnetic resonance imaging and venography confirmed left sigmoid sinus thrombosis and a hemorrhagic venous infarction caused by thrombosis of the vein of Labbé, along with signs indicating a previous superior sagittal sinus thrombosis. Romiplostim was discontinued after the event, and anticoagulation, along with corticosteroids, was started due to a decline in platelet count. Common causes of cerebral venous thrombosis were investigated and ruled out. The patient was discharged asymptomatic on hospital day 12 and was seen for outpatient follow-up. This case highlights a rare presentation of Labbé vein thrombosis in the setting of long-term use of TPO-RAs and supports a possible association.

Resumen tomado de PubMed (NCBI) para el registro citado, en el idioma original. La versión de referencia es la de la publicación original.

El resumen se deja sin traducir para conservar la redacción original de los autores.

Una mujer de 33 años con trombocitopenia inmune crónica tratada cinco años con romiplostim presentó cefalea occipital progresiva y una crisis generalizada. La tomografía mostró hemorragia intraparenquimatosa parietotemporal izquierda; la resonancia confirmó trombosis del seno sigmoideo izquierdo y de la vena de Labbé con infarto venoso hemorrágico. Se suspendió el romiplostim, se iniciaron anticoagulación y corticoides y fue dada de alta asintomática el día 12. Los autores consideran posible una asociación con agonistas del receptor de trombopoyetina.

Explore cómo esta investigación se conecta con la práctica clínica

Más estudios revisados por pares en la categoría «Ensayos clínicos».

• Leech Therapy for Knee Osteoarthritis — The Landmark RCT — Michalsen et al. (2003)
• Leech-Assisted Flap Salvage — Systematic Review of 277 Cases — Whitaker et al. (2012)
• Effects of hirudotherapy on liver functions, lipid profile, and insulin sensitivity in rats with metabolic syndrome — Bilden A et al. (2026)
• Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial — Abtahi-Forooshani M et al. (2026)
• Reverse Sural Flap Venous Congestion Successfully Managed With Enoxaparin in a Male Patient With a Traumatic Foot Crush Injury: A Case Report — Velasco-Bustamante J et al. (2026)
• Investigación de los efectos terapéuticos del tratamiento con sanguijuelas medicinales sobre la lesión por isquemia-reperfusión de la extremidad inferior — Ünal K et al. (2026)
• Efficacy of Medicinal Leech Therapy in Diverse Clinical Applications: A Comprehensive Study from Azerbaijan — Farzali S et al. (2025)
• HIRUDOTHERAPY IN RECONSTRUCTIVE SURGERY: CASE-REPORTS AND REVIEW — Heinz P et al. (2020)
• Hirudoterapia en la cicatrización de heridas — Nair H et al. (2022)
• Improvement of patient care through hirudotherapy and the management of leeches from their reception to their disposal in France — Vaesken C et al. (2023)

Ver toda la investigación analizada por la ASH →