Leech Kazal-Domain Inhibitor 3
Additional Kazal-family serine protease inhibitor cataloged in Hirudo medicinalis sialotranscriptome — broad serine-protease specificity.
Praeklinisch / mechanistischLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Additional Kazal-family serine protease inhibitor cataloged in Hirudo medicinalis sialotranscriptome — broad serine-protease specificity.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
Clinical translation limit
Sequence-level cataloging of this Kazal-domain inhibitor does NOT establish clinical efficacy. No FDA-approved derivative exists.
Molecular Profile
- Category
- Proteinase Inhibitor
- Evidence tier
- Preclinical
- Molecular weight
- 5,500 Da
- Source species
- Hirudo medicinalis
- Discovered
- 2018
Biological Targets
- → serine proteases (broad)
External Resources
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