Eglin C
Potent inhibitor of human leukocyte elastase and cathepsin G — anti-inflammatory protein widely used as research tool.
Praeklinisch / mechanistischLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Potent inhibitor of human leukocyte elastase and cathepsin G — anti-inflammatory protein widely used as research tool.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
Clinical translation limit
Eglin C is a research-grade biochemical tool; its in vitro inhibition of human leukocyte elastase does not establish clinical anti-inflammatory efficacy. No FDA-approved derivative exists.
Biological Targets
- → leukocyte elastase
- → cathepsin G
- → chymotrypsin
Key Citations
- Seemüller U et al. (1980), FEBS Lett
- Heinz et al. (1992), Biochemistry
External Resources
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