H. yanyuanensis LCI Family Expansion (2025)
Lineage-specific expansion of the leech carboxypeptidase inhibitor (LCI) family in the terrestrial blood-feeding leech Haemadipsa yanyuanensis — Lin 2025.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Lineage-specific expansion of the leech carboxypeptidase inhibitor (LCI) family in the terrestrial blood-feeding leech Haemadipsa yanyuanensis — Lin 2025.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
Clinical translation limit
LCI family expansion is documented at genome / phylogenetic level only; functional characterization pending. No FDA-approved derivative; H. yanyuanensis is not on the FDA K040187 cleared device species list.
Molecular Profile
- Category
- Proteinase Inhibitor
- Evidence tier
- Preclinical
- Source species
- Haemadipsa yanyuanensis
- Discovered
- 2025 · Lin Y et al.
Biological Targets
- → carboxypeptidase B / TAFIa (predicted by LCI homology)
Key Citations
- Lin Y et al. (2025), BMC Genomics · PMID 41469844
External Resources
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