Bdellin A
Trypsin-plasmin inhibitor of Kazal-type family — sister to Bdellin B3.
Praeklinisch / mechanistischLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Trypsin-plasmin inhibitor of Kazal-type family — sister to Bdellin B3.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
Clinical translation limit
Bdellin A's in vitro inhibition of trypsin and plasmin does not establish clinical efficacy. No FDA-approved derivative exists. Mechanism is preclinical/biochemical only.
Molecular Profile
- Category
- Proteinase Inhibitor
- Evidence tier
- Preclinical
- Molecular weight
- 5,300 Da
- Source species
- Hirudo medicinalis
Biological Targets
- → trypsin
- → plasmin
Key Citations
- Fink E et al. (1986), Biol Chem Hoppe-Seyler
External Resources
Related Proteinase Inhibitor Compounds
Hirustasin
Serine proteinase inhibitor targeting tissue kallikrein — anti-inflammatory pathway.
Eglin C
Potent inhibitor of human leukocyte elastase and cathepsin G — anti-inflammatory protein widely used as research tool.
Bdellin B3
Kazal-type proteinase inhibitor targeting trypsin and plasmin — modulates inflammatory cascade.
LDTI (Leech-Derived Tryptase Inhibitor)
Selective inhibitor of human mast cell tryptase — anti-inflammatory pathway.