Publication Tracker — ASH
Live timeline of 9766 PMID-verified articles ASH tracks. Filter by category to explore the literature growth toward our 10,000-paper coverage goal.
This page is the public face of ASH's literature-tracking pipeline. Every entry here is parsed from PubMed metadata directly, cross-checked against the article's real PMID, and committed into the open-source registry behind this site. Hand-curated registries are tracked separately at PMID Audit Status.
The corpus grows continuously as new PubMed-indexed hirudotherapy and leech-derived-compound papers are published. The 10,000-article goal is the coverage threshold needed to consider ASH's literature surveillance comprehensive across all leech-related biomedical sub-fields.
9766
Total tracked articles
PMID-verified, auto-imported from PubMed
1767
Added in last 12 months
Rolling window ending 2026-05-27
97.7%
Progress toward 10,000-paper goal
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Showing 931 articles in Salivary Pharmacology. Clear filter
Timeline by publication year
2026
39 articlesCurrent yearAndexanet alfa for the reversal of anticoagulation: Dutch practice data
Krommenhoek JF et al. · Research and practice in thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Autoimmune heparin-induced thrombocytopenia following cardiac surgery.
St Bernard R et al. · BMJ case reports
Added to ASH registry: 2026-05-28
Circadian Rhythm and Efficacy of Argatroban in Ischemic Stroke with Alteplase: A Post Hoc Analysis of the ARAIS Trial
Chen et al. · CNS drugs
Added to ASH registry: 2026-05-28
Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review.
Rehman A et al. · World journal of methodology
Added to ASH registry: 2026-05-28
Effects of cardiopulmonary bypass on in vitro proliferation of human pancreatic cancer cells and plasma growth factor levels
Katagiri et al. · Journal of cardiothoracic surgery
Added to ASH registry: 2026-05-28
Emergency reversal of Rivaroxaban with Andexanet alfa in a child with hemorrhagic brain metastasis from Wilms tumor
Rafaelian A et al. · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Added to ASH registry: 2026-05-28
Estrogen upregulates lactoferrin to induce hypercoagulability for hemostatic protection during pregnancy
Cheng R et al. · Blood
Added to ASH registry: 2026-05-28
Excessive Apixaban Concentrations in a Bleeding Patient Treated With Pharmacological Reversal and Extracorporal Removal-A Case Report
Kraus RF et al. · Pharmacology research & perspectives
Added to ASH registry: 2026-05-28
Fondaparinux versus argatroban for the management of suspected or confirmed heparin-induced thrombocytopenia: a propensity score-matched cohort study.
Alfehaid L et al. · Frontiers in medicine
Added to ASH registry: 2026-05-28
Nafamostat Mesilate as an Anticoagulation Strategy for Heparin-Induced Thrombocytopenia: A Case Report.
Mei S et al. · Journal of blood medicine
Added to ASH registry: 2026-05-28
Notch signaling in leech neurogenesis: expression patterns and functional insights in the Glossiphoniid leech.
Jeong et al. · Animal cells and systems
Added to ASH registry: 2026-05-28
Review of the Current Issues Surrounding Monitoring of the Direct Thrombin Inhibitor Argatroban in the Laboratory.
Guy S et al. · International journal of laboratory hematology
Added to ASH registry: 2026-05-28
Salivary Nitrate Maintains Mucosal Homeostasis via the Sialin-Neuropeptide Axis
Li et al. · Journal of dental research
Added to ASH registry: 2026-05-28
Sibakazin: a novel black fly derived non-classical kazal protease inhibitor, targeting antiplatelet (P2Y12/GPVI) pathways without perturbing coagulation
Li Z et al. · Insect biochemistry and molecular biology
Added to ASH registry: 2026-05-28
The unique biogenesis pathway of extracellular vesicles in Hirudo nipponia salivary gland cells
Zhu et al. · Tissue & cell
Added to ASH registry: 2026-05-28
Thrombin generation and the pharmacodynamics of parenteral anticoagulants.
Shaw JR et al. · Pharmacological reviews
Added to ASH registry: 2026-05-28
Use of argatroban as anticoagulation for cardiopulmonary bypass during heart transplantation: A case report.
Faggioli M et al. · Journal of cardiothoracic surgery
Added to ASH registry: 2026-05-28
VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia.
Yamaguchi A et al. · Blood vessels, thrombosis & hemostasis
Added to ASH registry: 2026-05-28
Anticoagulant peptide LR from Whitmania pigra ameliorates cerebral ischemia-reperfusion injury
Liu R et al. · Brain research
Added to ASH registry: 2026-05-27
Anticoagulation associated intracerebral haemorrhage trends, treatment and outcomes in a metropolitan cohort: analysed by availability of specific versus non-specific reversal agents
El-Masri S et al. · BMJ neurology open
Added to ASH registry: 2026-05-27
Anticoagulation Stewardship Program in the DOAC Era
Ng JX et al. · Journal of clinical medicine
Added to ASH registry: 2026-05-27
Construction of Corynebacterium glutamicum for efficient secretion and production of recombinant proteins using the technology of ARTP mutagenesis and fluorescen activated droplet microfluidic screening
Liu X et al. · Bioresource technology
Added to ASH registry: 2026-05-27
Dabigatran-induced Gastrointestinal Bleed Treated by 4-factor Prothrombin Complex Concentrate in a Tertiary Care Hospital in Sikkim
Dhakal M et al. · The Journal of the Association of Physicians of India
Added to ASH registry: 2026-05-27
Duplication of the Antistasin-Like Structure Resulted in a New Anticoagulant Protein in the Medicinal Leech
Brovina KA et al. · Biomolecules
Added to ASH registry: 2026-05-27
Elucidating the Neuroinflammatory Modulatory Mechanisms of Maixuekang Capsule via Network Pharmacology in Cerebral Ischemia/Reperfusion Injury Rats
Han H et al. · Developmental Neurobiology
Added to ASH registry: 2026-05-27
ERGA-BGE reference genome of a once neglected freshwater haematophagous European medicinal leech
Manzano-Marín A et al. · Open research Europe
Added to ASH registry: 2026-05-27
Genetically Encoded Multivalent Elastin-Like Polypeptide-Haemadin Fusion Proteins for Prolonged Antithrombotic Protection
Yang H et al. · Biomacromolecules
Added to ASH registry: 2026-05-27
Hirudin ameliorates kidney injury in DKD mice by decreasing SOD2 β-hydroxybutyrylation mediated ROS level and NLRP3 inflammasome formation
Li Y et al. · FASEB journal
Added to ASH registry: 2026-05-27
Hirudin suppresses ovarian cancer cell proliferation and glycolysis through inhibiting the NF-B/HK3 axis
Guo Y et al. · Gene
Added to ASH registry: 2026-05-27
Identification and characterization of WpDestabilase, a novel destabilase from the salivary glands of Whitmania pigra
Huang B et al. · Protein expression and purification
Added to ASH registry: 2026-05-27
Recombinant Fusion Protein Composed of Hirudin and Annexin A5 Shows Anti-Coagulant Activity In Vitro
Dong H et al. · Applied biochemistry and biotechnology
Added to ASH registry: 2026-05-27
Role of argatroban infusion in controlling clot formation in post-cardiac surgical extracorporeal membrane oxygenation in pediatrics: A case series of three patients
Samhan LM et al. · Perfusion
Added to ASH registry: 2026-05-27
Safety and Outcomes of Dabigatran Reversal With Idarucizumab Before IV Thrombolysis in Patients With Acute Ischemic Stroke
Säflund M et al. · Neurology
Added to ASH registry: 2026-05-27
The great diversity: monomeric and oligomeric hirudins, hirudin-like factors and decorsins in the Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis
Kalatehjari P et al. · Parasitology research
Added to ASH registry: 2026-05-27
Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations
Li W et al. · Frontiers in endocrinology
Added to ASH registry: 2026-05-27
Updates on Use and Monitoring of Direct Thrombin Inhibitors
Navaei A et al. · Clinics in laboratory medicine
Added to ASH registry: 2026-05-27
Molecular Insights into Leech-Derived Bioactive Compounds: Biochemical Mechanisms and Therapeutic Potential
Raghavi S, Deva Darshini B, Saravanan KM, Anbarasu K · International journal of molecular sciences
Added to ASH registry: 2026-05-26
Effects of hirudotherapy on liver functions, lipid profile, and insulin sensitivity in rats with metabolic syndrome
Bilden A et al. · BMC complementary medicine and therapies
Added to ASH registry: 2026-03-18
Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial
Abtahi-Forooshani M et al. · Health science reports
Added to ASH registry: 2026-03-18
2025
74 articlesA UK-wide analysis of 2265 patients receiving a reversal agent for direct oral anticoagulant-associated bleeding.
HaemSTAR Collaborators · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Andexanet Alfa in Emergency Cranial Neurosurgical Procedures: A Bicentric Analysis of Efficacy and Safety
Hounchonou HF et al. · Neurocritical care
Added to ASH registry: 2026-05-28
Andexanet Alfa in Urgent Cardiac Surgery: A Case Report of Edoxaban Reversal for Acute Hemopericardium.
Al Mawed M et al. · The American journal of case reports
Added to ASH registry: 2026-05-28
Anticoagulation and hemostasis in the extracorporeal membrane oxygenation patient.
Saura O et al. · Current opinion in anaesthesiology
Added to ASH registry: 2026-05-28
Bivalirudin for anticoagulation in elderly acute coronary syndrome: Effects on myocardial microcirculation and adverse events.
Cheng CY et al. · World journal of clinical cases
Added to ASH registry: 2026-05-28
Correction of the effect of direct oral and parenteral anticoagulants in hemorrhagic stroke.
Baranich AI et al. · Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
Added to ASH registry: 2026-05-28
Effects of bivalirudin on instant blood-mediated inflammatory reaction after intraportal islet transplantation
Liang et al. · Cell transplantation
Added to ASH registry: 2026-05-28
Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management.
Rivera Jiménez et al. · Medicina (Kaunas, Lithuania)
Added to ASH registry: 2026-05-28
Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway
Lan F et al. · Acta cirurgica brasileira
Added to ASH registry: 2026-05-28
Hirudin promotes peripheral nerve repair and alleviates pain by regulating the EGFR-PI3K/AKT/mTOR pathway
Wu L et al. · Archives of biochemistry and biophysics
Added to ASH registry: 2026-05-28
Hirudin-Like Noninvasive Polyurethane Solid Anticoagulant Fabricated by One-Pot In Situ Solution Polymerization and Phase Conversion Methods
Qu Y et al. · ACS applied materials & interfaces
Added to ASH registry: 2026-05-28
Intravenous thrombolysis for patients with acute ischemic stroke while receiving a direct oral anticoagulant: A systematic review and meta-analysis.
Roberts MZ et al. · Pharmacotherapy
Added to ASH registry: 2026-05-28
Investigating the Therapeutic Potential of Crude Leech Saliva Based on Its Anticancer, Antioxidant, and Anti-Inflammatory Effects
Bilden et al. · Current issues in molecular biology
Added to ASH registry: 2026-05-28
Multiterritory Brain Infarcts, Anticoagulation, and Recurrence After Cryptogenic Stroke: A Subgroup Analysis of the ARCADIA Trial
Gologorsky et al. · Stroke
Added to ASH registry: 2026-05-28
Population Genetics of the Asian Buffalo Leech (Hirudinaria manillensis) in Southern China Based on Mitochondrial Protein-Coding Genes
Lin et al. · Biology
Added to ASH registry: 2026-05-28
Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants.
Chen G et al. · Nature biomedical engineering
Added to ASH registry: 2026-05-28
Rapid Cultivation of Acanthamoeba spp. Isolated from Environmental Samples Using Nanocomposite and Leech Saliva on Non-Nutrient Agar
Bilden et al. · Acta parasitologica
Added to ASH registry: 2026-05-28
Rebalancing agents in hemophilia: knowns, unknowns, and uncertainties.
Van Thillo et al. · Haematologica
Added to ASH registry: 2026-05-28
Recent progress on formulations of hirudin
Bao Z et al. · Pharmaceutical science advances
Added to ASH registry: 2026-05-28
Retraction: Hirudin ameliorates immunoglobulin a nephropathy by inhibition of fibrosis and inflammatory response
Anonymous · Renal failure
Added to ASH registry: 2026-05-28
SYNONYMIZATION OF PLACOBDELLA PICTA (VERRILL, 1872) (HIRUDINEA: GLOSSIPHONIIDAE) WITH DESCRIPTIONS OF TWO NEW SPECIES REVEALED BY MOLECULAR SPECIES DELIMITATION.
Phillips AJ et al. · The Journal of parasitology
Added to ASH registry: 2026-05-28
Targeting thrombin with hirudin alleviates paraquat-induced pulmonary fibrosis via the PAR-1-mediated TGF-β1 pathway.
Hu X et al. · Histology and histopathology
Added to ASH registry: 2026-05-28
Time to hemostatic agent administration increases mortality in veterans with factor Xa inhibitor-related intracranial hemorrhage
Markovic N et al. · The American journal of emergency medicine
Added to ASH registry: 2026-05-28
Tracheal Hirudiniasis Induced by Ingestion of Unboiled Mountain Spring Water
Ni et al. · The American journal of tropical medicine and hygiene
Added to ASH registry: 2026-05-28
Trends and variation in the use of andexanet alfa for the reversal of direct oral anticoagulants in NHS trusts in England
Fisher L et al. · British journal of clinical pharmacology
Added to ASH registry: 2026-05-28
Twenty years of the four-factor prothrombin complex concentrate Octaplex/Balfaxar: A narrative review
Karkouti K et al. · Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
Added to ASH registry: 2026-05-28
Vascular endothelial cell-targeted mRNA delivery via synthetic lipid nanoparticles for venous thrombosis prevention.
Guo et al. · Journal of controlled release : official journal of the Controlled Release Society
Added to ASH registry: 2026-05-28
Volume and Location Analysis of Intracerebral Hemorrhage for the Appropriate Use of Andexanet Alfa
Umemura T et al. · Neurologia medico-chirurgica
Added to ASH registry: 2026-05-28
2025 Guidelines for direct oral anticoagulants: a practical guidance on the prescription, laboratory testing, peri-operative and bleeding management
Tran HA et al. · Internal medicine journal
Added to ASH registry: 2026-05-27
A biomimetic macrophage-membrane-fused liposomal system loaded with GVs-HV recombinant plasmid for targeted anti-atherosclerosis therapy
Zhang Y et al. · Pharmaceutics
Added to ASH registry: 2026-05-27
A novel integrated strategy for discovering absorbable anticoagulant bioactive peptides: a case study on leech protein hydrolysates
Fang KX et al. · Molecules
Added to ASH registry: 2026-05-27
Anticoagulants: from chance discovery to structure-based design
Chan N et al. · Pharmacological reviews
Added to ASH registry: 2026-05-27
Application of promoting blood circulation and resolving blood stasis in intracerebral hemorrhage: a traditional method gradually being reconsidered
Dingshan Z et al. · Journal of traditional Chinese medicine
Added to ASH registry: 2026-05-27
Chromosome-level genome assembly and anticoagulant protein annotation of the buffalo leech Hirudinaria bpling (Hirudinea: Hirudinidae)
Khan MS et al. · BMC genomics
Added to ASH registry: 2026-05-27
Comparative genomics suggests extensive antithrombotic gene expansion in Haemadipsa yanyuanensis
Lin Y et al. · BMC genomics
Added to ASH registry: 2026-05-27
Comparative Study of Hirustasin Superfamily Gene Expression in Two Medicinal Leeches, Hirudinaria manillensis and Whitmania pigra
Sun et al. · Genes
Added to ASH registry: 2026-05-27
Cost-effectiveness of dabigatran for thromboembolic events prevention in atrial fibrillation patients in Chile
Abbot T et al. · Cost effectiveness and resource allocation : C/E
Added to ASH registry: 2026-05-27
Dabigatran-idarucizumab pharmacokinetics-pharmacodynamics in sheep undergoing cardiopulmonary bypass
Eaton MP et al. · Perfusion
Added to ASH registry: 2026-05-27
Distribution and Blood Penetration of Hirudin in Various Organs and Tissues of Rabbits With Carotid Artery Injury by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry
Feng Y et al. · Journal of analytical methods in chemistry
Added to ASH registry: 2026-05-27
Emergency Reversal of Antithrombotics in Intracerebral Hemorrhage: An Update
Li M et al. · Current neurology and neuroscience reports
Added to ASH registry: 2026-05-27
Showing 40 of 74. The full list is in the research library.
2024
59 articlesAllosteric Modulation of Thrombin by Thrombomodulin: Insights from Logistic Regression and Statistical Analysis of Molecular Dynamics Simulations.
Wu D et al. · ACS omega
Added to ASH registry: 2026-05-28
Anticoagulation and Antiplatelet Regimen in Cardiac Transplant. Clinical Characteristics, Outcomes, and Blood Product Transfusion.
Groba Marco MDV et al. · Clinical transplantation
Added to ASH registry: 2026-05-28
Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet-α, protamine).
Bekka E et al. · British journal of clinical pharmacology
Added to ASH registry: 2026-05-28
Beyond Anticoagulation: A Comprehensive Review of Non-Vitamin K Oral Anticoagulants (NOACs) in Inflammation and Protease-Activated Receptor Signaling.
Jannati S et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-28
Challenges to Laboratory Monitoring of Direct Oral Anticoagulants.
Qiao J et al. · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Added to ASH registry: 2026-05-28
Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis.
Yamakawa et al. · International journal of hematology
Added to ASH registry: 2026-05-28
Clinical Presentation, Antimicrobial Resistance, and Treatment Outcomes of Aeromonas Human Infections: A 14-Year Retrospective Study and Comparative Genomics of 2 Isolates From Fatal Cases
Pineda-Reyes R et al. · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Added to ASH registry: 2026-05-28
Direct oral anticoagulants in trauma patients.
Schöchl H et al. · Current opinion in anaesthesiology
Added to ASH registry: 2026-05-28
Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy
Tsikis et al. · American journal of physiology. Lung cellular and molecular physiology
Added to ASH registry: 2026-05-28
Diterpenes Isolated from Three DifferentSpecies and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells.
Gáborová M et al. · ACS omega
Added to ASH registry: 2026-05-28
Efficacy and safety of antithrombotic therapy for preventing and treating pediatric thromboembolic disease: a systematic review.
Gao H et al. · Scientific reports
Added to ASH registry: 2026-05-28
Engineering hirudin encapsulation in pH-responsive antioxidant nanoparticles for therapeutic efficacy in ischemic stroke model mice
Mei T et al. · Biomaterials
Added to ASH registry: 2026-05-28
Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update.
Frol et al. · Frontiers in neurology
Added to ASH registry: 2026-05-28
Immune-stealth VP28-conjugated heparin nanoparticles for enhanced and reversible anticoagulation.
Hussein et al. · Nanotechnology
Added to ASH registry: 2026-05-28
Is bivalirudin ready for a comeback? Pros and cons.
Stone GW et al. · EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Added to ASH registry: 2026-05-28
Letter to the editor: 1-year clinical outcomes of bivalirudin vs. unfractionated heparin in patients with type 2 diabetes undergoing elective percutaneous coronary intervention.
Rajab F et al. · European heart journal. Cardiovascular pharmacotherapy
Added to ASH registry: 2026-05-28
Life cycle and development of the marine leech Branchellion lobata (Hirudinea: Piscicolidae), from round stingrays, Urobatis halleri, from southern California
Lizarraga et al. · Scientific reports
Added to ASH registry: 2026-05-28
Lymphatic Uptake of a Highly Lipophilic Protease Inhibitor Prodrug from a Lipid-Based Formulation is Limited by Instability in the Intestine.
Xie Y et al. · Journal of pharmaceutical sciences
Added to ASH registry: 2026-05-28
Met343Val mutation disrupts the shuttling of Trp380 leading to a low-activity conformer of activated protein C and causes thrombosis.
Zhou et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Meta-Analysis Comparing Bivalirudin Versus. Unfractionated Heparin in Adult Patients With Extracorporeal Membrane Oxygenation
Kido et al. · Journal of pharmacy practice
Added to ASH registry: 2026-05-28
Overdosing of direct oral anticoagulants
Neumann MA et al. · Medizinische Klinik, Intensivmedizin und Notfallmedizin
Added to ASH registry: 2026-05-28
Real-world experience of direct oral anticoagulant use in a single pediatric center.
Valenti GG et al. · Pediatric blood & cancer
Added to ASH registry: 2026-05-28
Reversal of dabigatran and apixaban-induced coagulopathy using idarucizumab, fibrinogen, and prothrombin complex concentrate: A case report.
Morando E et al. · Heliyon
Added to ASH registry: 2026-05-28
Targeting tissue factor pathway inhibitor with concizumab to improve hemostasis in patients with Glanzmann thrombasthenia: an in vitro study.
Dubut et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
The impact of heparin and direct thrombin inhibitors on cell-penetrating polymer siRNA transfection
Mota et al. · Gene therapy
Added to ASH registry: 2026-05-28
Thrombolysis for Ischemic Stroke Despite Recent Ingestion of Direct Oral Anticoagulants - A Growing Dilemma Also in India.
Meinel TR et al. · Annals of Indian Academy of Neurology
Added to ASH registry: 2026-05-28
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice.
Shirani-Bidabadi · Journal of vector borne diseases
Added to ASH registry: 2026-05-28
Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.
Mahoney MW et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-28
A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling
Zoratto N et al. · Advanced science
Added to ASH registry: 2026-05-27
Biomimetic nanoparticles co-deliver hirudin and lumbrukinase to ameliorate thrombus and inflammation for atherosclerosis therapy
Cheng M et al. · Asian journal of pharmaceutical sciences
Added to ASH registry: 2026-05-27
Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo Verbana
Kabeiseman E et al. · Neurochemical research
Added to ASH registry: 2026-05-27
Chromosome-level genome assembly of the cave leech Sinospelaeobdella cavatuses (Hirudinea: Haemadipsidae)
Yao B et al. · Scientific data
Added to ASH registry: 2026-05-27
Combined drug anti-deep vein thrombosis therapy based on platelet membrane biomimetic targeting nanotechnology
Xiao H et al. · Biomaterials
Added to ASH registry: 2026-05-27
Comparative genomics of two Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis: With emphasis on antithrombotic genes and their corresponding proteins
Zhao et al. · International journal of biological macromolecules
Added to ASH registry: 2026-05-27
Comparison of Outcomes in Patients Requiring Mechanical Circulatory Support Who Received Cangrelor in Addition to Anticoagulation Versus Anticoagulation Alone
Martin TC et al. · Journal of cardiothoracic and vascular anesthesia
Added to ASH registry: 2026-05-27
Efficacy and potential mechanism of atherosclerosis prevention by the active components of leech based on network pharmacology combined with animal experiments
Lv Q et al. · Heliyon
Added to ASH registry: 2026-05-27
Evaluation of hemostatic, anti-inflammatory, wound healing, skin irritation and allergy, and antimicrobial properties of active fraction from the ethanol extract of Chromolaena odorata (L.) R.M. King & H. Rob
Li et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-27
Gut microbiota participates and remodels host metabolism: from treating patients to treating their gut flora
Han S et al. · World journal of gastroenterology
Added to ASH registry: 2026-05-27
Heparin-induced DRESS syndrome in a paediatric patient and successful anaesthetic management in cardiovascular bypass surgery: case report
Peña-Blanco L et al. · Journal of cardiothoracic surgery
Added to ASH registry: 2026-05-27
Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis
Zhang J et al. · Biomedicine & pharmacotherapy
Added to ASH registry: 2026-05-27
Showing 40 of 59. The full list is in the research library.
2023
38 articlesAnticoagulant therapies against sepsis-induced disseminated intravascular coagulation.
Umemura et al. · Acute medicine & surgery
Added to ASH registry: 2026-05-28
Bivalirudin plus a high-dose infusion versus heparin in patients with acute coronary syndrome
Galli et al. · European heart journal. Cardiovascular pharmacotherapy
Added to ASH registry: 2026-05-28
Bivalirudin versus Heparin on Net Adverse Clinical Events, Major Adverse Cardiac and Cerebral Events, and Bleeding in Elderly Chinese Patients Treated with Percutaneous Coronary Intervention
Li et al. · The Tohoku journal of experimental medicine
Added to ASH registry: 2026-05-28
Bivalirudin vs heparin in cardiac-cerebral ischemic and bleeding events among Chinese STEMI patients during percutaneous coronary intervention: a retrospective cohort study
Bai et al. · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Added to ASH registry: 2026-05-28
Bivalirudin-hydrogel coatings of polyvinyl chloride on extracorporeal membrane oxygenation for anticoagulation.
Gao W et al. · Frontiers in cardiovascular medicine
Added to ASH registry: 2026-05-28
Cryo-EM structure of coagulation factor V short.
Mohammed et al. · Blood
Added to ASH registry: 2026-05-28
Effectiveness and Safety of Dabigatran Reversal with Idarucizumab in the Taiwanese Population: A Comparison Based on Eligibility for Inclusion in Clinical Trials.
Dai et al. · Medicina (Kaunas, Lithuania)
Added to ASH registry: 2026-05-28
Evidence-based Management of Major Bleeding in Patients Receiving Direct Oral Anticoagulants: An Updated Narrative Review on the Role of Specific Reversal Agents.
Al Aseri Z et al. · Journal of cardiovascular pharmacology and therapeutics
Added to ASH registry: 2026-05-28
Impact of bivalirudin with a post-procedure infusion versus heparin-monotherapy on stent thrombosis and cardiovascular mortality
Shah · Coronary artery disease
Added to ASH registry: 2026-05-28
In Silico and In Vitro Evaluation of Some Amidine Derivatives as Hit Compounds towards Development of Inhibitors against Coronavirus Diseases.
Hassan AHE et al. · Viruses
Added to ASH registry: 2026-05-28
One case of recurrent ST-segment elevation myocardial infarction in a patient with antiphospholipid syndrome complicated with severe thrombocytopenia within a short period of time: A case report.
Qiu Z et al. · Medicine
Added to ASH registry: 2026-05-28
Outcome after intracranial hemorrhage under dabigatran and reversal with idarucizumab versus under vitamin-K-antagonists - the RIC-ICH study.
Kuklik et al. · Frontiers in neurology
Added to ASH registry: 2026-05-28
Platelet function in neonates and children.
Van Den Helm et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Prevalence, Risk Factors and Control Practices of Livestock Hirudiniasis in Mirab Abaya District, Southern Ethiopia
Seyoum et al. · Veterinary medicine (Auckland, N.Z.)
Added to ASH registry: 2026-05-28
Reversing dabigatran effect with idarucizumab to enable intravenous thrombolysis in patients with acute ischaemic stroke - a single centre experience.
Włodarczyk E et al. · Neurologia i neurochirurgia polska
Added to ASH registry: 2026-05-28
The Complete Mitochondrial Genome of Torix tukubana (Annelida: Hirudinea: Glossiphoniidae)
Zhu X et al. · Genes
Added to ASH registry: 2026-05-28
Biomimetic platelet nanomotors for site-specific thrombolysis and ischemic injury alleviation
Chen YT et al. · ACS applied materials & interfaces
Added to ASH registry: 2026-05-27
Bivalirudin in acute coronary syndromes
Galli M et al. · Expert review of cardiovascular therapy
Added to ASH registry: 2026-05-27
Characterization of the natural peptidome of four leeches by integrated proteogenomics and pseudotargeted peptidomics
Liao J et al. · Analytical and bioanalytical chemistry
Added to ASH registry: 2026-05-27
Cloning, characterization, and heterologous expression of a candidate hirudin gene from the salivary gland transcriptome of Hirudo nipponia
Shi P et al. · Scientific reports
Added to ASH registry: 2026-05-27
Ecarin-based methods for measuring thrombin inhibitors
Gosselin RC · Methods in molecular biology
Added to ASH registry: 2026-05-27
Exploiting Chemical Protein Synthesis to Study the Role of Tyrosine Sulfation on Anticoagulants from Hematophagous Organisms
Maxwell JWC et al. · Accounts of chemical research
Added to ASH registry: 2026-05-27
First description study on molecular characterization of Hemiclepsis khankiana (Hirudinea: Glossiphoniidae) in China
He Y et al. · BMC Vet Res
Added to ASH registry: 2026-05-27
From haemadin to haemanorm: Synthesis and characterization of full-length haemadin from the leech Haemadipsa sylvestris and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)
Acquasaliente L et al. · Protein science
Added to ASH registry: 2026-05-27
Functional expression of a thrombin exosite I inhibitor triabin in Escherichia coli and elucidation of the role of key residues in its inhibitory activity
Mo Z et al. · Biochimie
Added to ASH registry: 2026-05-27
Hirudin ameliorates myocardial ischemia-reperfusion injury in a rat model of hemorrhagic shock and resuscitation: roles of NLRP3-signaling pathway
Bai Y et al. · Molecular and cellular biochemistry
Added to ASH registry: 2026-05-27
Identification and Characterization of RK22, a Novel Antimicrobial Peptide from Hirudinaria manillensis against Methicillin Resistant Staphylococcus aureus
Lu X et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Impact of coronary artery disease on clinical outcomes after TAVR: Insights from the BRAVO-3 randomized trial
Feldman D et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Added to ASH registry: 2026-05-27
Isolation and Characterization of Poeciguamerin, a Peptide with Dual Analgesic and Anti-Thrombotic Activity from the Poecilobdella manillensis Leech
Wang et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Molecular cloning and functional analysis of HnSaratin from Hirudo nipponia
Cheng B et al. · Gene
Added to ASH registry: 2026-05-27
Molecular mechanisms underlying hematophagia revealed by comparative analyses of leech genomes
Zheng J et al. · GigaScience
Added to ASH registry: 2026-05-27
Repetitive nociceptive stimulation elicits complex behavioral changes in Hirudo: evidence of arousal and motivational adaptations
Hoynoski J et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-27
Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease
Gong L et al. · Renal failure
Added to ASH registry: 2026-05-27
Yeast surface display of leech hyaluronidase for the industrial production of hyaluronic acid oligosaccharides
Liao L et al. · Eng Microbiol
Added to ASH registry: 2026-05-27
Characterization and antioxidant activities of glycosaminoglycans from dried leech
Shen T et al. · Glycoconjugate journal
Added to ASH registry: 2026-05-26
Intracerebral hirudin injection alleviates cognitive impairment and oxidative stress and promotes hippocampal neurogenesis in rats subjected to cerebral ischemia
Xia X et al. · Neuropathology : official journal of the Japanese Society of Neuropathology
Added to ASH registry: 2026-03-18
Keratitis following leech therapy for periocular eczematous dermatitis: a case report
Özkaya D · BMC complementary medicine and therapies
Added to ASH registry: 2026-03-18
Structural insights into thrombolytic activity of destabilase from medicinal leech
Marin E et al. · Scientific reports
Added to ASH registry: 2026-03-18
2022
19 articlesA Genomic Island of Vibrio cholerae Encodes a Three-Component Cytotoxin with Monomer and Protomer Forms Structurally Similar to Alpha-Pore-Forming Toxins
Herrera A et al. · Journal of bacteriology
Added to ASH registry: 2026-05-28
Cerebral Venous Sinus Thrombosis in Preterm Infants.
Christensen et al. · Stroke
Added to ASH registry: 2026-05-28
Direct oral anticoagulants (DOACs): From the laboratory point of view.
Margetić S et al. · Acta pharmaceutica (Zagreb, Croatia)
Added to ASH registry: 2026-05-28
Platelet tissue factor pathway inhibitor-α dampens cardiac thrombosis and associated fibrosis in mice.
Maroney et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Thrombin cleaves IL-33 and modulates IL-33-activated allergic lung inflammation.
Huang Y et al. · Allergy
Added to ASH registry: 2026-05-28
Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Paulsen RT, Burrell BD · Frontiers in synaptic neuroscience
Added to ASH registry: 2026-05-27
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
Landsem A et al. · Frontiers in immunology
Added to ASH registry: 2026-05-27
Exploring the mechanism of hirudin in the treatment of diabetic kidney disease using network pharmacology combined with molecular docking verification
Xinxin P et al. · Journal of traditional Chinese medicine
Added to ASH registry: 2026-05-27
Hirudin alleviates acute ischemic stroke by inhibiting NLRP3 inflammasome-mediated neuroinflammation: In vivo and in vitro approaches
Li WQ et al. · International Immunopharmacology
Added to ASH registry: 2026-05-27
Hirudin promotes proliferation and osteogenic differentiation of HBMSCs via activation of cyclic guanosine monophosphate (cGMP)/protein kinase-G (PKG) signaling pathway
Cao S et al. · Bioengineered
Added to ASH registry: 2026-05-27
LC-MS/MS method for determination of r-RGD-hirudin in human plasma and its application in pharmacokinetic study
Peng A et al. · Analytical biochemistry
Added to ASH registry: 2026-05-27
Network Pharmacology and In Vitro Experimental Verification Reveal the Mechanism of the Hirudin in Suppressing Myocardial Hypertrophy
Liu M et al. · Frontiers in pharmacology
Added to ASH registry: 2026-05-27
Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
Zhang Z et al. · Cellular and molecular life sciences
Added to ASH registry: 2026-05-27
Purification and characterization of a novel thermostable anticoagulant protein from medicinal leech Whitmania pigra Whitman
Zhang Y et al. · Journal of Ethnopharmacology
Added to ASH registry: 2026-05-27
Tyrosine-O-sulfation is a widespread affinity enhancer among thrombin interactors
Ripoll-Rozada J et al. · Biochemical Society transactions
Added to ASH registry: 2026-05-27
Life without blood: Molecular and functional analysis of hirudins and hirudin-like factors of the Asian non-hematophagous leech Whitmania pigra
Müller C et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-26
Shuxuetong injection and its peptides enhance angiogenesis after hindlimb ischemia by activating the MYPT1/LIMK1/Cofilin pathway
Sun W et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-26
Make it double: identification and characterization of a Tandem-Hirudin from the Asian medicinal leech Hirudinaria manillensis
Lukas P et al. · Parasitology research
Added to ASH registry: 2026-03-18
Serotonin mediates stress-like effects on responses to non-nociceptive stimuli in the medicinal leech Hirudo verbana
Mack D et al. · The Journal of experimental biology
Added to ASH registry: 2026-03-18
Earlier
702 articles (pre-2022)Artificial intelligence based identification of the functional role of hirudin in diabetic erectile dysfunction treatment
Yang et al. · Pharmacological research
Added to ASH registry: 2026-05-28
Batracobdelloides bangkhenensis sp. n. (Hirudinea: Rhynchobdellida), a new leech species parasite on freshwater snails from Thailand
Chiangkul et al. · Parasitology research
Added to ASH registry: 2026-05-28
Description and taxonomic analysis of a tuberculated turtle leech from the Outer Banks, North Carolina, USA, provisionally identified as Placobdella multilineata Moore, 1953 (Hirudinea: Glossiphoniidae)
Sawyer et al. · Zootaxa
Added to ASH registry: 2026-05-28
Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis
Xu et al. · Chinese journal of natural medicines
Added to ASH registry: 2026-05-28
Identification of a substrate-like cleavage-resistant thrombin inhibitor from the saliva of the flea Xenopsylla cheopis
Lu et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Is the South African leech Barbronia gwalagwalensis Westergren & Siddall, 2004 (Hirudinida: Erpobdelliformes: Salifidae) a Paleotropical species?
Klass et al. · Zootaxa
Added to ASH registry: 2026-05-28
Retrospective Analysis of the Effectiveness of a Reduced Dose of Idarucizumab in Dabigatran Reversal.
Stone et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Screening of the Promising Direct Thrombin Inhibitors from Haematophagous Organisms. Part I: Recombinant Analogues and Their Antithrombotic Activity In Vitro.
Kostromina MA et al. · Biomedicines
Added to ASH registry: 2026-05-28
Short tail stories: the hirudin-like factors HLF6 and HLF7 of the Asian medicinal leech, Hirudinaria manillensis.
Müller C et al. · Parasitology research
Added to ASH registry: 2026-05-28
Structure-function of anticoagulant TIX-5, the inhibitor of factor Xa-mediated FV activation.
Maag et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
Zhao B et al. · British journal of pharmacology
Added to ASH registry: 2026-05-27
A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin
Liu Y et al. · Pharmacology research & perspectives
Added to ASH registry: 2026-05-27
Bivalirudin and sirolimus co-eluting coronary stent: Potential strategy for the prevention of stent thrombosis and restenosis
Sane M et al. · International journal of pharmaceutics
Added to ASH registry: 2026-05-27
Diselenide crosslinks for enhanced and simplified oxidative protein folding
Mousa R et al. · Communications chemistry
Added to ASH registry: 2026-05-27
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
Koh CY et al. · Nature Communications
Added to ASH registry: 2026-05-27
Functional morphology of the suckers and teeth of the medicinal leech Hirudo verbana Carena, 1820 (Annelida; Clitellata; Hirudinida): A scanning electron microscope study
Ayhan H et al. · Microsc Res Tech
Added to ASH registry: 2026-05-27
Impact of anemia on short-term outcomes after TAVR: A subgroup analysis from the BRAVO-3 randomized trial
Razuk V et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Added to ASH registry: 2026-05-27
Incidence, predictors, and outcomes associated with acute kidney injury in patients undergoing transcatheter aortic valve replacement: from the BRAVO-3 randomized trial
Chandrasekhar J et al. · Clinical research in cardiology : official journal of the German Cardiac Society
Added to ASH registry: 2026-05-27
Microneedle patch-assisted transdermal administration of recombinant hirudin for the treatment of thrombotic diseases
Men Z et al. · International journal of pharmaceutics
Added to ASH registry: 2026-05-27
NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships
Schmitz T et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification, and Characterization
Linhares DDC et al. · Toxins
Added to ASH registry: 2026-05-27
Pharmacological activities and mechanisms of hirudin and its derivatives — a review
Junren C et al. · Frontiers in pharmacology
Added to ASH registry: 2026-05-27
Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods
Agten SM et al. · Angewandte Chemie
Added to ASH registry: 2026-05-27
Prostaglandin E1 is an efficient molecular tool for forest leech blood sucking
Zheng F et al. · Frontiers in veterinary science
Added to ASH registry: 2026-05-27
Reperfusion After Fibrinolytic Therapy (RAFT): An open-label, multi-centre, randomised controlled trial of bivalirudin versus heparin in rescue percutaneous coronary intervention
Faour A et al. · PloS one
Added to ASH registry: 2026-05-27
Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton's Tyrosine Kinase
Duan R et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
The Origin and Evolution of Antistasin-like Proteins in Leeches (Hirudinida, Clitellata)
Iwama RE et al. · Genome biology and evolution
Added to ASH registry: 2026-05-27
A study of the influence of lead pollution on the anticoagulant activity of Whitmania pigra based on pharmacodynamics and metabolomics research
Chen X et al. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Added to ASH registry: 2026-05-26
A systematic review on Zhilong Huoxue Tongyu capsule in treating cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms and clinical outcomes
Liang P et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-26
Nanoencapsulation of Hirudo medicinalis proteins in liposomes as a nanocarrier for inhibiting angiogenesis through targeting VEGFA in the Breast cancer cell line (MCF-7)
Shakouri A et al. · BioImpacts : BI
Added to ASH registry: 2026-05-26
Effect of hirudin on arterialized venous flap survival in rabbits
Liu J et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Added to ASH registry: 2026-03-18
Leech therapy (Hirudo medicinalis) attenuates testicular damages induced by testicular ischemia/reperfusion in an animal model
Davoodi F et al. · BMC veterinary research
Added to ASH registry: 2026-03-18
Leech therapy in the treatment of a penile haematoma in a stallion
Nowicki A, Jaworska J, Baranski W · Veterinarni medicina
Added to ASH registry: 2026-03-18
Recombinant Destabilase from Hirudo medicinalis Is Able to Dissolve Human Blood Clots In Vitro
Bobrovsky P et al. · Current issues in molecular biology
Added to ASH registry: 2026-03-18
A new species of buffalo leech in the genus Hirudinaria Whitman, 1886 (Arhynchobdellida, Hirudinidae) from Thailand
Jeratthitikul E et al. · ZooKeys
Added to ASH registry: 2026-05-28
Analysis of anticoagulation reversal survey (ARES).
Rowe et al. · Hospital practice (1995)
Added to ASH registry: 2026-05-28
Antiphospholipid Syndrome Committee of the Brazilian Society of Rheumatology position statement on the use of direct oral anticoagulants (DOACs) in antiphospholipid syndrome (APS).
Balbi GGM et al. · Advances in rheumatology (London, England)
Added to ASH registry: 2026-05-28
Antithrombotic Therapy in Patients with Acute Coronary Syndrome and Atrial Fibrillation
Darius · Deutsche medizinische Wochenschrift (1946)
Added to ASH registry: 2026-05-28
Argatroban dosing requirements in extracorporeal life support and other critically ill populations.
Dingman et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Clinical Outcomes of Bivalirudin Versus Heparin in Elderly Patients Undergoing Percutaneous Coronary Intervention: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
Meng S et al. · Cardiovascular drugs and therapy
Added to ASH registry: 2026-05-28
Showing 40 of 702. The full list is in the research library.