WP-Anticoagulant Genes (7-Transcript Family)
Whitmania pigra salivary anticoagulant gene family (Huang 2026 transcriptome) — seven coagulation-related transcripts including fibrinolytic enzymes, neutrophil-elastase inhibitors, factor Xa inhibitors.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Whitmania pigra salivary anticoagulant gene family (Huang 2026 transcriptome) — seven coagulation-related transcripts including fibrinolytic enzymes, neutrophil-elastase inhibitors, factor Xa inhibitors.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
These seven anticoagulation-related transcripts are identified by sequence homology only. Functional characterization beyond WpDestabilase has not been completed. No FDA-approved derivative exists; W. pigra is not the FDA-cleared K040187 medicinal leech species.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Source species
- Whitmania pigra
- Discovered
- 2026 · Huang B et al.
Biological Targets
- → fibrinolysis pathways
- → neutrophil elastase
- → elastase
- → Factor Xa
Key Citations
- Huang B et al. (2026), Protein Expr Purif · PMID 42092413
External Resources
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