W. pigra Chromosome-Level Genome (79 Antithrombotic Genes)
Chromosome-level W. pigra genome unexpectedly carries 79 antithrombotic genes — more than the 72 in blood-sucking H. manillensis (Liu 2024).
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Chromosome-level W. pigra genome unexpectedly carries 79 antithrombotic genes — more than the 72 in blood-sucking H. manillensis (Liu 2024).
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
Clinical translation limit
Genome-level antithrombotic gene count does NOT translate to clinical efficacy. Individual gene products require functional characterization. No FDA-approved derivative; W. pigra is a non-hematophagous TCM leech, not the FDA-cleared K040187 medicinal leech.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Source species
- Whitmania pigra
- Discovered
- 2024 · Liu Z et al.
Biological Targets
- → coagulation cascade (predicted across 20 antithrombotic gene families)
Key Citations
- Liu Z et al. (2024), Genes (Basel) · PMID 38397154
External Resources
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