Hirudin-PA
Hirudin variant from Hirudinaria manillensis with distinct kinetics.
Доклинические / механистические данныеLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Hirudin variant from Hirudinaria manillensis with distinct kinetics.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
Hirudin-PA's in vitro thrombin inhibition does not establish clinical efficacy. No FDA-approved derivative based on this variant exists. Mechanism is preclinical/biochemical only.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Molecular weight
- 7,000 Da
- Source species
- Hirudinaria manillensis
Biological Targets
- → thrombin
Key Citations
- Steiner V et al. (1992), Biochemistry
External Resources
Related Anticoagulant Compounds
Hirudin
The most potent natural thrombin inhibitor — and the molecular template for three FDA-approved direct thrombin inhibitor drugs.
Antistasin
Factor Xa inhibitor — prototype molecule that inspired the entire DOAC drug class (rivaroxaban, apixaban).
Ghilanten
Factor Xa inhibitor with anti-metastatic activity in animal cancer models — translational dual-use compound.
Lefaxin
Factor Xa inhibitor with anti-inflammatory properties.