Thrombophilia and Recurrent Pregnancy Loss: The Enigma Continues
Research article published in Medical science monitor : international medical journal of experimental and clinical research (2018)
Abstract
BACKGROUND Thrombophilic gene polymorphism is known to be a risk factor for recurrent pregnancy loss (RPL), but few studies have confirmed a possible role of thrombophilic genes polymorphism in RPL risk. This study was conducted to understand the relationship of the mutations of some thrombophilia-associated gene polymorphism (heterozygous/homozygous) with RPL. We compared patients with 2 abortions to patients with 3 or more abortions among Turkish women. MATERIAL AND METHODS In this study, patients previously diagnosed with habitual abortus at Obstetrics and Gynecology outpatient clinics in Turkey between 2012 and 2016 were included. In their peripheral blood, we detected factor V Leiden H1299R, prothrombin G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G, and PAI-1 4G/4G gene mutations. RESULTS In this study, we have observed statistically meaningful data (P<0.01) related to the relationship between RPL and thrombophilia-associated gene polymorphisms such as heterozygous factor V Leiden H1299R, heterozygous prothrombin G20210A, PAI-1 4G/5G, and PAI-1 4G/4G. CONCLUSIONS We found that diagnosis of thrombophilic genes polymorphism is useful to determine the causes of RPL, recognizing that this multifactorial disease can also be influenced by various acquired factors, including reproduction-associated risk factors and prolonged immobilization.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
BACKGROUND Thrombophilic gene polymorphism is known to be a risk factor for recurrent pregnancy loss (RPL), but few studies have confirmed a possible role of thrombophilic genes polymorphism in RPL risk.
Por qué esto importa para la hirudoterapia
Este estudio de casos y controles en mujeres turcas con abortos habituales examinó si los polimorfismos genéticos asociados a la trombofilia (factor V Leiden H1299R, protrombina G20210A, MTHFR C677T/A1298C, PAI-1 4G/5G y 4G/4G) están vinculados a la pérdida recurrente del embarazo, comparando mujeres con dos frente a tres o más pérdidas; los autores informan asociaciones estadísticamente significativas (P<0.01) para varias variantes, incluyendo el factor V Leiden H1299R y la protrombina G20210A en heterocigosis, y concluyen que el genotipado de la trombofilia es útil en el estudio de la RPL multifactorial. Para la hirudoterapia, esto es contextual en lugar de directo: documenta que un estado hipercoagulable contribuye a un problema clínico real, el cual es la misma biología de la coagulación sobre la que actúa el secretoma de la sanguijuela medicinal (hirudin y otros factores antitrombina), ayudando a contextualizar por qué se estudian los anticoagulantes derivados de sanguijuelas. La advertencia honesta es que este es un estudio observacional de asociación genética en una sola población que no probó ninguna terapia derivada de sanguijuelas ni hirudoterapia, por lo que se refiere únicamente al mecanismo de la enfermedad y no conlleva ninguna implicación para el tratamiento de la pérdida del embarazo con sanguijuelas.
Citación
Thrombophilia and Recurrent Pregnancy Loss: The Enigma Continues.
Barut MU et al. · Medical science monitor : international medical journal of experimental and clinical research, 2018
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 28, 2026 · Última actualización del sitio: June 18, 2026