Management of Neonatal Aortic Thrombosis: Challenges and Outcomes With Systemic and Intra-arterial Thrombolysis.
Case report published in Cureus (2024)
Abstract
Neonatal aortic thrombosis, though rare, is associated with high mortality and is frequently linked to umbilical vessel catheterization, especially in smaller and critically ill infants due to their low levels of natural anticoagulants and increased prothrombotic activity. We report a case of a term neonate with abdominal aortic thrombosis and severe lower limb ischemia, presenting with respiratory distress requiring intubation and subsequent development of thrombosis by day 7. Initial anticoagulation with heparin proved insufficient, necessitating the use of reteplase and intra-arterial thrombolysis, which resulted in clinical improvement despite limited immediate success in Doppler studies. The patient was discharged on low-molecular-weight heparin against medical advice, highlighting the complexities and need for individualized management strategies in neonatal thromboembolism.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Neonatal aortic thrombosis, though rare, is associated with high mortality and is frequently linked to umbilical vessel catheterization, especially in smaller and critically ill infants due to their low levels of natural anticoagulants and increased prothrombotic activity. We report a case of a...
Por qué esto importa para la hirudoterapia
Este reporte de caso describe un neonato a término con trombosis aórtica abdominal e isquemia grave de miembros inferiores, que fue tratado inicialmente con anticoagulación con heparina y, posteriormente, con reteplasa y trombólisis intraarterial tras demostrarse insuficiente la heparina. Es relevante para el dominio de ASH solo en el contexto amplio del manejo anticoagulante y trombolítico de la enfermedad trombótica — el espacio terapéutico en el que también operan los agentes derivados de la hirudina. El resumen no hace referencia alguna a sanguijuelas, hirudoterapia ni hirudina. Su relevancia es indirecta y, como reporte de un caso único, sus hallazgos no son generalizables.
Citación
Management of Neonatal Aortic Thrombosis: Challenges and Outcomes With Systemic and Intra-arterial Thrombolysis.
Reddy et al. · Cureus, 2024
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 28, 2026 · Última actualización del sitio: June 18, 2026