PEROXIDATION OF SALIVA LIPIDS IN PATIENTS WITH POSTCOVID SYNDROME DURING HIRUDOTHERAPY
Research article published in Georgian medical news (2024)
Abstract
INTRODUCTION: With COVID-19, there are isolated reports of a change in the free radical oxidation of blood lipids in the body of patients, however, the state of the half-AOS of saliva remains unexplored. At the same time, the editors of three scientific medical journals have already adopted the author's concept of the name of the disease - "COVID - 19 - POST-COVID SYNDROME". MATERIAL AND METHODS: The saliva of 63 patients with postcovid syndrome (PСS) served as the object of the study. The individual sensitivity of patients to xenobiotics was determined using the isoniazid method. According to the results of sensitivity to xenobiotics, patients were divided into groups: resistant, sensitive and very sensitive groups. RESULTS: Thus, the results of the conducted studies indicate a significant increase in the intensity of free radical lipid oxidation in postcovid syndrome, an increase in the prooxidant index of saliva associated with the sensitivity of the body to xenobiotics. The work carried out made it possible to determine the feasibility of using a medical leech for the rehabilitation of patients with PKS, depending on sensitivity to xenobiotics. The use of hirudotherapy inhibits the intensity of free radical oxidation processes, makes it possible to prevent the development of oxidative stress. CONCLUSION: PKS is characterized by activation of the processes of lipoperoxidation of saliva, an increase in the content of primary, secondary and final POL products in it. The degree of increase in the prooxidant index in the saliva of patients with PKS depends on the sensitivity of the body to xenobiotics.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
With COVID-19, there are isolated reports of a change in the free radical oxidation of blood lipids in the body of patients, however, the state of the half-AOS of saliva remains unexplored.
Por qué esto importa para la hirudoterapia
Este estudio examinó la peroxidación lipídica salival y los marcadores de estrés oxidativo en 63 pacientes con síndrome pos-COVID, clasificados por su sensibilidad a xenobióticos mediante el método de isoniazida, y evaluó si la hirudoterapia influyó en estos marcadores durante la rehabilitación. Es directamente relevante para la hirudoterapia, ya que los autores informan de que la aplicación de sanguijuelas médicas pareció inhibir los procesos de oxidación por radicales libres y podría ayudar a prevenir el estrés oxidativo en pacientes pos-COVID, al mismo tiempo que proponen que el perfil de sensibilidad a xenobióticos podría orientar las decisiones sobre terapia con sanguijuelas. La vinculación conceptual con efectos antioxidantes o mediados por el secretoma salival es plausible, pero aquí no se analiza mecanísticamente. Una salvedad importante es que el resumen aporta datos cuantitativos mínimos sobre los resultados, ningún detalle estadístico y ninguna caracterización de qué componentes derivados de la sanguijuela podrían ser responsables, por lo que las asociaciones reportadas y la conclusión de viabilidad siguen siendo preliminares y requieren mayor validación.
Citación
PEROXIDATION OF SALIVA LIPIDS IN PATIENTS WITH POSTCOVID SYNDROME DURING HIRUDOTHERAPY.
Serikbayeva S et al. · Georgian medical news, 2024
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Añadido a la biblioteca ASH: March 18, 2026 · Última actualización del sitio: June 18, 2026