Conservative management of neonatal cerebral sinovenous thrombosis with coexisting thrombophilia.
Case report published in Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (2018)
Abstract
: Neonatal cerebral sinovenous thrombosis (CSVT) comprises approximately 50% of all pediatric-related CSVT. Although guidelines support anticoagulation in pediatric CSVT, the role of anticoagulation in neonatal CSVT remains controversial. This case report details the course of a neonate diagnosed with extensive CSVT and concurrent bilateral thalamic and intraventricular hemorrhage. Due to existing hemorrhage at the time of diagnosis, anticoagulation therapy was not administered. Despite coexisting protein C and antithrombin deficiency, CSVT resolved spontaneously, and neurodevelopmental follow-up after 13 years suggests a good prognosis. Although our case had a positive outcome, the association between the use of anticoagulation with concurrent hemorrhage and long-term outcome in neonatal CSVT has not been investigated in prospective studies to firmly guide optimum treatment. Current literature and guidelines for the treatment of neonatal CSVT are reviewed in this article. Until robust studies are available, expert opinion recommends anticoagulation in a stable neonate with CSVT.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
: Neonatal cerebral sinovenous thrombosis (CSVT) comprises approximately 50% of all pediatric-related CSVT. Although guidelines support anticoagulation in pediatric CSVT, the role of anticoagulation in neonatal CSVT remains controversial.
Por qué esto importa para la hirudoterapia
Este caso clínico detalla la resolución espontánea de la trombosis cerebral sinovenosa neonatal sin el uso de tratamiento anticoagulante, a pesar de la coexistencia de trombofilia y hemorragia. El estudio aborda el uso controvertido de anticoagulantes sistémicos en neonatos, lo que comparte una conexión temática amplia con los mecanismos anticoagulantes empleados en la hirudoterapia. Resalta las complejidades clínicas del manejo de la coagulación sanguínea en poblaciones de pacientes vulnerables, donde las intervenciones farmacéuticas estándar conllevan riesgos significativos. Sin embargo, el artículo no menciona en absoluto sanguijuelas, hirudoterapia ni sustancias derivadas de sanguijuelas, lo que lo convierte estrictamente en una viñeta clínica sobre el manejo médico conservador.
Citación
Conservative management of neonatal cerebral sinovenous thrombosis with coexisting thrombophilia.
Khatri et al. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2018
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Añadido a la biblioteca ASH: May 28, 2026 · Última actualización del sitio: 18 de junio de 2026