Medicinal Leech Therapy in Urology: A PRISMA-Compliant Systematic Review
Battin AO, Hobeika N, Zdilla MJ (2023) · African Journal of Urology · n=12
Характеристика исследования
- Дизайн
- PRISMA-compliant systematic review of 12 unique medicinal leech therapy cases in urological contexts (MEDLINE/PubMed)
- Размер выборки (n)
- 12
- Вмешательство
- Medicinal leech therapy across 12 urological cases: 4 post-penile replantation, 2 post-scrotal hematoma, 2 post-neonatal bladder exstrophy repair, 1 refractory priapism, 3 penoscrotal edema in hormone refractory prostate carcinoma
- Компаратор
- Within-cohort comparison across diverse urological indications
- Первичная конечная точка
- Clinical improvement and complications across urological leech therapy applications
- Основной результат
- All 12 cases (100%) reported clinical improvement; venous congestion/hematoma cases noted decreased displaced blood volume; priapism case had decreased pain; penoscrotal edema cases had significant swelling reduction; no complications in 9 adult patients; 3 neonatal patients required blood products
- Длительность наблюдения
- Variable across included cases
- PMID
- 41684506
Ключевые выводы
- First PRISMA-compliant urology-specific leech review
- 100% reported clinical improvement across 12 cases
- Diverse indications: replant, hematoma, exstrophy, priapism, edema
- No complications in 9 adult patients
- 3 neonatal cases required blood products (volume-related)
Ограничения
- Small case pool (n=12 unique cases)
- Publication bias toward successful outcomes
- Heterogeneous indications limit cross-comparison
- No control groups available
- PRISMA methodology applied to case-level evidence
Клиническое значение
Battin 2023 establishes leech therapy as a viable urologic adjunct across diverse indications with favorable safety profile in adults. For US clinicians under K040187, this PRISMA review extends device application to refractory priapism, penoscrotal edema, and post-bladder exstrophy congestion contexts beyond the traditional flap-salvage indication. The neonatal blood product requirement highlights age-specific considerations.
Связанные исследования
Successful Microsurgical Replantation of Amputated Penis: A Case Report and Review of Literature
Akhoondinasab MR, Farahmand HR, Zahedi A, Saraee A (2023)
Complete penile amputation during ritual neonatal circumcision and successful replantation using postoperative leech therapy
Banihani OI, Fox JA, Gander BH, Grunwaldt LJ, Cannon GM (2014)
Leeches and Caudal Analgesia After Replantation for Glans Amputation During Neonatal Circumcision
Mousa A, Keefe DT, Wong K, Davidge K, Lorenzo AJ, Dos Santos J (2022)
Penile Replantation: A Review of Microsurgical Techniques, Patient Outcomes, and Solutions to Complex Reconstructive Challenges
Arbel EJ, Reese AD, Richards R, Singh S, O'Shea AW, Hennig F, Abramowitz D (2024)