Effect of Astragali Radix on growth, immunity and related gene expression of Whitmania pigra
Research article published in Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2018)
Abstract
To explore the effect and mechanism of Astragali Radix on growth and immunity of Whitmania pigra, 0, 0.01%, 0.03%, 0.05%, 0.07%, 0.09% of Astragali Radix were added to the daily feeding of Wh. pigra. After 60 days of feeding, the growth performance, activities of digestive enzyme and anti-reverse enzyme, inner quality, the expression levels of GH, IGF-1 and digestive enzyme-related genes were measured. Meanwhile, the effects of heat stress on the living conditions of Wh. pigra were observed and counted, and the expression levels of HSP70 and immune related genes were measured. The results showed that the final weight, weight gain rate, specific growth rate, activities of digestive enzyme and anti-reverse enzyme, the expression levels of GH, IGF-1 and digestive enzyme-related genes in the Astragali Radix group were higher than those in the control group, and with the increase of Astragali Radix concentration, the above-mentioned indexes increased initially and then decreased, and significantly higher in the 0.05% of Astragali Radix group than in the other groups (P<0.05). There was no significant difference in the inner quality of Wh. pigra between the Astragali Radix and control groups. The survival rate of Wh. pigra was negatively correlated with heat stress treatment duration. With the prolongation of heat stress treatment duration, the expression levels of HSP70 and immune related genes were increased first and then decreased, and peaked at 24 h. The survival rate and the expression levels of HSP70 and immune related genes in the Astragali Radix group were higher than those in the control group, and was significantly higher in the 0.05% of Astragali Radix group than in the other groups (P<0.05). In conclusion, Astragali Radix can increase the activities of digestive enzyme and anti-reverse enzyme, the expression levels of related genes, growth performance, and immunity to heat stress of Wh. pigra. It is suggested to add 0.05% of Astragali Radix in the actual production of Wh. pigra to improve the production profit.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
To explore the effect and mechanism of Astragali Radix on growth and immunity of Whitmania pigra, 0, 0.01%, 0.03%, 0.05%, 0.07%, 0.09% of Astragali Radix were added to the daily feeding of Wh.
Por qué esto importa para la hirudoterapia
Este estudio examinó los efectos de la suplementación del alimento con Astragali Radix (un medicamento herbolario chino) sobre el crecimiento, la inmunidad y la expresión de genes relacionados en Whitmania pigra, una especie de sanguijuela, durante 60 días. La concentración del 0,05 % produjo mejoras significativas en el peso final, la tasa de ganancia de peso, la tasa específica de crecimiento, las actividades de enzimas digestivas y anti-inversoras, y la expresión de genes relacionados con el crecimiento (GH, IGF-1). Bajo estrés térmico, Astragali Radix mejoró las tasas de supervivencia y la expresión de HSP70 y de genes inmunitarios, con un pico a las 24 horas. Esto es directamente relevante para el ámbito de la ASH, ya que concierne al cultivo y la salud de las sanguijuelas, aspectos prácticos del mantenimiento de las poblaciones de sanguijuelas. Los hallazgos sugieren que la suplementación con Astragali Radix podría mejorar la productividad del cultivo de sanguijuelas y la resistencia al estrés térmico. Sin embargo, el estudio se centra en la zootecnia de una especie específica de sanguijuela más que en los desenlaces de la hirudoterapia o en las propiedades terapéuticas del secretoma de la sanguijuela.
Citación
Effect of Astragali Radix on growth, immunity and related gene expression of Whitmania pigra
Wu B et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026